Mucoactive Agents Flashcards

1
Q

Mucoactive Agents

Generic Names (4)
Trade Names (2)

A
  1. N-Acetylcysteine (Trade Name: NAC, Mucomyst)
  2. Dornase Alfa (Trade Name: Pulmozyme)
  3. Aqueous Water Saline
  4. Hyperosmolar Saline 3% and 7%
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2
Q

Mucoactive Agents
N-Acetylcysteine (NAC, Mucomyst)

Use
Mode of Action
Hazards (4)

A
  1. Use: None
  2. MOA: Breaks down disulfide bonds
  3. Hazards: Bronchospasms, Rhinorrhea, Stomatitis, Nausea
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3
Q

Mucoactive Agents
Dornase Alfa (Pulmozyme)

Use
Mode of Action
Hazards (6)

A
  1. Use: Used in CF only “orphan drug”
  2. MOA: Reduces the viscosity and adhesivity of DNA polymers in CF
  3. Hazards: Pharyngitis, Laryngitis, Conjunctivitis, Rash, Chest Pains, Voice Alteration
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4
Q

Mucoactive Agents
Aqueous Water Saline

Use
Mode of Action
Hazards (2)

A
  1. Use: Sputum Induction
  2. MOA: Irritant to induce cough. Improves mucociliary transport and lung function. Hydrates airway surface fluids
  3. Hazards: Bronchospasms and Cough
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5
Q

Mucoactive Agents
Hyperosmolar Saline 3% and 7%

Use
Mode of Action
Hazards (2)

A
  1. Use: Airway Clearance for therapy of CF. 3% Infinitive Bronchiolitis
  2. MOA: Irritant to induce cough. Improves mucociliary transport and lung function
  3. Hazards: Bronchospasms and Cough
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