MSK Flashcards

1
Q

What are some hand signs O/E you may see for RA?

A

Tender, stiff and ‘boggy joints’: PIP, MCP, wrist and MTP (toe). Positive squeeze test. Swan neck deformity (DIP flexion, PIP hyperextension). Boutonniere’s deformity (DIP hyperextension, PIP flexion). Z-thumb (CMC flexion, MP hyperextension, IP flexion). Ulnar deviation of MCP joints. Rheumatoid nodules.

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2
Q

What are some hand signs you might see O/E for OA?

A

Heberden’s (DIP) and Bouchard’s (PIP) nodes. Squaring at the base of thumb. Reduced ROM. Weak grip. Crepitus on movement. Joint swelling/effusions.

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3
Q

What are some hand signs you might see O/E for psoriatic arthritis?

A

Psoriatic plaques on skin. Nail pitting: pin prick-like pits. Onycholysis: separation of nail from nail bed. Dactylitis: inflammation of entire finger or toe. Enthesitis (may look at elbow for this).

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4
Q

What are some signs and symptoms of a NOFF?

A

Acute pain in hip/groin – may radiate to knee. Unable to weight bear. Decreased or painful mobility of affected hip. Signs= shortened, externally rotated and abducted left leg. Palpation of the hip and log-roll test (gentle IR-ER) produces pain. Unable to straight leg raise. Bruising + swelling around area.

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5
Q

Before a lower limb fracture is surgically repaired in theatre, how is it investigated/managed?

A

A-E assessment. Analgesia: iliofascial nerve block. VTE prophylaxis (after hip op = LMWH for 28d. Knee= 14d). Imaging (AP + lateral). Immobilise. Treat underlying causes (anaemia, infection, diabetes). If it was a fall investigate why. If open fracture- early ABx prophylaxis + surgical debridement.

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6
Q

How would you interpret an AP pelvis X-ray for a suspected NOFF?

A

Identify Shenton’s line: continuous from medial border of femoral neck to inferior border of superior pubic ramus. Disruption = may be fractured NOF.

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7
Q

For each type of NOFF, how are they surgically repaired?

A

Intracapsular: Undisplaced – internal fixation (plates+screws) or hemiarthroplasty if unfit. Displaced – total hip arthroplasty or hemiarthroplasty if unfit. Extracapsular: Stable intertrochanteric – dynamic hip screw. Subtrochanteric or unstable – intramedullary device, i.e. nail.

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8
Q

How might a dislocated hip present + how is it investigated?

A

Sx= pain, popping sound, inability to weight bear, sensation changes to posterior leg/foot. Signs= internal rotation, adduction, shortening of limb, local haematoma, reduced deep tendon ankle reflex. Lateral + AP view of hip (X-ray) + CT scan to assess for acetabular fractures.

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9
Q

How would you manage a dislocated hip? What are some potential complications?

A

Closed reduction, ideally within 6h (i.e. Allis technique – traction applied in line with deformity), under sedation or GA. Open reduction, if closed reduction fails or there is an associated fracture. Complications= AVN of femoral head, post-traumatic arthritis or recurrent dislocations, sciatic nerve injury.

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10
Q

What is the Garden system classification for hip fractures?

A

Type I: incomplete fracture + non-displaced. Type II: complete fracture + non-displaced. Type III: complete fracture, incomplete displacement but still has boney contact (usually rotated + angulated). Type IV: complete fracture + complete displacement, i.e. bone disruption.

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11
Q

What is fat embolism syndrome? What is Gurd’s major and minor criteria?

A

Can occur after fracture of long bones, i.e. femur. Fat globules -> circulation, become lodged in BVs = BF obstruction. Leads to systemic inflammatory response (usually 24-72h after fracture). Major criteria = respiratory distress, petechial rash, cerebral involvement. Minor= jaundice, thrombocytopenia, fever, tachy.

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12
Q

What is compartment syndrome? What are the s+s, investigation + management?

