MSK Flashcards
Target metabolic pathway (3)?
- Sulfonamides
- Trimethoprim
- Paraaminosalicylic acid (PAS)
Target nucleic acid synthesis (3)?
- Rifampin and Rifabutin
- Quinolones
- Metronidazole
Disrupt bacterial membranes?
- Polymyxins Colistin
Target Cell Wall (4)?
to get over the wall: Frank Drinks Vodka Before
- Fosfomycin (Phosphomycin)
- D-Cycloserine
- Vancomycin
- Beta-Lactams (Penicillins and Cephalosporins)
Target Formation of Initiation Complexes (1)?
- Linezolid (oxazoldinones)
Target Peptide Chain Synthesis (8)?
Silly Seniors Take Cocaine Like My Twin Sister
- Streptomycin (Aminoglycides)
- Spectinomycin
- Tetracyclins
- Chloramphenicol
- Lincomycin and Clindamycin
- Macrolides (Azithromycin, Erythromycin)
- Telithromycin
- Streptogramins
Block cell wall synthesis by inhibiting peptidoglycan cross-linking?
- Penicillin
- ampicillin
- ticarcillin
- imipenem
- aztreonam
- cephalosporins
Block peptioglycan synthesis?
- Bacitracin
- Vancomycin
Block DNA topoisomerases?
Fluoroquinolones
Block mRNA synthesis?
Rifampin
Block protein synthesis at 50S ribosomal subunit (5)?
CCELS at 50
- Chloramphenicol
- Clindamycin
- Erythromycin
- Linezolide
- Strepptogramins
Block protein synthesis at 30S ribosomal subunit?
Buy AT 30
- Aminoglycosides
- Tetracyclins
Bacteriostatic antibiotics (6)?
We’re ECSTaTiC about bacteriostatics
- Eythromycin
- Clindamycin
- Sulfamethoxazole
- Trimethoprim
- Tetracyclines
- Chloramphenicol
Bactericidal Antibiotics (6)?
Very Finely Proficient At Cell Murder
- Vancomycin
- Fluoroquinolones
- Penicillin
- Aminoglycosides
- Cephalosporins
- Metronidazole
Beta-lactams (penicillins and Cephalosporins) inhibit….
Transpeptidation
Beta-lactams kill….?
- Gram (+)
- S. pneumoniae
- S.pyogenes
- Actinomyces
- Syphilis
Beta-lactams cause what kind toxicity?
Hypersensitivity reactions
Hemolytic anemia
Penicillin resistant (nafcillin) antibiotics kill…
S. aureus
“use naf for staph”
Nafcillin toxicity
Hypersensitivity reactions
Nephritis
Aminopenicillins (ampicillin and amoxicillin) kill…
HELPS kill enterococci
Haemophilus influenzae
E.coli
Listeria monocytogenes
Proteus mirabilis
Salmonella
enterococci
Antipsuedomonals are…?
Takes Care of Pseudomonas
Ticarcillin
Carbenicillin
Piperacillin
Clavulanic Acid is a….
Beta-lactamase inhibitor
CAST
clavulanic acid
sulbactam
tazobactam
Vancomycin kills…
serious resistant organisms
S.aureus
enterococci
C.difficle
Vancomycin toxicity…
NOT many problems
Nephrotoxicity
Ototoxicity
Thrombophlebitis
“red man syndrome”
Aminoglycoside antibiotics
“Mean” GNATS canNOT kill anerobes
Gentamicin
Neomycin
Amikacin
Tobramycin
Streptomycin
- Toxicity
- Nephrotoxicity
- Ototoxicity
- Teratogen
Tetracyclins kill…
Bobs Burger Has Margo Re-enacting Catz
Borrelia burgdorferi
H.pylori
M. pneumoniae
Rickettsia
Chlamydia
Macrolides (name) kill…
Eythromycin, azithromycin, clarithromycin
- Atypical pneumonias
- mycoplasma
- chlamydia
- legionella
- URIs
- STDs
- Nisseria
Chloramphenicol kills
Meningitis (strep, H. influ)
Lots of toxicity
Clindamycin kills…
Anerobic infections in aspiration pneumonia or lung abcesses
Sulfonamides work with
trimethoprim and pyrimethamine
Sulfonamides inhibit
dihydropteroate synthetase
Trimethoprim inhibits…
dihydrofolate reducatase
