Mucoactive Agents Flashcards
1
Q
Mucoactive Agents
Generic Names (4)
Trade Names (2)
A
- N-Acetylcysteine (Trade Name: NAC, Mucomyst)
- Dornase Alfa (Trade Name: Pulmozyme)
- Aqueous Water Saline
- Hyperosmolar Saline 3% and 7%
2
Q
Mucoactive Agents
N-Acetylcysteine (NAC, Mucomyst)
Use
Mode of Action
Hazards (4)
A
- Use: None
- MOA: Breaks down disulfide bonds
- Hazards: Bronchospasms, Rhinorrhea, Stomatitis, Nausea
3
Q
Mucoactive Agents
Dornase Alfa (Pulmozyme)
Use
Mode of Action
Hazards (6)
A
- Use: Used in CF only “orphan drug”
- MOA: Reduces the viscosity and adhesivity of DNA polymers in CF
- Hazards: Pharyngitis, Laryngitis, Conjunctivitis, Rash, Chest Pains, Voice Alteration
4
Q
Mucoactive Agents
Aqueous Water Saline
Use
Mode of Action
Hazards (2)
A
- Use: Sputum Induction
- MOA: Irritant to induce cough. Improves mucociliary transport and lung function. Hydrates airway surface fluids
- Hazards: Bronchospasms and Cough
5
Q
Mucoactive Agents
Hyperosmolar Saline 3% and 7%
Use
Mode of Action
Hazards (2)
A
- Use: Airway Clearance for therapy of CF. 3% Infinitive Bronchiolitis
- MOA: Irritant to induce cough. Improves mucociliary transport and lung function
- Hazards: Bronchospasms and Cough