MSK 5a: dermatomes, myotomes and segmental innervation of limbs Flashcards
Describe the segmentation of the CNS
Segmented throughout
Each neural segment corresponds to a neural level
What does the embryological neural tube contain?
Precursor cells of the nervous system:
- paired somites (W4: 44 pairs form from paraxial mesoderm, diminishes to about 35 pairs)
- scelrotome (ventral): vertebrae and ribs
- dermatomyotome (dorsal): dermis and muscle
How does the dermatomyotome develop?
Develops in association with a specific neural level of spinal cord (e.g. C6)
Takes the nerve supply with them from the neural tube as a spinal (segmental) nerve, e.g. C6
Skin and muscle derived from a single DMT have a common spinal nerve supply
What is the purpose of spinal nerve roots?
Connect each spinal nerve to a “segment” of cord (the cord is continuous)
What is the difference between dorsal (posterior) and ventral (anterior) spinal nerve roots?
Dorsal: contain only afferent (sensory) nerve fibres. Dorsal root ganglion is the cell bodies of the sensory neurones from the periphery
Ventral: contain only efferent (motor) and autonomic nerve fibres
General structure of spinal nerves?
Parallel bundles of axons encased in connective tissue
Mix of afferent and efferent: ventral and dorsal roots unite in the interventricular foramen
Interventricular foramen marks the division between the CNS and the PNS
General structure of nerves from inner to outer?
Endoneurium
Perineurium
Epineurium
How many pairs of spinal nerves are there and how are they numbered?
31
Numbered according to the level of vertebral column from which they emerge
Vertebral segments
1 vertebra=1 vertebral segment
Differentiate from sclerotomes
Spinal cord runs through vertebral foramina:
-multiple vertebral foramina=spinal canal
-spinal (segmental) nerves leave spinal cord via the intervertebral foramina to become peripheral nerves
Why are nerves referred to as either motor or sensory?
Relate to the majority of fibre types conveyed by that nerve: often have a small number of the other type too, e.g. nerves supplying muscles are mainly motor but have some sensory fibres to convey pain and proprioception
Describe the structure of the spinal cord
Starts at the inferior margin of the MEDULLA OBLONGATA
Terminates as the CONUS MEDULLARIS at L2
Much shorter than vertebral column. Most spinal cord segments are NOT vertically-aligned with the corresponding vertebrae
Long roots from inferior segments (lumbar/sacral/coccygeal) descend in CAUDA EQUINA to exit at their respective foramina
Where do the spinal nerves emerge?
- 1st cervical pair emerge between the occipital bone and atlas (C1)
- C1-C7 exit above the corresponding vertebrae
- T1-L5 exit below the corresponding vertebrae
- S1-S4 exit via 4 pairs of sacral foramina
- S5 and Co1 exit via sacral hiatus (posterior)
What are rami?
Divisions of mixed spinal nerves
Rami communicantes-component of the ANS
What does the posterior/dorsal ramus supply?
Deep muscles and skin of the dorsal trunk (small)
What does the anterior/ventral ramus supply?
Muscles and skin of the upper and lower limbs and the lateral and ventral trunk (large)
Meningeal branch?
Spinal nerves also give off a meningeal branch
This re-enters the spinal cord through the intervertebral foramen
Supplies vertebrae, ligaments, blood vessels and meninges
Structure of dorsal/posterior rami
Divide again into medial and lateral branches
Supply the skin on the back in a “tidy” segmental manner
Narrow strip of muscle/skin in line with intervertebral foramen: supply synovial joints of vertebral column and deep muscles of back