MSK - Clinical Pharmacology of NSAIDs

Question 1

Describe
- Hypersensitivity
- Pain
- Inflammation

Answer 1

• Exaggerated reactions to stimuli produced by immune system
• When noxious stimuli transmitted to CNS
• Normal response to injury or damage - inactivates and destroys invading organisms - initiating tissue repair. Subsides upon healing

Question 2

(a) Is stimulation of nociceptive endings neurological or chemical in origin?

(b) What are some substances that stimulate pain endings in the skin?

(c) Describe prostanoids.

Answer 2

• Chemical
• Serotonin and kininse.g.bradykinin

Prostanoidsdo notthemselves cause pain
Prostanoidsreleased in inflammationsensitiseC-fibres
Prostanoidsenhancethe pain producing effects of otheragents