MTB - Obstetrics Flashcards
3 things that suggest pregnancy?
amenorrhea
enlargement of uterus
+ urine B-hcg
when can you see a gestational sac?
4-5 weeks by transvaginal USG
level of B-HCG when you can see a gestational sac
1500 mIU/ml
fetal heart movement first seen on USG
5-6 weeks
fetal heart tones first heard by doppler
8-10 weeks
CCS TIP - when you have a newly diagnosed pregnant patient, what should you always order?
pregnancy counselling
ORDER icon: “counsel patient, pregnancy”
finding of anemia - first tri labs
Hb < 10 g/dL
most reliable indicator in pregnancy = MCV
MCC of anemia in pregnancy
iron deficiency
pregnant pt with LOW Hb and LOW MCV
give iron
- if anemia does not improve, test for thalassemia
pregnant pt with LOW Hb, high MCV, high RDW
give folate
when should you give RhoGAM to pregnant pts?
to RH negative mothers:
- at 28 weeks after first rescreening
- after any procedure (CVS, amniocentesis)
- after delivery
Tx of asymptomatic bacteriuria in pregnancy
Nitrofurantoin - if before 30 weeks
Cephalosporins
Amoxicillin
a pregnant pt is rubella IgG ab negative - when should you vaccinate her?
after delivery
- do NOT give rubella vaccine during pregnancy
pregnant pt has positive HbsAg - what test should you order next?
HBeAg
- signifies highly infectious state
tx. of syphillis in pregnancy
IM penicillin
- if allergic, desensitize and then tx with penicillin
tx. pf Chlamydia/gonorrhea in pregnancy
PO azithromycin + IM ceftriaxone
alternative: PO amoxicillin
tx. of Bacterial Vaginitis in pregnancy
PO metronidazole or clindamycin PO
tx. of trichomonas vaginalis in pregnancy
PO metronidazole
MCC of abnormal serum MS-AFP
gestational dating error
first test to order if abnormal serum MS-AFP
USG
inhibin A
made by placenta during pregnancy, remains constant during 15-18th week
- elevated in DOWNs
what is the triple marker screen and when should you order it?
between 15-20 weeks gestation
MS-AFP
B-hcg
Estriol
causes of increased MS-AFP
neural tube defects ventral wall defects twin pregnancy placental bleeding renal disease saccrococcygeal teratoma
causes of decreased MS-AFP
trisomy 21
trisomy 18
triple marker screen - Trisomy 21
low MS-AFP
low Estriol
high B-HCG
triple marker screen - Trisomy 18
all three low
dates are normal, MS-AFP is high - what do you order next?
amniocentesis for:
- AF-AFP level
- acetylcholinesterase activity
dates are normal, MS-AFP is low - what do you order next?
amniocentesis for:
- karyotyping
elevated levels of amniotic fluid - acetylcholinesterase activity are specific for…
open NTD
screen for diabetes in pregnancy
24-28 weeks: 1 hr - 50 g OGTT abnormal result (i.e. > 140 mg/dL): f/u with 3 hr - 100 g OGTT
RhoGAM is not indicated in…
RH neg. women who have developed anti-D ab’s
RH pos. women
GBS screening in pregnancy
at 35-37 weeks (Vaginal and rectal culture)
tx. of positive GBS result
intrapartum antibiotics
- IV penicillin G
- if allergic: IV clindamycin or erythromycin
abnormal 3 hr- OGTT results
1 hr = > 180 mg/dL
2 hr = > 155 mg/dL
3 hr = > 140 mg/dL
safe to use in pregnancy - anti-emetics
doxylamine metoclopramide ondansetron promethazine pyridoxine (vit B6)
painful late vaginal bleeding
abruptio placenta OR uterine rupture
painless late vaginal bleeding
placenta previa OR vasa previa
signs of fetal compromise on fetal monitoring (esp. with bleeding)
late decelerations and/or bradycardia
CCS - initial steps in management of LATE PREGNANCY BLEEDING
- patient’s vitals
- place external fetal monitor
- start IVF with normal saline
CCS - what labs should you order in LATE PREGNANCY BLEEDING
CBC
DIC workup - platelets, PT, PTT, fibrinogen, D-dimer
type and cross-match
obstetric ultrasound - r/o previa
CCS - further steps in management of late pregnancy bleeding
- if large volume blood loss = transfusion
- place foley catheter, measure UO
- perform vag. exam to r/o lacerations
- schedule delivery if fetus is in jeopardy or GA > 36 weeks
a patient presents with late pregnancy bleeding - what should you NEVER do?
never place a speculum or perform digital exam BEFORE getting an USG to r/o placenta previa
sudden onset vaginal bleeding in a pregnant patient with severe, constant pelvic pain - dx?
abruptio placenta
RF - abruptio placenta
HTN
trauma - MVA
tobacco, cocaine use
uterine distension
suddent onset painless vaginal bleeding that may occur at rest or with minimal activity; the bleeding usually stops on its own - dx.
placenta previa
- low implantation of placenta on or near the cervical os in lower uterine segment
RF for placenta previa
prior C/S
grand multiparities
multigravida
prior hx. of previa
placenta accreta
does not penetrate entire thickness of enometrium
placenta increta
extends further into the myometrium
placenta percreta
placenta penetrates the entire myometrium and uterine serosa
patient comes in with rupture of membranes, painless vaginal bleeding and fetal bradycardia - dx?
vasa previa
vasa previa
velamentous cord insertion results in umbilical cord vessels crossing the placental membranes over the cervix; if membranes rupture, fetal vessels are torn leading to blood loss from fetal circulation
first step in management in vasa previa
emergency c-section!
pregnant pt presents with sudden onset abdominal pain and vaginal bleeding; she had a prior C/S and currently, her baby has bradycardia and its head is recessed; there are no uterine contractions
uterine rupture
GBS meningitis
hospital acquired infection - occurs after first week of life; unrelated to vertical transmission
tx. of positive GBS screen at 34-38 weeks
IV intrapartum penicillin
allergic? IV cefazolin, clindamycin or erythromycin
who should receive GBS prophylaxis?
