MSK 1 Flashcards
What does CREST stand for?
Calcinosis Raynaud Esophageal dysmotility Schlerodactyly Telangectasia
What Abs are found in scleroderma?
Anti-Scl-70
Anti-DNA topoisomerase I
What’s the difference between Lambert-Eaton and Myasthenia Graves?
Lambert: Abs against presynaptic Ca channels, gets better with use.
MG: Abs against post synaptic ACh receptors. Gets worse with use.
What are some findings in Sarcoidosis.
Non-caseating granuloma. Restrictive lung disease Bell's palsy Uveitis Erythema nodosum
What infections are associated with reactive arthritis (aka- Reiters ryndrome)
Conjunctivitis
Urethritis
Arthritis
“Can’t see, can’t pee, can’t climb a tree”
What are the Abs for Sjogren’s Syndrome
Anti-RNP
Anti-SSA (ro)
Anti-SSB (La)
What are the Abs for Lupus?
Anti-ANA: Sensitive
Anti-dsDNA: Specific
Anti-Sm: Specific
*Watch out for Anti-Phospholipid which can give false positive VDRL, and prolonged PTT in vitro even though you’re hypercoaguable in vivo.
Gout vs. Psuedogout
Gout: negative birefringence (yellow in parallel light), uric acid crystals, needle-shaped, big toe, after steak/beer.
Pseudo: weakly positive birefringence (blue in parallel light), calcium pyrophosphate crystals, rhomboid, affects knee (big joints).
What two bone disease have completely normal lab values?
Osteoporosis, osteopetrosis
What disease only has an elevated ALP?
Pagets
What are the lab values for osteomalacia/rickets?
PTH: up
ALP: up
PO4: down
Ca2+: down
What are the lab values for Hypervitaminosis D?
PTH: down
ALP: -
PO4: up
Ca2+: up
What has soap bubble appearance on x-ray, multinucleated giant cells, and is a locally agrressive tumor at the epiphyseal end of long bones?
giant cell tumor
What looks like a mushroom in the metaphysis of long bones?
osteochondroma
What is the 2nd most common primary malignant bone tumor, with bimodal age distribution? It also has Codman’s triangle? Treat with resection and chemotherapy.
Osteosarcoma (osteogenic sarcoma)