A

Increased pressure in myofascial compartment= impairs perfusion = ischaemia and necrosis. 5 P’s: pain (disproportionate + excessive use of breakthrough analgesia), paraesthesia, pallor, pressure (high) and paralysis. Pulselessness= differentiates it from acute limb ischaemia. Key hint= recent trauma or procedure with disproportionate pain + pain exacerbated by passive stretch. M/c in supracondylar or tibial shaft fractures. Ix= clinical, raised CK. Mx= emergency fasciotomy (within 6h), irrigation + debridement.

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13
Q

What is the Weber classification for lateral malleolus ankle fractures? How are they managed?

A

Type A: below the ankle joint - will leave the syndesmosis intact (boot or cast). Type B: at the level of the ankle joint - syndesmosis will be intact or partially torn (OR + IF, cast after surgery). Type C: above the ankle joint - syndesmosis will be disrupted (OR + IF, cast after surgery).

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14
Q

What is a Colle’s fracture? How might it present?

A

Transverse fracture of the radius; dorsal displacement of distal radius (+ angulation). Usually results from FOOSH + common fragility fracture. Wrist pain and swelling. Dinner fork deformity of the wrist. Paraesthesia and weakness- can damage median nerve (=carpal tunnel).

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15
Q

How is a Colle’s fracture investigated + managed?

A

X-ray: AP and lateral views; can see transverse fracture of distal radius (2.5cm proximal to radio-carpal joint). If complex – CT or MRI. Usually: Closed reduction with immobilisation with a plaster cast for 4-6 weeks – then repeat the X-ray. If complex or unstable = ORIF or closed reduction and K-wiring.

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16
Q

What is a Smith’s fracture? How is it often caused + managed?

A

Volar angulation of distal radius fragment (= garden spade deformity). Caused by falling backwards onto the palm of an outstretched hand or falling with wrists flexed. Management = ORIF with plates and screws (volar displacement= always unstable and requires surgical fixation).

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17
Q

What are the symptoms and 5 key signs of a scaphoid fracture? How is it usually caused?

A

FOOSH or contact sports. Sx= pain along radial aspect of wrist and loss of grip/pinch strength. 5 key signs: 1) Point of maximal tenderness is over the anatomical snuffbox. 2) Wrist joint effusion: unless hyperacute (<4h) or delayed (>4d old). 3) Pain elicited by telescoping the thumb (longitudinal compression). 4) Tenderness of scaphoid tubercle. 5) Pain on ulnar deviation of wrist.

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18
Q

How is a scaphoid fracture investigated? What are the potential complications of a scaphoid fracture?

A

A-E, analgesia, immobilise with Futuro splint. X-ray (AP+lateral). If X-ray inconclusive, immobilise + refer for MRI/CT 7-10 days later. Complications: AVN of scaphoid (m/c with proximal fractures- disrupt retrograde blood supply). Non-union -> early OA.

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19
Q

How is a scaphoid fracture surgically managed?

A

Undisplaced= cast for 6-8 weeks. Displaced= surgical fixation. Proximal scaphoid pole fracture = surgical fixation.

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20
Q

What is a Galeazzi and Monteggia’s fracture?

A

Galeazzi= radial shaft fracture with dislocation of distal radioulnar joint. Monteggia’s = ulnar shaft fracture with dislocation of proximal radioulnar joint.

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21
Q

What are the typical cancers that metastasise to bone?

A

Prostate, renal, thyroid, breast and lung.

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22
Q

Which bones are at greatest risk of avascular necrosis?

A

Scaphoid bone, femoral head, humeral head, talus, navicular, 5th metatarsal in the foot.

