MSK Flashcards
chronic pain at multiple sites - 'pain all over' lethargy cognitive impairment sleep disturbance dizziness headache
fibromyalgia
diagnosis of fibromyalgia
11/18 tender points
management of fibromyalgia
Gabapentin and amitriptyline
CBT and aerobic exercise can also be useful
severe pain
erythema
swelling
usually the 1st MTP joint affected
hx of high purine diet, thiazide use and excessive alcohol/dehydration
gout
investigation for gout
joint aspiration and crystal analysis
negatively birefringent crystals
management for gout
acute = NSAIDs (& appropriate gastroprotection)
colchicine can be given but slower to act
chronic = allopurinol, might start with colchicine
second line = febuxostat
pain mainly in the hip and shoulder pain/aching in the morning stiffness in the proximal limbs polyarthralgia lethargy depression low grade fever
polymyalgia rheumatica
Ix for PMR
ESR/CRP
management of PMR
prednisolone
episodic attacks of hot, swollen joints. Typically knee is affected
pseudogout
investigation of pseudogout
aspiration = positively birefringent crystals - rhomboid
(exclude septic arthritis)
calcium pyrophosphate
management of pseudogout
IA steroid injection
NSAIDs
arthritis uveitis urethritis fever dactylitis
hx of GI/GU infection 1-4 weeks prior
usually male and HLA-B27
reactive arthritis/reiter’s syndrome
management of reactive arthritis/reiter’s syndrome
NSAIDs first line
steroid second line
persistent disease = sulfasalazine and methotrexate
usually in 20-30s , more common in females
multiple, peripheral joins - MCPs and PIPs
symmterical, joint pain and stiffness
stiffness worse in the morning - improves with as the day goes on
positive squeeze test
rheumatoid arthritis
Diagnosis of rheumatoid arthritis
anti-CCP
X - rays = erosions
management of rheumatoid arthritis
DMARDs - methotrexate/sulfasalazine
- usually taken with folic acid
start with bridging steroids
give steroids IM/PO in acute flares
TNF-a/biologics in inadequate responses
Fever, malaise and arthralgia HTN peripheral motor neuropathy livedo reticularis weight loss
commonly with 40-60yrs old and Hep B infections
polyarteritis nodosa
Ix for polyarteritis nodosa
biopsy = full thickness necrotizing inflammation
raised ESR/CRP
normocytic, normochromic anaemia
management of polyarteritis nodosa
steroids
+/- DMARDs
common in knee and DIPs
usually mono/oligoarthritis - asymmetrical
dactylitis
pitting nails
swelling of associated tendons - enthesis
dry erythematous skin
psoriatic arthritis
Ix of psoriatic arthritis
X-ray hands and feet = pencil in cup deformity
ESR/CRP raised
management for psoriatic arthritis
mild cases = NSAIDs
DMARDs and immunosuppressants - TNFa inhibitors
severe dry eyes and dry mouth fatigue arthralgia Raynauds phenomenon vaginal dryness recurrent parotitis positive schimer's test
Sjogren’s syndrome