MTB (3) 1 Flashcards
What are cervical cultures in PID
Negative
WHat does sonogram show for PID
BL cystic pelvic masses
Management of Chronic PID
Lysis of tubal adhesions
Presentation of Tuboovarian Abscess (TOA)
Ill-appearing woman
Severe, lower abdominal pelvic pain
Back pain, Rectal pain
Systemic Si’s - N/V, fever, tachy
Labs for Tuboovarian Abscess
WBC and ESR = high
Tuboovarian Abscess sonogram
Unilateral pelvic mass
Pus on culdocentesis
What is a culdocentesis
Fluid extraction from rectouterine pouch posterior to vagina via needle
Management for Tuboovarian Abscess
- Admit to hospital
- IV Clindamycin and IV genta micin
- If no response or rupture -> Exploratory lapartomy
Primary Dysmenorrhea Presentation
Recurrent, crampy, lower abdominal pain
N/V/D during menstruation
Sx’s begin 2.5 yrs after menstruation
Pathophysiology of Primary Dysmenorrhea
Excessive endometrial PGF2 - causes uterine CTX adn acts on GI smooth muscle
Management for Primary Dysmenorrhea
NSAIDS
OCPs (combination)
MCC of Secondary Dysmenorrhea
Endometriosis
Adenomyosis
Leiomyoma
What is primary amenorrhea
Absence of menses age 14 w/out secondary sexual development
Or age 16 WITH secondary sexual development
WU for primary amenorrhea
- PE and US
- Breasts present or absent? Estrogen production
- Uterus present or absent? - Karyotype, testosterone, FSH
What is mullerian agenesis
Normal female secondary sexual traits
Normal estrogen/testosterone
Absence of Mullerian duct derivatives -fallopian tubes, uterus, cervix, upper vagina
Management of mullerian agenesis
Reconstructive surgery to elongate vagina for sexual intercourse
WU for primary amenorrhea w breasts absent
FSH and Karyotype
Androgen Insensitivity Presentation
US
No pubic or axillary hair
Male genotype
US - testes produce normal estrogen (F) and testosterone (M) levels
Management for Androgen Insensitivity
Remove testes before 20
Risk of testicular cancer
Estrogen replacement
Turner syndrome Karyotype
Presentation
Labs
45, XO
Absent secondary sexual traits
Streak gonads
High FSH
Management of Turner’s
Estrogen and progesterone replacement for development of secondary sexual characteristics
Hypothalamic-Pituitary Failure
Presentation
Labs
No sexual characteristics
Normal uterus on US
FSH LOW
Kallman syndrome
Hypothalamic - pituitary failure + Anosmia
Hypothalamus not producing GnRH
Tx for Hypothalamic-Pituitary Failure
Estrogen and progesterone replacement for development of secondary sexual characteristics
What is secondary amenorrhea
Regular menses replaced with absence of menses - 3 months
OR
Irregular menses replaced by absence of menses - 6 months
WU of secondary amenorrhea
- B-hCG
- TSH to R/O hypothyroid (Hi TRH = Hi PRL)
- PRL - meds, AP’s = anti-Da = Hi PRL
- CT/MRI r/o tumor - Progesterone Challenge
- Estrogen Challenge
Pituitary tumor
CT/MRI
- tumor < 1cm = Bromocriptine
- Tumor > 1cm = Surgery
What does withdrawl bleeding in progesterone challenge test mean?
Anovulation
What cancer are PCOS pts at risk for and why?
Endometrial cancer
Unopposed estrogen b/c no corpus luteum to make progesterone
Testosterone level in PCOS
Increased total and free = mildly elevated
- Increased LH - increased theca cell production of androgens - hepatic production of SHBG suppressed =increased testosterone
Tx for PCOS
- OCPs - irregular bleeding, hirsutism
- Spironolactone - suppresses hair follicles
- Clomiphene citrate - infertility
- Metformin- ovulation/insulin resistance
Rapid onset hirsutism + virilization + NO FHX
Adrenal/ovarian tumor
How to differentiate adrenal and ovarian tumor
Adrenal = High DHEAS Ovarian = High testoserone
Next step in management adrenal/ovarian tumor after labs
US - adnexal mass
CT - adrenal mass
CAH - 21-OH deficiency Presentation
Gradual onset hirsutism + NO Virilization 2nd or 3rd decade Menstrual irregularities Anovulation Precocious puberty + short stature
Labs in CAH - 21-OH deficiency
TX
Elevated serum 17-hydroxyprogesterone
Corticosteroid replacement
What is the T score in osteoporosis
> -2.5
MOA of bisphosphonates
Inhibit osteoclastic activity
Benefits of HRT
Decrease osteoporotic Fx
Decrease rate of colorectal cancer
Risks of HRT
Increased risk of
DVT
MI
Breast cancer if tx > 4yrs
Next step if pt unable to conceive, semen analysis is low
Repeat in 4-6 wks
Infertility WU
- Semen analysis
- Anovulation WU
- Fallopian tube abnormalities