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23
Q

What are the expected lab values of calcium, phosphate, ALP and PTH for the following conditions: a. Osteoporosis b. Osteomalacia c. Primary hyperparathyroidism d. Secondary hyperparathyroidism (CKD) e. Paget’s disease

A

A) Normal for all. B) Decreased calcium + phosphate, increased ALP + PTH. C) Increased calcium, decreased phosphate, increased ALP + PTH. D) Decreased calcium, increased phosphate, ALP, PTH. E) Isolated rise in ALP (everything else normal).

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24
Q

Give the WHO criteria for osteoporosis and osteopenia. What is a Z-score and T-score?

A

T-score >-1 SD below mean = normal, -1 to -2.5 = osteopenia, <-2.5= osteoporosis [considered severe if this is present + fracture]. T-score= compares against healthy young adult aged 20-35 (same race+sex). Z-score= compares against someone same gender + age.

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25
What are some side effects of bisphosphonates? And what drugs are first + second line for osteoporosis?
Reflux + GI discomfort (common). Atypical fractures, e.g. femoral fracture (rare). Osteonecrosis of jaw or of external auditory canal (rare). First line = alendronate or risedronate, or if hip fracture = IV zoledronate (yearly). Second line = denosumab (monoclonal AB, blocks activity of osteoclasts).
26
In which patients is a DEXA scan not required before prescribing bisphosphonates?
Postmenopausal women and men 50+ who: are treated with steroids of 7.5mg+/day prednisolone (or equivalent) for 3+ months, have a symptomatic osteoporotic vertebral fracture. Women aged 75+ who have a fragility fracture.
27
What is the Salter-Harris classification for growth plate fractures (paediatric)?
The higher the grade, the more likely it will disturb growth. Use SALTER mnemonic: Type 1: Straight across – physis only. Type 2: Above – involves physis + metaphysis. Type 3: Lower (or below) – physis + epiphysis. Type 4: Through – involves all 3. Type 5: Crush. Despite a normal X-ray, growth plate tenderness is indicative of an underlying fracture.
28
How are paediatric fractures managed/treatment?
1) Mechanical alignment – CR or OR. 2) Relative stability – external casts, K wires, IM nails etc. Pain ladder: 1) paracetamol or ibuprofen, 2) Morphine (usually admission) – DON’T use codeine or tramadol in children. NAI = radial (unless distal), humeral, femoral.
29
What is osteogenesis imperfecta and what are the typical s+s?
"Brittle bone disease" – group of disorders of collagen metabolism= bone fragility + fractures. Treat w bisphosphonates + vit D. S+s= usually presents in childhood. hypermobility, blue sclera, deafness (due to otosclerosis), triangular face and short stature, fragility fractures.
30
For osteoarthritis, what are the: a. Risk factors b. Common joints affected c. Presentation d. Signs O/E (apart from hand signs)
RFs= age, obesity, trauma, female, FH. Joints= hips, knees, DIPs (hands), CMC (thumb base), lumbar spine, C-spine (‘cervical spondylosis’). Presentation= joint pain + stiffness, worse after activity + at end of day. Morning stiffness lasts <30 minutes. Signs = bony enlargement of affected joints, restricted ROM (pain), crepitus on movement, joint effusions.
31
What changes may be seen on X-ray for osteoarthritis? What other investigations may be done?
Loss of joint space. Osteophytes (bone spurs). Subarticular sclerosis (increased bone density along joint line). Subchondral cysts. CRP/ESR (exclude inflammatory arthritis), MSK USS (osteophytes, effusions), MRI (early OA changes).
32
How is OA managed?
Conservative= education, exercise, weight loss, OT referral. Medication= topical NSAIDs 1st line, oral NSAIDs + PPI (2nd line), paracetamol + weak opioids (only ST), intra-articular steroid injections (temporary relief). Surgical= joint replacement if severe.
33
For RA: a. What is it? (brief) b. Risk factors c. Antibodies associated
