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Antibiotics > MSK > Flashcards

MSK Flashcards

1
Q

Target metabolic pathway (3)?

A
  • Sulfonamides
  • Trimethoprim
  • Paraaminosalicylic acid (PAS)
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2
Q

Target nucleic acid synthesis (3)?

A
  • Rifampin and Rifabutin
  • Quinolones
  • Metronidazole
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3
Q

Disrupt bacterial membranes?

A
  • Polymyxins Colistin
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4
Q

Target Cell Wall (4)?

A

to get over the wall: Frank Drinks Vodka Before

  • Fosfomycin (Phosphomycin)
  • D-Cycloserine
  • Vancomycin
  • Beta-Lactams (Penicillins and Cephalosporins)
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5
Q

Target Formation of Initiation Complexes (1)?

A
  • Linezolid (oxazoldinones)
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6
Q

Target Peptide Chain Synthesis (8)?

A

Silly Seniors Take Cocaine Like My Twin Sister

  • Streptomycin (Aminoglycides)
  • Spectinomycin
  • Tetracyclins
  • Chloramphenicol
  • Lincomycin and Clindamycin
  • Macrolides (Azithromycin, Erythromycin)
  • Telithromycin
  • Streptogramins
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7
Q

Block cell wall synthesis by inhibiting peptidoglycan cross-linking?

A
  • Penicillin
    • ampicillin
    • ticarcillin
  • imipenem
  • aztreonam
  • cephalosporins
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8
Q

Block peptioglycan synthesis?

A
  • Bacitracin
  • Vancomycin
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9
Q

Block DNA topoisomerases?

A

Fluoroquinolones

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10
Q

Block mRNA synthesis?

A

Rifampin

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11
Q

Block protein synthesis at 50S ribosomal subunit (5)?

A

CCELS at 50

  • Chloramphenicol
  • Clindamycin
  • Erythromycin
  • Linezolide
  • Strepptogramins
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12
Q

Block protein synthesis at 30S ribosomal subunit?

A

Buy AT 30

  • Aminoglycosides
  • Tetracyclins
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13
Q

Bacteriostatic antibiotics (6)?

A

We’re ECSTaTiC about bacteriostatics

  • Eythromycin
  • Clindamycin
  • Sulfamethoxazole
  • Trimethoprim
  • Tetracyclines
  • Chloramphenicol
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14
Q

Bactericidal Antibiotics (6)?

A

Very Finely Proficient At Cell Murder

  • Vancomycin
  • Fluoroquinolones
  • Penicillin
  • Aminoglycosides
  • Cephalosporins
  • Metronidazole
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15
Q

Beta-lactams (penicillins and Cephalosporins) inhibit….

A

Transpeptidation

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16
Q

Beta-lactams kill….?

A
  • Gram (+)
    • S. pneumoniae
    • S.pyogenes
    • Actinomyces
  • Syphilis
17
Q

Beta-lactams cause what kind toxicity?

A

Hypersensitivity reactions

Hemolytic anemia

18
Q

Penicillin resistant (nafcillin) antibiotics kill…

A

S. aureus

“use naf for staph”

19
Q

Nafcillin toxicity

A

Hypersensitivity reactions

Nephritis

20
Q

Aminopenicillins (ampicillin and amoxicillin) kill…

A

HELPS kill enterococci

Haemophilus influenzae

E.coli

Listeria monocytogenes

Proteus mirabilis

Salmonella

enterococci

21
Q

Antipsuedomonals are…?

A

Takes Care of Pseudomonas

Ticarcillin

Carbenicillin

Piperacillin

22
Q

Clavulanic Acid is a….

A

Beta-lactamase inhibitor

CAST

clavulanic acid

sulbactam

tazobactam

23
Q

Vancomycin kills…

A

serious resistant organisms

S.aureus

enterococci

C.difficle

24
Q

Vancomycin toxicity…

A

NOT many problems

Nephrotoxicity

Ototoxicity

Thrombophlebitis

“red man syndrome”

25
Q

Aminoglycoside antibiotics

A

“Mean” GNATS canNOT kill anerobes

Gentamicin

Neomycin

Amikacin

Tobramycin

Streptomycin

  • Toxicity
    • Nephrotoxicity
    • Ototoxicity
    • Teratogen
26
Q

Tetracyclins kill…

A

Bobs Burger Has Margo Re-enacting Catz

Borrelia burgdorferi

H.pylori

M. pneumoniae

Rickettsia

Chlamydia

27
Q

Macrolides (name) kill…

A

Eythromycin, azithromycin, clarithromycin

  • Atypical pneumonias
    • mycoplasma
    • chlamydia
    • legionella
  • URIs
  • STDs
  • Nisseria
28
Q

Chloramphenicol kills

A

Meningitis (strep, H. influ)

Lots of toxicity

29
Q

Clindamycin kills…

A

Anerobic infections in aspiration pneumonia or lung abcesses

30
Q

Sulfonamides work with

A

trimethoprim and pyrimethamine

31
Q

Sulfonamides inhibit

A

dihydropteroate synthetase

32
Q

Trimethoprim inhibits…

A

dihydrofolate reducatase

33
Q
A

Antibiotics (1 decks)

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