MTC Exam 2

Question 1

Ethanol

Answer 1

Comp inhibitor of alcohol dehydrogenase (which converts methanol to formaldehyde)

Question 2

Allopurinol

Answer 2

Non comp inhibitor of xanthine oxidase (in purine synthesis)

Treatment for gout

Question 3

EDTA

Answer 3

Chelates divalent ions at enz active site

Bonds Ca and inhibits activation of proteinase in coagulation

Question 4

Aspirin

Answer 4

Irreversible inhibitor

Acetylates COX1, reduces prostaglandin synthesis

Question 5

Lead

Answer 5

Irreversible inhibitor
Binds aminolevulonic acid dehydrogenase
Inhibiting heme synthesis–>anemia

Question 6

Examples of allosteric inhibition by the end product of the metabolic pathway

Answer 6

Heme inhibits delta-aminolevulinic acid synthase

FA inhibition of acetyl-CoA carboxylase

Question 7

Examples of allosteric regulation of one pathway by product of ANOTHER pathway

Answer 7

Citrate inhibits phosphofructose kinase 1 in glycolysis (dec acetylCoA for lipogenesis)

Citrate activates acetylCoA carboxylase in FA synthesis

Question 8

Examples of allosteric regulation of cells’ energy change

Answer 8

AMP activates glycogen phosphorylase b (glycogen breakdown)

AMP inhibits fatty acid synthesis by inhibition of acetylCoA carboxylase

Question 9

Enz for glycogen breakdown

Answer 9

Glycogen phosphorylase b phosphorylated

Question 10

Enz for triacylglycerol breakdown

Answer 10

HSL phosphorylated and inhibited

Question 11

Enz for glycogen synthesis

Answer 11

Glycogen synthase is phosphorylated

Question 12

Enz for FA synthesis

Answer 12

AcetylCoA carboxylase is phosphorylated

Question 13

Vioxx

Answer 13

Comp inhibitor of prostaglandin synthesis cyclooxygenase 2

Dec inflammation

Question 14

Enz that uses thiamin as activation transfer coenzyme

Answer 14

Alpha ketoglutarate dehydrogenase complex

Inhibition leads to accumulation of alpha ketoacids in heart–>cardiomyopathy in beriberi

Question 15

Lipoic acid is coenzyme for

Answer 15

Pyruvate

Alpha ketoglutarate dehydrogenase

Question 16

BH4 is cofactor for

Answer 16

Phenylalanine hydroxylase

Question 17

Metal ions for cytochrome oxidase in ETC

Answer 17

Fe3+

Cu2+

Question 18

Metal ions used for glutathione Peroxidase (defense against free radicals)

Answer 18

Se2+

Question 19

Metal ions used hexokinase

Answer 19

Mg2+

Question 20

AZT

Answer 20

AIDs treatment
Mito myopathy
RRF accumulation
Inhibits mtDNA pol

Question 21

Atractylate

Answer 21

ATP-ADP Translocase inhibitor
Inhibits ADP binding to Translocase
Found in Mediterranean plants

Question 22

Bongkrekate

Answer 22

Inhibits ATP binding to Translocase in matrix
Very toxic
Found in southeast Asian plants

Question 23

Alpha 1 globulins

Answer 23

Alpha 1 antitrypsin

Alpha 1 acid glycoprotein

Question 24

Alpha 2 globulins

Answer 24

Haptoglobulins
Alpha 2 macroglobulin
Ceruloplasm

Question 25

Beta globulin

Answer 25

Transferrin
LDL
Complement C3

Question 26

Gamma globulins

Answer 26

Ig’s

Question 27

Transthyretin

Answer 27

Retinol transport

Binds T4

Question 28

Albumin

Answer 28

Colloid oncotic pressure

Binding protein

Question 29

Retinol binding protein

Answer 29

Retinol transport

Question 30

Alpha 1 antiprotease

Answer 30

Protease inhibitor

Question 31

Thyroxine binding globulin

Answer 31

Binds T3 and T4

Question 32

Transcortin

Answer 32

Binds glucocorticoids

Question 33

Alpha fetoprotein

Answer 33

Elevated in adults with hepatoma

Question 34

Ceruloplasm

Answer 34

Contains copper

Question 35

Alpha 2 macroglobulin

Answer 35

Protease inhibitor

Question 36

Haptoglobulin

Answer 36

Binds hemoglobin

Question 37

Transferrin

Answer 37

Binds Fe

Question 38

Hemopexin

Answer 38

Binds heme

Question 39

Fibrinogen

Answer 39

Clot formation

Question 40

C reactive protein

Answer 40

Acute phase reactant

Question 41

Immunoglobulins

Answer 41

Very heterogenous