Autoimmune systemic condition, causes inflammation in synovial lining of joints (inflammatory arthritis) and extra-articular features. RFs= smoking, obesity, HLA-DR4 and DR1, female, FH. Antibodies= anti-CCP and RF.
34
How does RA present?
Symmetrical joint pain, stiffness and swelling (lasts >30 mins in morn [usually 60]). Affects small joints of hands (PIP, MCP) + feet (MTP) + wrist. Stiffness may improve with activity. Low-grade fever and fatigue. Other systemic sx = weight loss, malaise, flu-like illness.
35
What are the antibodies associated with RA?
Anti-CCP and RF.
36
How does RA present?
Symmetrical joint pain, stiffness, and swelling (lasts >30 mins in morning, usually 60). Affects small joints of hands (PIP, MCP), feet (MTP), and wrist. Stiffness may improve with activity. Low-grade fever and fatigue. ## Footnote Other systemic symptoms include weight loss, malaise, and flu-like illness.
37
What are some extra-articular manifestations of RA?
Pulmonary fibrosis, bronchiolitis obliterans, vasculitis, Sjogren’s syndrome, cardiovascular disease, anemia of chronic disease, Felty’s syndrome (RA, splenomegaly, and low WBC), episcleritis, scleritis, keratitis.
38
How is RA investigated and diagnosed?
Bedside: urine dip (hematuria/proteinuria) + obs. RF + anti-CCP antibodies (more specific) + ANA (check for SLE). CRP/ESR, FBC ± uric acid (rule out gout). X-ray hands and feet. USS (or MRI) to detect synovitis if examination findings unclear. Diagnosed using ACR criteria (score 6+/10 = diagnostic).
39
What are the X-ray findings of RA?
SPADES mnemonic: Soft-tissue swelling, peri-articular erosions/osteopenia (late), absent osteophytes, deformity, erosions (late feature), subluxation (late), loss of joint space. Important sign: juxta-articular osteoporosis.
40
What information should be shared with a patient diagnosed with RA?
Flare-ups can occur when stressed or during infections. Due to increased CVD risk, need to monitor BP and give healthy lifestyle advice (stop smoking, exercise, diet). Greater risk of infection. Risk of lung and heart problems – come in if chest pain, shortness of breath, or cough. Eyes can be affected – red, painful, or dry eyes. If medication doesn’t work, last resort can be joint replacement.
41
What is the stepwise pharmacological management of RA?
1st line: DMARD monotherapy ± short course steroid (usually first presentation to settle, + PPI). Methotrexate (most common), leflunomide, sulfasalazine, or hydroxychloroquine if mild. Regular review in 4-6 weeks, monitor response with DAS28 or CRP. 2nd line: combination of any of the above 2. 3rd line: methotrexate + biologic therapy (etanercept, infliximab, adalimumab). 4th line: methotrexate + rituximab (monoclonal antibody). Mention it is an MDT approach.
42
What are some side effects of methotrexate?
Risk of myelosuppression (low WBC, RBC, and platelets), liver cirrhosis, and toxicity. Common side effects include hair loss, headaches, mouth ulcers, upset tummy (diarrhea, nausea & vomiting), drowsiness. Nausea, vomiting, and diarrhea can be reduced if taking folic acid. Teratogenic – avoid 6 months before conception.
43
What information should be told to a patient when prescribing methotrexate?
Taken weekly + take folic acid 5mg a few days apart (Monday for methotrexate, Friday for folic acid). Long-term medication – usually takes 4-6 months to reach optimal effects. Blood tests before and biweekly to monitor for side effects (then can be less frequent). Serious side effects include easy bruising, yellowing of skin, feeling short of breath, or looking pale. Avoid 6 months before conception. Avoid NSAIDs (ibuprofen and aspirin). Get annual flu jab. Reduce alcohol to 6 units/week ideally, use sunblock, and reduce caffeine. Never take 2 doses together; if a dose is missed, contact the doctor.
44
What are some side effects of hydroxychloroquine?
Common side effects include stomach pain, nausea & vomiting, skin rash, loss of appetite, headache. Retinal toxicity – vision loss – see doctor if there is a change in eyesight. Blue-grey skin pigmentation and hair lightening (bleaching).
