MSK, Skin, CT drugs

Question 1

Enzyme that synthesizes leukotrienes

Answer 1

5-lipoxygenase

Question 2

Zileuton drug MOA

Answer 2

Inhibits 5-lipoxygenase

Question 3

Glucocorticoids MOA

Answer 3

Inhibit Phospholipase A2 and NF-k-beta

Question 4

Celecoxib MOA

Answer 4

COX-2 inhibitor

Question 5

Aspirin MOA

Answer 5

Irreversibly inhibits COX-1 and COX-2

Question 6

Mechanism of NSAIDs

Answer 6

Inhibit COX-1 and COX-2 by covalent acetylation

Question 7

Epoprostenol MOA

Answer 7

Decreases platelet aggregation and vascular tone

Question 8

Alprostadil MOA

Answer 8

Decreases vascular tone

Question 9

Dinoprostone MOA

Answer 9

Increases uterine tone

Question 10

Carboprost MOA

Answer 10

Increases uterine tone

Question 11

Acetaminophen MOA

Answer 11

Reversibly inhibits COX mostly in CNS

Question 12

Acetaminophen hepatic necrosis MOA

Answer 12

Metabolite NAPQI depletes glutathione

Question 13

Treatment for acetaminophen toxicity

Answer 13

N-acetylcysteine - regenerates glutathione

Question 14

Leukotriene receptor antagonist

Answer 14

Montelukast and Zafirlukast

Question 15

Celecoxib side effects

Answer 15

Increased risk of thrombosis; sulfa allergy

Question 16

Celecoxib indications

Answer 16

RA and OA

Question 17

Leflunomide MOA

Answer 17

Reversibly inhibits dihydroorotate dehydrogenase preventing pyrimidine synthesis suppressing T-cell proliferation

Question 18

Leflunomide indications

Answer 18

RA and psoriatic arthritis

Question 19

Leflunomide side effects

Answer 19

Diarrhea, HTN, hepatotoxicity and teratogenicity

Question 20

Bisphosphonates MOA

Answer 20

Pyrophosphate analogs bind hydroxyapatite in bone and inhibit osteoclasts (anti-resorptive)

Question 21

Bisphosphonate indications

Answer 21

Osteoporosis, hypercalcemia, Paget disease, osteogenesis imperfecta, metastatic bone disease

Question 22

Bisphosphonate side effects

Answer 22

Esophagitis, osteonecrosis of jaw, atypical stress fractures

Question 23

Teriparatide MOA

Answer 23

Recombinant PTH analog increases osteoblast activity (increases bone growth)

Question 24

Teriparatide indications

Answer 24

Osteoporosis

Question 25

Teriparatide side effects

Answer 25

Increased risk osteosarcoma and transient hypercalcemia

Question 26

Teriparatide contraindications

Answer 26

Paget disease, high ALP, or prior cancer or radiation therapy

Question 27

Allopurinol MOA

Answer 27

Competitive inhibitor of xanthine oxidase

Question 28

Allopurinol indications

Answer 28

Gout, tumor lysis syndrome, Lesch-Nyhan syndrome

Question 29

Allopurinol side effects

Answer 29

Increases 6-MP concentrations

Question 30

Febuxostat MOA

Answer 30

Xanthine oxidase inhibitor

Question 31

Probenecid MOA

Answer 31

Inhibits resorption of uric acid in proximal convoluted tubule

Question 32

Probenecid side effects

Answer 32

Inhibits secretion of PCN and can precipitate uric acid calculi

Question 33

Pegloticase MOA

Answer 33

Recombinant uricase catalyzes uric acid metabolism to allantoin

Question 34

NSAID that binds and inhibits microtubule polymerization impairing neutrophil chemotaxis and degranulation

Answer 34

Colchicine

Question 35

TNF-alpha side effects

Answer 35

Predispose to infection, reactivation of TB

Question 36

Etanercept MOA

Answer 36

Fusion protein blocks TNF-alpha

Question 37

Etanercept indications

Answer 37

RA, psoriasis, ankylosing spondylitis

Question 38

Infliximab and all other -mab drugs MOA

Answer 38

Anti-TNF-alpha monoclonal antibody

Question 39

Infliximab and all other -mab drugs indications

Answer 39

Psoriasis, Ankylosing spondylitis, IBD, RA (PAIR)