MSK

Question 1

Epidemiology and risk factors for osteosarcima

Answer 1

Child/adolescence
Male

Paget’s disease in older adults
FHx
Radiotherapy

Question 2

Presentation of osteosarcoma

Answer 2

Worsening deep boring pain over weeks to months (more severe at rest/night)

Mass/swelling
Limited ROM
Limp
Pathological #

Question 3

Dx of osteosarcoma

Answer 3

XR: radiolucent lesion, periosteal reaction in form of Codman’s triangle or a sunburst appearance is common

MRI of primary tumour

CT thorax
Radionuclide bone scan
FDG-PET

Serum: ALP, LDH