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MTB 1 Flashcards

1
Q

Worst prognostic factor for Melanoma

A

Growing lesions

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2
Q

Most important prognostic factor

A

Tumor thickness

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3
Q

Best diagnostic test for melanoma

A

Full thickness BX

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4
Q

TX for melanoma

A

Surgical removal

IFN in widespread dz

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5
Q

Where does melanoma mets to

A

Brain

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6
Q

What determines the size of margin excised in melanoma

A

Tumor thickness

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7
Q

Risk factors for SQCC in derm

A

Sunlight
Organ transplant
Long term use of immunosuppressive drugs

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8
Q

Ulcer on lips that does not heal

A

SQCC

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9
Q

Presentation of Basal Cell Ca

A

Waxy lesion

Shiny like a pearl

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10
Q

TX for Basal CC

A

Shave BX

Mohs - esp eyelids, ear

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11
Q

Which virus ass’d with Kaposi

A

HHV-8

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12
Q

Presentation of Kaposi

A 
Older men
Mediterranean
Reddish/purple
GI tract, Lung 
Predominantly AIDS < 100 CD4
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13
Q

Is Kaposi Sarcoma treated w surgical removal

A

No

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14
Q

Tx for Kaposi Sarcoma

A
  1. AIDS - antiretrovirals
  2. Intralesional Vincristine or IFN
  3. Liposomal doxorubicin
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15
Q

Actinic Keratosis - risk of cancer?

A

Yes - premalignant

Small risk for SQCC

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16
Q

TX for actinic keratosis

A 
Must remove w: 
Curettage
Cryotherapy 
Laser 
Topical 5-FU 
Imiquimod
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17
Q

Imiquimod Tx for?

A
  1. Actinic keratosis
  2. Molluscum contagiosum
  3. Condyloma acuminatum
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18
Q

Seborrheic Keratoses Presentation

A

Elderly
Hyperpigmented
Stuck on appearance

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19
Q

Malignant potential for Seborrheic Keratoses?

TX?

A

No.

Tx: removal w cryotherapy, surgery, laser

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20
Q

Atopic Dermatitis Pathophys

Presentation

A

Mast cell overactivity
Asthma, allergic rhinitis, Fam Hx, onset before 5
Pruritis, scratching, scaly rough areas

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21
Q

TX for Atopic Dermatitis

A
  1. Topical Corticosteroids
  2. Tacrolimus and Pimecrolimus
  3. Antihistamines
    Severe = doxepine
  4. ABx - Cephalexin, mupirocin, repatamulim w impetigo
  5. UV light
22
Q

Drugs ass’d with lymphoma

A

Tacrolimus and Pimecrolimus

23
Q

Are psoriasis plaques itchy?

A

Not most of the time

24
Q

Psych issue ass’d with psoriasis

A

Depression

25
Q

TX for psoriasis - Local Disease

A
  1. Topical hi potency steroids
  2. Vit A and Vit D ointment (calcipotriene)
  3. Coal Tar
  4. Tacrolimus and Pimecrolimus on delicate areas - face and penis
26
Q

TX for psoriasis - Extensive Disease

A
  1. UV light
  2. TNF Inhibitors
  3. MTX - last resort
27
Q

Pityriasis Rosea Cause

A

Idiopathic

28
Q

Presentation of Pityriasis Rosea

TX

A

Single lesion that disseminates
Spares palms and soles
TX: Steroids, UV light

29
Q

Seborrheic Dermatitis Presentation

A

Areas w sebaceous glands
Scalp, face, chest, intertriginous areas
Pruritic, erythematous plaques w fine, loose yellow and greasy looking scales

30
Q

Conditions w increased Seborrheic Dermatitis

A
  1. AIDS

2. PD

31
Q

Presentation of Torus Palatinus

A

Benign bony growth - midline of hard palate
Fleshy immobile mass
Younger pts - 30 yoa, women, asians
Non-tender, ulcerates w trauma, heals slowly

32
Q

Presentation Pemphigus Vulgaris

A 
Bullae that rupture easily, + Nikolsky
Mouth involved
Fluid loss/Infxn 
Painful lesions
Not pruritic
Pts in 30's, 40's
33
Q

Drug Causes of Pemphigus Vulgaris

A

ACE I
Penicillamine
Phenobarb
PCN

34
Q

Autoabs to what in Pemphigus Vulgaris

A

Desmogleins

35
Q

Most accurate test for Pemphigus Vulgaris

A

BX shows autoabs - IgG and C3 in epidermis

36
Q

TX for Pemphigus Vulgaris

A
  1. Systemic steroids
  2. Azathioprine or mycophenolate
  3. Rituximab or IVIG = refractory
37
Q

Presentation of Bullous Pemphigoid

A

Urticarial plaques
Pruritis
Mouth NOT commonly involved
70’s, 80’s

38
Q

Most accurate test Bullous Pemphigoid

A

BX shows abs to dermo-epidermal junction/BM

IgG and C3 Linear along BM

39
Q

Drug induced causes of Bullous Pemphigoid

A

Sulfas
NSAIDs
Fureosmide
Penicillamine

40
Q

TX for Bullous Pemphigoid

A

Best initial - Prednisone

Mild - erythromycin, dapsone, nicotinamide

41
Q

Presentation of Porphyria Cutanea Tarda

A

Blisterning sun dz

Back of hands and face involved

42
Q

Porphyria Cutanea Tarda Causes/Assn’s

A

Liver Dz - Hep C, alcoholism,
Estrogen use = OCPs
Iron overload = hemochromatosis
Diabetes

43
Q

Most accurate test Porphyria Cutanea Tarda

A

Increased uroporphyrins in 24 hour urine collection

44
Q

What is deficient in Porphyria Cutanea Tarda

A

Uroporphyrin decarboxylase

45
Q

TX for Porphyria Cutanea Tarda

A
  1. Correct underlying problem

2. Remove iron w phlebotomy

46
Q

Impetigo causes GN and/or Rhematic fever?

47
Q

TX for Impetigo

A

Mild

  1. Mupirocin
  2. Bacitracin
  3. Repatamulin
48
Q

TX for Community acquried MRSA Impetigo

A

Doxycycline
Clindamycin
TMP/SMZ

49
Q

Presentation of Pilonidal cyst

A

Young males w body hair

Pain, swelling, purulent discharge in midline of post-sacral intergluteal region

50
Q

TX of pilonidal cyst

A

Drain abscess and excise sinus tract

Derm (3 decks)

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