MTAP FINALS Flashcards
It’s used for detection of specific infectious agent
Immunology and Serology
Defective immune response/system
Autoimmune disorder
Pertains to the variable region of the antibody
Idiotype
Lyse on the heavy chain structure immunoglobulins
Isotype
Sequence in the constant region
Allotype
It has 2 different chain
Light Chain
It has 22 chromosome
Lambda
Found between CH1 and CH2
Hinge Region
MHC means
Major Histocompatibility Complex
Dictated by several factors. Where antibody producing capability of the antigen when it is present .
Immunogenicity
It considered as a rich source of antigen
Graft Types
Self antigen that belongs to the host.
Autoantigen
Derived from individual’s body/ patient’s own body
Autograft
It’s responsible for the molecular weight of antigen
Carrier portion
Stable, the best and strongest antigen
Protein
Most common carrier is Albumin
Hapten
It can induce an immune response
Immunogen
It enhance the immune response; to have a greater immune reactivity
Adjuvants
Induces the hypersensitivity reactions
Allergen
The immune response is exaggerated that can be harmful to individual
Hypersensitivity
It must be recognized as foreign or non-self to induce immune response
Foreigness
It’s exist in unrelated plants/animals; either identical/closely related in structure
Heterophile antigen
It’s the most fatal (ex. Anaphylaxis/ Severe Asthma)
Type I Hypersensitivity Reaction
It’s the surface of antigens; ABO, Rh antigens
Glycoproteins
Least immunogenic; easily disintegrate in the circulation -> shorter circulation life
Nucleic Acids, Lipids and Amino Acids
It has constant amino acid sequence (constant region) allotype
Carboxyterminal
Capable of antigen binding even without the Fe but cannot agglutinate
Two fab fragments
Responsible for the specific antibody
Variable region
Fragment is crystalline; involved in the Ig biologic function
One Fc fragment
Heavy chains are interconnected
Disulfide linkages
With varying antibody specificity (variable region) Allotype
Aminoterminal
Both light and heavy chains are hold together by:
Covalent disulfide bonds
It’s also known as Immunoglobulins
Antibodies
It’s responsible for cytotropic reaction involving WBC
CH3
It’s connect with receptors in cell membrane
CH3,
Binds with complement protein specifically C1Q
CH2
Found between the CH1 and CH2; flexibility of the antibody
Hinge region
Responsible for the light chain; either kappa or lambda
CL
It enhances the phagocytosis by facilitating the linking/ cross bridging of the phagocytes and the data target antigens
Opsonin
Only antibody with secretory component
IgA
The control of antibody secretion/release in the circulation
Immunoregulation
Only Ig that has specific receptor on mast cells
IgE
It has a 21 to 23 days of life
IgG
What is the molecular weight of IgM
900T
It has 5 Domains
IgM and IgE
It’s responsible for mucosal immunity
IgA
It’s predominant antibody in primary immune response
IgM
Their immune system is already weak
Geriatric patients
An antibody titer that is increasing the logarithmically
Log
Antibody titer degraded
Decline
It occurs in four phases after exposure to an antigen
Primary response
No antibody is detectable
Lag
Antibody titer is stabilizes
Plateau
Other name of secondary response
Anamnestic/memory response
It helps the immune cells to determine self from nonself
Generic control of immune response
Their immune system is different from adults and children
Neonatal
It’s predominant Ig in secretions
Secretory Ig
It binds the basophil and mast cells
Reagenic Ig
It has 2-3 days of life
IgD and IgE
Best agglutinating antibody
Fxn’s
Antibody is transferred from mother to developing baby
Acquired natural passive immunity
It’s damaging and harmful to the baby
HDFN
It will not precipitate /agglutinate the antigens but can only bind the epitope of the antigens
Monovalent type
It produces by B lymphocytes or plasma cells in response to antigen stimulation
Antibodies
GOOD LUCK!!!♥️
