MTB Flashcards
Rett disorder Presentation
Progressive encephalopathy Microcephalopathy Hand wringing Loss of speech Ataxia Psychomotor retardation
Child Disintegrative disorder Presentation
Normal development first 2 yrs
Regression after 2
Repetitive/stereotyped movements
Oppositional defiant disorder Presentation and management
Usually by 8 yoa
Argumentative, loss of temper, blame others
Authority figure issues
Teach parents coping skills
Diff bt Antisocial v Conduct Disorder
Antisocial > 18 yoa
Conduct < 18 yoa
Assn’s w Conduct Disorder
Parents w Antisocial
Parents w Alcohol dependence
Diff bt oppositional defiant disorder v Conduct Disorder
ODD - do not break rules, commit crimes
Conduct disorder - do break rules/commit crimes
How do tics present
Preceded by irresistible urges, followed by relief
Exacerbated by stress and fatigue
Comorbidities w Tourette
OCD
ADHD
Tourette presentation
Multiple tics
Last > 1 year
Before Age 18
TX for Tourette
Dopamine Antagonists APs = Risperidone (2nd G AP) FDA approved are 1st G AP, used less b/c of AEs - Haloperidol - Pimozide
How long must major depression be present for Dx
2 weeks
What is MDD
Anhedonia
+
4 others = SIGECAPS
weight, sleep, psychomotor, fatigue, concentration, worthlessness, death thoughts
MC medical cause of depression
Hypothyroidism
MC Neuro Assn w depression
PD
Management of Pt on SSRI w improvement but not full response
Increase dose
Management of Pt on SSRI w single episode of depresssion
Continue SSRI for 6 months and follow pt
Management of pt w depression + neuropathic pain
Desvenlafaxine
SNRI
Management of pt w depression + fearful of weight gain or sexual AEs
Bupropion
Bipolar Disorder Presentation
Mood disorder - typically starts w depression
Pt has manic sx’s that last at least ONE WEEK + cause significant distress in level of functioning
Manic sx’s in Bipolar
DIG FAST
DX for Bipolar
R/O drugs - cocaine, amphetamine
Difference bt mania and hypomania
Mania - last more than 1 week -affect functioning - severe enough for hospitalization - psychotic features Hypomania - less than 1 week - do not severely affect functioning
Is depression required for Bipolar I DX?
No. Mania alone is enough for Dx.
What is required for Bipolar II DX?
Hypomania
Depression - at least 1 MDD Sx required
TX for Bipolar - Acute mania
Lithium Valproic acid Atypical APs = OAR - Olanzapine - Aripripazole - Risperidone
TX for Bipolar Depression
Lithium
Lamotrigine
Steps in management of Acute Mania
- Hospitalize
- Mood stabilizers
- APs. DOC = Risperidone
- IM depot phenothiazine - noncompliant, severely manic
- Antidepressants IF hx of recurrent episodes depression
Presentation of Pseudodemntia
Elderly
Severe depression + memory impairment
Aware/concerned of cognitive decline
TX for Pseudodemntia
SSRI
- reversible with AD
Dysthymia Presentation
Depressed mood most of the day, continuous
Sx’s for more than 2 YEARS
TX for Dysthymia
ADs + Psychotherapy
Cyclothymia Presentation
Hypomanic episodes + Mild depression
Sx’s for more than 2 YEARS
TX for Cyclothymia
Pscyhotherapy +
- Lithium
- Valproic Acid
- Carbamezapine
Atypical Depression Presentation
Reverse vegetative sx’s
- increased sleep, weight, appetite
Mood worse in evening
Pts feel “heavy”
TX for Atypical Depression
SSRIs or MAOIs
Seasonal Affective Disorder
Wt gain, increased sleep, lethargy in winter
TX: Phototherapy
How long do grief sx’s last?
Up to 1 year, typically less 6 months
TX for grief
Supportive therapy
Medical tx = wrong
ADs safe in pregnancy
SSRIs - except Paroxetine (Paxil)
TCAs
SSRIs first line TX for
MDD Bipolar Anxiety disorders Panic disorder, OCD, Social phobia, GAD Bulimia nervosa
AD for enuresis
Imipramine
AD for severe insomnia
Trazodone
Postpartum blues Presentation Onset Sx's Mother's feelings TX
Immediately after birth -> 2 weeks
Sadness, mood, lability, tearfulness
No negative feelings twd baby
Supportive
Postpartum Depression Presentation Onset Sx's Mother's feelings TX
W/in 1-3 months after birth
Depressed mood, Wt/sleep changes, excess anxiety
May have negative feelings twd baby
ADs
Postpartum Psychosis Presentation Onset Sx's Mother's feelings TX
W/in 2-3 weeks after birth Depression, delusions, thoughts of harm May have thoughts of harming baby APs, Lithium, maybe ADs Step 3 says avoid meds if breastfeeding, choose ECT
AE of ECT
Transient memory loss
Induced transient intracracranial pressures
AE’s of TCAs
HypoTN Dry mouth Constipation Arrhythmias - QT prolongation Sexual AE's Weight GAIN GI disturbances Insomnia
AE’s of MAOI’s
HTN w tyramine
AE’s of SSRI’s
HA
Wt changes
Sexual AE’s
GI disturbances
AE’s of Lithium
Acne Weight gain Tremors GI disturbances Nephrotoxic Teratogenic Leukocytosis DI - polyuria, Hypothyroidism SEVERE = confusion, ataxia, lethargy, abnormal reflexes
AE’s of Valproic Acid
Weight gain Tremors GI disturbances Alopecia Teratogenic Hepatotoxic Toxicity - Hyponatremia, coma, death
Presentation of Serotonin Syndrome
Cognitive: confusion, agitation, hallucinations, hypomania
Autonomic: sweating, tachycardia, hyperthermia, N/D, shivering
Somatic: tremors, myoclonus
Management of Serotonin Syndrome
- Stop SSRI
- Tx fever, diarrhea, HTN
- Cyproheptadine = serotonin antagonist