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Rheumatology > MTB > Flashcards

MTB Flashcards

1
Q

Rheumatoid Arthritis Marker that has high specificity and good for early diagnosis

A

Anti-CCP

Anticitrulline-containing protein IgM Abs

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2
Q

MTX

A

First line DMARD RA Tx; slows dz progression

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3
Q

Infliximab

A

RA tx: First line DMARD NOT responding to MTX

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4
Q

Rituximab

A

Resistant cases of RA

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5
Q

RA pt with occipital HAs and UE tingling and numbness

A

Atlantoaxial subluxation - excessive movement at jnc of C1 (atlas) and C2 (axis) and pannus formation at synovial joints

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6
Q

RA with swollen painful calf

A

Baker cyst rupture, mimicking DVT

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7
Q

Hydroxychloroquine

A

DMARD for Mild Dz monotherapy

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8
Q

RA Presentation

A

BL, symmetric joints involved - PIP and MCP (no DIP) - hands, wrists, knees, ankles

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9
Q

Felty sydrome

A

RA + splenomegaly + neutropenia

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10
Q

Caplan syndrome

A

RA and Pneumoconiosis, lung nodules

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11
Q

MCC death in RA

A

Coronary Artery Dz

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12
Q

Sulfasalazine

A

DMARD added to MTX if anti-TNF agents ineffective

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13
Q

Symptom control for pain in RA

A

NSAIDS: best initial therapy for pain control

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14
Q

Gold Salts

A

RA tx

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15
Q

Renal Dz in SLE

A

MC Glomerulonephritis - Membranous seen in severe dz

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16
Q

SLE Ocular findings

A

Photophobia, photosensitivity, blindness, retinal lesions -cotton wool spots = fluffy white patches ass’d w/ischemia causing nerve fiber damage.

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17
Q

Cotton Wool spots

A

fluffy white patches ass’d w/ischemia causing nerve fiber damage.

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18
Q

Complement levels affected in SLE

A

C3 and C4 Decreased = correlate with dz activity

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19
Q

SLE Pregnancy Screen

A

Screen all for SSA/anti-Ro abs - cross placenta, passively transferred to fetus - cause neonatal lupus and heart block

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20
Q

Markers in SLE flare up

A

Low complement levels

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21
Q

SLE flare up tx

A

Steroids

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22
Q

Death in SLE in young patients

A

Young pts: Infxn

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23
Q

SLE Tx

A 
Sx control
Avoid sunlight
NSAIDs
Hydroxychloroquine
Corticosteroids
Anticoagulate PRN
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24
Q

Causes of Drug induced Lupus

A

Hydralazine, INH, Phenytoin, Procainamide, Quinidine

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25
Q

Antiphospholipid syndrome

A

Majority NOT ass’d with SLE

26
Q

Abs to Scl-70 are what?

A

Anti-DNA topoisomerase 1 abs

27
Q

Best initial test for Antiphospholipid syndrome

A

Mixing study: mix patient’s plasma w/ equal amt normal plasma.

28
Q

Most specific test for Lupus anticoagulant

A

Russel viper venom test (RVVT) - prolonged w/ APL abs

29
Q

When do we Investigate for anticardiolipin ab for abortion and TX

A

Two or more FIRST trimester events

30
Q

Symmetric and Polyarticular Arthritis

A

RA

31
Q

Dz’s ass’d with Primary biliary cirrhosis

A

Sjogrens

32
Q

Most dangerous complication of Sjogrens

A

Lymphoma (since lymphocytic dz)

33
Q

Testing for Sjogrens

A

Best initial: Schirmer’s test = decreased tear production

34
Q

Tx for Sjogrens

A

Best initial: water mouth, also flouride, artificial tears

35
Q

Test for Ankylosing spondylitis

A

Best initial: xray SI joint

36
Q

Treatment Ankylosing spondylitis

A

Exercise program and NSAIDS

37
Q

Osteoarthritis (DJD) affects what?

A

Articular cartilage - destruction and secondary remodeling and bone hypertrophy

38
Q

OA Risk factors

A

age, female, genetic, trauma, repetitive use, obesity

39
Q

OA affects what joints?

A

Weight bearing joints: Knee - MC joint involved; Base of thumb - 2nd MC; DIP and PIP involved

40
Q

OA Tx

A
  1. PT and weight loss
  2. NSAIDs
  3. Scheduled Acetaminophen
41
Q

OA Diagnosis

A

Most accurate: radiography: X-ray shows joint space narrowing, ostephytes, dense subchondral bone, bone cysts

42
Q

Acute Gout Tx

A
  1. NSAIDs
43
Q

Chronic Gout non medical TX

A
  1. Wt loss, low purine diet, limit alcohol
44
Q

Allopurinol during an acute attack

A

Do NOT start

45
Q

Pseudogout causes

A 
4 H's: 
Hyperparathyroidism
Hemochromatosis
Hypophosphatemia
Hypomagnesemia
46
Q

Wegeners Best initial test

A

C-ANCA = anti-proteinase-3 abs

47
Q

Polyarteritis Nodosa organs involved

A

NO lung involvement; Skin, Kidneys, nerves, GI

48
Q

Churg-Strauss
Systems involved
Abs involved?

A

Pulmonary and renal involvement, P-ANCA

49
Q

Cryoglobinemia

A

HCV - Chronic

50
Q

Polymyalgia Rheumatica

A

Pain and stiffness in shoulder and pelvic girdle muscles

51
Q

Glomerular dz ass’d with cryoglobinemia

A

Membrano proliferative

52
Q

Cold Agglutinin Ass’d with?

A

EBV, Mycoplasma, lymphoma

53
Q

Septic Arthritis Treatment

A

Ceftriaxone and Vancomycin

54
Q

Polymyositis and dermatomyositis

A

Proximal muscle weakness - difficulty getting up from seated position or walking up stairs

55
Q

Dermatomyositis

A

Malar involvement, shawl sign, heliotrope rash (eyelids), Gottron papules (PIP and MCP - scaly patches)

56
Q

Henoch Schonlein Purpura Renal involvement

A

IgA mediated - deposition in mesangium

57
Q

Behcet Syndrome
Population?
Presentation?
TX?

A 
Asian/ME
Recurrent painful oral and genital ulcers
Arthritis
Conjunctivitis, uveitis
Tx: Supportive, steroids during flares
58
Q

Fibromyalgia

A

Trigger points: Trapezius, medial fat pads - knees, lateral epi elbow, medial epi knee

59
Q

Spinal cord compression causes

A

Malignancy/Infxn

60
Q

Disc Herniation aka?

A

Sciatica

61
Q

Lumbar Spinal Stenosis

A

Pain worse with Extension - leaning back - worse when walking downhill, better with Flexion - when sitting, leaning foward

62
Q

Dupuytren Contracture

A

Hyperplasia =palmar fascia -> nodule formation, contracture of 4th and 5th fingers

Rheumatology (1 decks)

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