MSK pharm

Question 1

Role of prostaglandins in inflammation

Answer 1

PGI2, PGD2 and PGE2 are vasodilators

(edema, erythema)

Question 2

Role of prostaglandins in pain

Answer 2

PGI2 and PGE2 sensitize nerve endings to bradykinin, histamine and substance P

Question 3

Role of prostaglandins in gastric mucose

Answer 3

PGI2

Question 4

Role of prostaglandings in protection of the gastic mucosa

Answer 4

PGI2

Question 5

Role of prostaglandins in maintenance of renal blood flow

Answer 5

PGE2

Question 6

Role of prostaglandins in platelet aggregation

Answer 6

PGI2 and PGD2 inhibit platelet aggregation

TXA2 stimulates platelet aggregation

Question 7

___________ (prostaglandin) contracts uterus

Answer 7

PGD2

Question 8

__________ keeps ductus arteriosus open following birth.

Answer 8

PGE2

Question 9

Where is COX3 primarily found?

Answer 9

Heart and cerebral cortex

Question 10

3 phases of inflammatory response

Answer 10

Acute transcient

• Local vasodilation and increased capillary permeability

Delayed, subacute

• Infiltration of leukocytes and phagocytic cells

Chronic proliferative

• Tissue degeneration and fibrosis occur

Question 11

Shared characteristics of all NSAIDs

Answer 11

Analgesic, antiinflammatory, and antipyretic

Question 12

Acetylation of COX-2 retains the COX activity although the reaction produces a different product, _________.

Answer 12

15-R-HETE