MTB 1 Flashcards
Relationship bt Digoxin and Potassium
Both compete for biding at same site on Na/K ATPase
Hypokalemia predisposes to digoxin toxicity
Presentation of Digoxin Toxicity
GI probs: N/V/Abdominal Pain
Hyperkalemia
Confusion
Visual cahnges - yellow halos around objects
Arrhythmias - AV block, A tach, Bradycardia
Most accurate test for Digoxin Toxicity
Digoxin level
Best initial test for Digoxin Toxicity
K level
EKG
EKG of Digoxin Toxicity
Downsloping of ST segment in ALL leads
Atrial Tachycardia w variable AV block = MC
TX for Digoxin Toxicity
Control K+
Digoxin-specific Abs
-Esp if CNS and cardiac involvement
Presentation of Lead Poisoning
Abdominal pain = lead colic ATN Anemia - Sideroblastic Peripheral neuropathy - wrist drop CNS changes - memory loss and confusion
Most Accurate test for Lead poisoning
Lead Level
Best initial diagnostic test in lead poisoning
Increased level of free erythrocyte protoporphyrin
Most accurate test for Sideroblastic anemia
Prussian blue stain
TX for Lead Poisoning
Succimer - oral
Dimercaprol - parenteral
EDTA - parenteral
Presentation of Mercury Poisoning
Neuro problems - nervous, jittery, twitchy, hallucinations
Inhaled - Interstitial fibrosis
TX for Mercury Poisoning
Chelating agents
- Dimercaprol
- Succimer
Methanol and Ethylene glycol poisoning Presentation
Intoxication
Metabolic Acidosis with Increased AG
Cause of Methanol Toxicity
Wood Alcohol
Cleaning solutions
Paint thinner
Cause of Ethylene Glycol Toxicity
Antifreeze
Diff b/t Methanol and Ethylene glycol poisoning
Methanol - ocular toxicity
EG - Renal toxicity
Toxic metabolites of Methanol and Ethylene glycol poisoning
Methanol - Formic Acid/formaldehyde
EG - Oxalic acid/oxalate
How to calculate Osmolar GAp
Serum Osmolality = 2 x Sodium + BUN/2.8 + glucose/18
Best initial TX for toxicity for Methanol and Ethylene glycol poisoning
Fomepizole - inhibits alcohol DH