45
What information should be told to a patient taking hydroxychloroquine?
Works by calming your immune system to reduce inflammation. Can take 6-12 weeks to work, important to keep taking it. Baseline ophthalmology review and annual screening after 5 years of drug use. Regular blood tests (FBC). Safety net: eye problems, easy bruising, signs of low blood sugar (sweating, dizziness). Can be used during pregnancy. Tell doctor if feeling unwell (e.g., sore throat or fever). Take with or just after food, with a glass of milk. Never take 2 doses at the same time to make up for a missed dose.
46
What is gout?
Crystal arthropathy caused by chronically high uric acid levels in blood, leading to inflammation in joints. Risk factors include male gender, family history, obesity, high purine diet (meat), alcohol consumption, diuretics, cardiovascular disease, and renal disease.
47
What are the signs and symptoms of gout?
Acute, hot, swollen, and painful joint (max intensity in 12 hours). Commonly affected joints include the 1st MTP, CMC (thumb), and wrist. On examination: warmth, erythema, gouty tophi (hands - DIP, ears, and elbows).
48
How is gout investigated?
Clinical assessment + raised serum urate levels. Joint aspiration (to exclude septic arthritis) shows monosodium urate crystals that are needle-shaped and negatively birefringent under polarized light. X-ray of the affected joint shows maintained joint space, lytic lesions in bone, and punched-out erosions (sclerotic borders, overhanging edges).
49
How is gout managed?
If septic arthritis is suspected, start IV antibiotics while waiting for investigations. Lifestyle changes include weight loss, hydration, and dietary modifications. Acute treatment includes NSAIDs + PPI (1st line), colchicine (if NSAIDs are contraindicated), and steroids (3rd line). Prophylaxis includes allopurinol or febuxostat after the acute attack has resolved.
50
What is pseudogout?
Crystal arthropathy caused by calcium pyrophosphate crystals in joints (chondrocalcinosis). Risk factors include hemochromatosis, hyperparathyroidism, acromegaly, Wilson’s disease, low magnesium and phosphate levels, and older age.
51
What are the signs and symptoms of pseudogout?
Can be asymptomatic or present with chronic pain and stiffness in one or more joints (can be acute). Commonly affected joints include knees, wrists, and shoulders. Older patients may have fever and confusion (rule out septic arthritis).
52
How is pseudogout investigated and managed?
Joint aspiration shows calcium pyrophosphate crystals that are rhomboid-shaped and positively birefringent under polarized light. X-ray shows chondrocalcinosis (thin white line in the middle of the joint space) and similar signs to osteoarthritis. Management includes NSAIDs + PPI, colchicine, intra-articular steroids, and oral steroids.
53
How might reactive arthritis present?
Presents with acute arthritis (warm, swollen, painful joint), urethritis, and conjunctivitis. Commonly affects the knee, ankles, and feet. Triggered by chlamydia or gastroenteritis within 4 weeks.
54
How is reactive arthritis investigated and managed?
Diagnosis is clinical + HLA-B27 antigen + NAAT for chlamydia. Treatment includes hot joint policy (antibiotics – treat as septic arthritis until excluded), NSAIDs, and intra-articular steroids (rarely oral).
55
What is septic arthritis caused by?
Caused by haematogenous spread from distant infection (e.g., abscess).
56
What are the risk factors and signs/symptoms of septic arthritis?
Risk factors include IV drug use, skin ulcers, immunosuppression, joint prostheses, RA, and OA. Symptoms include acute, painful, swollen joint, fever, lethargy, and rigors. On examination: loss of range of motion, warmth, erythema, and non-weight bearing.
57
How is septic arthritis investigated and managed?