- positive culture at anytime in pregnancy
- high risk factors:
- preterm
- ROM > 18 hours
- maternal fever
- previous baby with GBS sepsis
who should NOT get GBS prophylaxis?
- planned C/S w/o rupture of membranes
2. culture positive previous pregnancy, but culture negative in current pregnancy
classic triad of congenital toxoplasmosis
chorioretinitis
intracranial calcifications
hydrocephalus
tx. if mother has primary toxoplasma infection
spiramycin
- given to prevent vertical transmission
IgM and IgG toxoplasma are positive - what should you check?
IgG avidity
high = r/o gestational infection
low = recent exposure
Tx. of serologically confirmed fetal/neonatal toxoplasma infection
pyrimethamine and sulfadiazine
at what time is the fetus at highest risk if mother has primary varicella infection?
between 5 days antepartum and 2 days postpartum
neonatal varicella infection
zigzag skin lesions limb hypoplasia microcephaly microphthalmia chorioretinitis cataracts
post exposure prophylaxis of varicella infection in pregnancy
VariZAG (ab) or VZIG w/in 10 days of exposure
- attentuates the clinical effects of the virus
Tx. maternal varicella
VariZAG to mother and neonate
Tx. congenital varicella
VariZAG and IV acyclovir to neonate
congenital rubella syndrome
congenital deafness heart defects - PDA cataracts hepatosplenomegaly thrombocytopenia blueberry muffin rash
MC congenital viral syndrome
congenital CMV
MCC of sensorineural deafness in children
CMV
Manifestations of congenital CMV infection
IUGR, prematurity microcephaly jaundice petechiae hepatosplenomegaly periventricular calcifications chorioretinitis pneumonitis
Tx. congenital CMV infection
antiviral therapy - ganciclovir
- prevents viral shedding and prevents hearing loss but does not cure infection
precautions for active HSV infection in woman in labour
- scheduled C/S
2. do not use fetal scalp electrodes for monitoring (increased risk of HSV transmission)
Tx. of primary HSV infection in pregnancy
acyclovir
drug therapy in HIV positive pregnant woman
- triple therapy for mom
- IV intrapartum ZDV
- combination ZDV-based ART for 6 weeks after delivery for baby
what other prophylactic treatment should an infant born to an HIV positive mother be given?
TMP-SMX prophylaxis of pneumocystic pneumoniae (continue for 6 weeks after ART therapy has completed)
when should an HIV positive pregnant woman have a C-section?
at < 38 weeks unless her viral load is < 1000 copies/ml
CF: early acquired congenital syphillis
non-immune hydrops fetalis
maculopapular/vesicular peripheral rash
anemia, thrombocytopenia, hepatosplenomegaly
large, edematous placenta
late acquired congenital syphillis
diagnosed after age 2
- Hutchinson teeth
- mulberry molars
- saber shins
- deafness (CN 8 palsy)
case describes a woman with painless genital ulcer - what test should you order?
darkfield microscopy
- VDRL or RPR will be falsely negative
which maternal infections are contra-indications to breast feeding?
HIV
active tuberculosis
HTLV-1
HSV - if there is a lesion on breast
which disease present in infant is a C/I to breast feeding?
galactosemia
if mom is found to be HBsAb negative….
give active immunization in pregnancy
post exposure prophylaxis of HBV
HBIG - passive immunization
chronic gestational HTN
history of elevated BP before pregnancy or diagnosis before 20 weeks gestation
gestational HTN
BP develops > 20 weeks gestation and returns to normal baseline by 6 weeks post partum
- MC in multifetal pregnancy
mild pre-eclampsia
- sustained BP > 140/90
2. proteinuria of 1-2+ (dipstick) or > 300 mg/24 hr
severe pre-eclampsia
- sustained BP > 160/110
- proteinuria of 3-4+ (dipstick) and > 5 g/24 hr
- presence of warning signs
warning signs in pre-eclampsia
headache
epigastric pain
changes in vision
pulmonary edema
RF: severe pre-eclampsia
primiparas - most at risk multiple gestation hydatidiform mole diabetes mellitus age extremes chronic HTN chronic renal disease
chronic HTN with superimposed pre-eclampsia
chronic HTN with increasingly severe HTN, proteinuria and/or warning signs
eclampsia
unexplained grand mal seizures in a hypertensive and/or proteinuric pregnant patient in last half of pregnancy
HELLP syndrome
hemolysis
elevated liver enzymes
low platelets
what tests should you order in suspected Eclampsia
CBC, Chem 12, coagulation, LFTs, urinalysis with urinary protein, DIC panel