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MTB 1 Flashcards

1
Q

Worst prognostic factor for Melanoma

A

Growing lesions

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2
Q

Most important prognostic factor

A

Tumor thickness

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3
Q

Best diagnostic test for melanoma

A

Full thickness BX

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4
Q

TX for melanoma

A

Surgical removal

IFN in widespread dz

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5
Q

Where does melanoma mets to

A

Brain

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6
Q

What determines the size of margin excised in melanoma

A

Tumor thickness

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7
Q

Risk factors for SQCC in derm

A

Sunlight
Organ transplant
Long term use of immunosuppressive drugs

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8
Q

Ulcer on lips that does not heal

A

SQCC

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9
Q

Presentation of Basal Cell Ca

A

Waxy lesion

Shiny like a pearl

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10
Q

TX for Basal CC

A

Shave BX

Mohs - esp eyelids, ear

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11
Q

Which virus ass’d with Kaposi

A

HHV-8

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12
Q

Presentation of Kaposi

A 
Older men
Mediterranean
Reddish/purple
GI tract, Lung 
Predominantly AIDS < 100 CD4
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13
Q

Is Kaposi Sarcoma treated w surgical removal

A

No

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14
Q

Tx for Kaposi Sarcoma

A
  1. AIDS - antiretrovirals
  2. Intralesional Vincristine or IFN
  3. Liposomal doxorubicin
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15
Q

Actinic Keratosis - risk of cancer?

A

Yes - premalignant

Small risk for SQCC

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16
Q

TX for actinic keratosis

A 
Must remove w: 
Curettage
Cryotherapy 
Laser 
Topical 5-FU 
Imiquimod
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17
Q

Imiquimod Tx for?

A
  1. Actinic keratosis
  2. Molluscum contagiosum
  3. Condyloma acuminatum
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18
Q

Seborrheic Keratoses Presentation

A

Elderly
Hyperpigmented
Stuck on appearance

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19
Q

Malignant potential for Seborrheic Keratoses?

TX?

A

No.

Tx: removal w cryotherapy, surgery, laser

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20
Q

Atopic Dermatitis Pathophys

Presentation

A

Mast cell overactivity
Asthma, allergic rhinitis, Fam Hx, onset before 5
Pruritis, scratching, scaly rough areas

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21
Q

TX for Atopic Dermatitis

A
  1. Topical Corticosteroids
  2. Tacrolimus and Pimecrolimus
  3. Antihistamines
    Severe = doxepine
  4. ABx - Cephalexin, mupirocin, repatamulim w impetigo
  5. UV light
22
Q

Drugs ass’d with lymphoma

A

Tacrolimus and Pimecrolimus

23
Q

Are psoriasis plaques itchy?

A

Not most of the time

24
Q

Psych issue ass’d with psoriasis

A

Depression

25
TX for psoriasis - Local Disease
1. Topical hi potency steroids 2. Vit A and Vit D ointment (calcipotriene) 3. Coal Tar 4. Tacrolimus and Pimecrolimus on delicate areas - face and penis
26
TX for psoriasis - Extensive Disease
1. UV light 2. TNF Inhibitors 3. MTX - last resort
27
Pityriasis Rosea Cause
Idiopathic
28
Presentation of Pityriasis Rosea | TX
Single lesion that disseminates Spares palms and soles TX: Steroids, UV light
29
Seborrheic Dermatitis Presentation
Areas w sebaceous glands Scalp, face, chest, intertriginous areas Pruritic, erythematous plaques w fine, loose yellow and greasy looking scales
30
Conditions w increased Seborrheic Dermatitis
1. AIDS | 2. PD
31
Presentation of Torus Palatinus
Benign bony growth - midline of hard palate Fleshy immobile mass Younger pts - 30 yoa, women, asians Non-tender, ulcerates w trauma, heals slowly
32
Presentation Pemphigus Vulgaris
``` Bullae that rupture easily, + Nikolsky Mouth involved Fluid loss/Infxn Painful lesions Not pruritic Pts in 30's, 40's ```
33
Drug Causes of Pemphigus Vulgaris
ACE I Penicillamine Phenobarb PCN
34
Autoabs to what in Pemphigus Vulgaris
Desmogleins
35
Most accurate test for Pemphigus Vulgaris
BX shows autoabs - IgG and C3 in epidermis
36
TX for Pemphigus Vulgaris
1. Systemic steroids 2. Azathioprine or mycophenolate 3. Rituximab or IVIG = refractory
37
Presentation of Bullous Pemphigoid
Urticarial plaques Pruritis Mouth NOT commonly involved 70's, 80's
38
Most accurate test Bullous Pemphigoid
BX shows abs to dermo-epidermal junction/BM | IgG and C3 Linear along BM
39
Drug induced causes of Bullous Pemphigoid
Sulfas NSAIDs Fureosmide Penicillamine
40
TX for Bullous Pemphigoid
Best initial - Prednisone | Mild - erythromycin, dapsone, nicotinamide
41
Presentation of Porphyria Cutanea Tarda
Blisterning sun dz | Back of hands and face involved
42
Porphyria Cutanea Tarda Causes/Assn's
Liver Dz - Hep C, alcoholism, Estrogen use = OCPs Iron overload = hemochromatosis Diabetes
43
Most accurate test Porphyria Cutanea Tarda
Increased uroporphyrins in 24 hour urine collection
44
What is deficient in Porphyria Cutanea Tarda
Uroporphyrin decarboxylase
45
TX for Porphyria Cutanea Tarda
1. Correct underlying problem | 2. Remove iron w phlebotomy
46
Impetigo causes GN and/or Rhematic fever?
GN | NOT RF
47
TX for Impetigo
Mild 1. Mupirocin 2. Bacitracin 3. Repatamulin
48
TX for Community acquried MRSA Impetigo
Doxycycline Clindamycin TMP/SMZ
49
Presentation of Pilonidal cyst
Young males w body hair | Pain, swelling, purulent discharge in midline of post-sacral intergluteal region
50
TX of pilonidal cyst
Drain abscess and excise sinus tract

Derm (3 decks)

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