Investigations include swabs for N. gonorrhoeae, FBC, CRP, ESR, blood culture, and joint aspiration (US guided if hip joint). Management includes empirical IV antibiotics ASAP after aspiration + gram staining (IV flucloxacillin, clindamycin if allergic, ceftriaxone if N. gonorrhoeae). After culture returns, guided antibiotic therapy is provided. Analgesia and sepsis 6 protocol are also important.
58
What are the seronegative spondyloarthropathy conditions?
Group of inflammatory rheumatic conditions affecting axial and peripheral joints, causing enthesitis. RF negative. Conditions include psoriatic arthritis, ankylosing spondylitis, reactive arthritis, and IBD-associated arthritis.
59
What are the common patterns for how psoriatic arthritis presents?
Most commonly presents as symmetrical distal polyarthritis (similar to RA but MCP usually spared). Other patterns include asymmetrical polyarthritis, spondylitic/sacroiliitis, and arthritis mutilans (severe osteolysis of bone). Psoriatic arthropathy can occur before skin lesions.
60
What are some common features on examination for psoriatic arthritis?
Psoriatic skin lesions/plaques, enthesitis, dactylitis, nail pitting, and onycholysis.
61
How is psoriatic arthritis investigated and managed?
Use the PEST screening tool for patients with psoriasis; if high, refer to rheumatology. Test for RF to rule out RA. X-ray shows pencil-in-cup appearance, periostitis, ankylosis, and osteolysis. Management includes NSAIDs for pain, DMARDs (methotrexate), anti-TNF (etanercept, infliximab), ustekinumab (monoclonal antibody), and intra-articular steroids for flares.
62
What are the signs and symptoms of ankylosing spondylitis?
Typically affects males under 40, presenting with low back pain and stiffness, sacroiliac pain (buttock region), nighttime pain, stiffness worse in the morning (>30 mins) and rest, improving with exercise. Other features include chest pain, shortness of breath, enthesitis, and dactylitis.
63
What are the associated conditions/presentations of ankylosing spondylitis?
Associated conditions include aortic regurgitation, anterior uveitis, achilles tendinitis, apical lung fibrosis, anemia of chronic disease, and AV block.
64
How is ankylosing spondylitis investigated and managed?
Investigations include CRP/ESR, HLA-B27, X-ray (most useful for diagnosis), and possibly CXR (for apical fibrosis). If X-ray is normal, MRI spine may show bone marrow edema (early). Management includes NSAIDs for 2-4 weeks; if not adequate, switch to another NSAID. Steroids for flares (oral or IM), anti-TNF (etanercept), monoclonal antibodies (infliximab), and non-medication options like physiotherapy (swimming), avoiding smoking, bisphosphonates, and surgery if spinal deformity occurs.
65
What are the X-ray signs seen in ankylosing spondylitis?
Signs include squaring of vertebrae, ossification in ligaments, joints, and discs, subchondral sclerosis and erosions (sacroiliitis), syndesmophytes (areas of bone growth where ligaments insert), fusion of facet, sacroiliac, and costovertebral joints (reduced range of motion), and bamboo spine (late feature).
66
What is the most common type of juvenile arthritis and how does it present?
Pauciarticular (oligarticular): involves 4 joints or less (usually 1), lasts for <6 weeks (patients <16). No systemic symptoms apart from fatigue. Affects large joints: knees, ankle, elbow, causing pain and stiffness, possibly a limp. ANA positive but RF negative. Anterior uveitis is a feature, requiring ophthalmology referral. Most common in girls <6 years.
67
What is Still’s disease and what are the signs and symptoms?
Systemic juvenile idiopathic arthritis (JIA) (i.e., <16 years, lasting >6 weeks) – can also occur in adult-onset Still’s disease. Symptoms include salmon-pink rash, fever, joint pain, enlarged lymph nodes, and splenomegaly. Complication includes macrophage activation syndrome (acutely unwell child, DIC).
68
What might blood tests show in Still's disease?
Raised CRP, ESR, platelets, and serum ferritin.