MS Test 2 Flashcards
Third most common form of cancer 9% of cancer deaths are due to CRC More common in men Highest mortality rates among African American men and women Risk of contracting the disease increases with age Of new cases, 90% in people older than 50 The incidence of CRC in individuals older than 50 is decreasing as a result of increased screening to detect precancerous lesions
Colorectal Cancer
has an insidious onset, and symptoms do not appear until the disease is advanced. Regular screening is necessary to detect precancerous lesions. Approximately one half of all colon cancers occur in the rectosigmoid area
Colorectal Cancer
CRC Mortality rates are highest among _____ and _____. About 90% of new CRC cases are detected in people older than 50, and about a third occur in patients with a family history of CRC.
African American men and women.
Diet Risk factors for CRC
High in red or processed meat
Low in fruits and vegetables
Lifestyle factors for CRC
Obesity
Physical inactivity
Alcohol
Long-term smoking
How can we decrease the risk of CRC?
Physical exercise and a diet with large amounts of fruits, vegetables, and grains may decrease the risk.
NSAIDs (e.g., aspirin) in women also may decrease the risk.
Most common type of CRC
Adenocarcinoma is the most common type of CRC About 85% arise from adenomatous polyps Tumors spread through the walls of the colon into musculature and into the lymphatic and vascular systems
Most common sites for metastasis of CRC
Most common sites of metastasis
Regional lymph nodes
Liver
Lungs
Bones
Brain
Why is the liver a common site of metastasis from CRC?
Because venous blood leaving the colon and rectum flows through the portal vein and the inferior rectal vein,
Clinical manifestations of CRC?
Insidious onset .
Symptoms often do not appear until disease is in advanced stages.
Change in bowel habits
Unexplained weight loss
Vague abdominal pain
Symptoms of cancer in the left side of the colon appear earlier
Symptoms of cancerous lesions (CRC)
Rectal bleeding is most common
Alternating constipation and diarrhea
Change in stool caliber
Narrow, ribbon-like
Sensation of incomplete evacuation
Obstruction
Manifestations of CRC
Weakness and fatigue
Iron-deficiency anemia
occult bleeding
Complications of CRC
Obstruction
Bleeding
Perforation
Peritonitis
Fistula formation
Signs and symptoms of CRC based on location: Transverse Colon
Pain
obstruction
change in bowel habits
anemia
Signs and symptoms of CRC based on location: Descending Colon
Pain
change in Bowel habits
Bright red blood in the stool
obstruction
Signs and symptoms of CRC based on location: Rectum
Blood in stool
Change in bowel habits
Rectal Pain
Signs and symptoms of CRC based on location: Ascending Colon
Pain
mass
change in bowel habits
anemia
At what age should person get a colonoscopy?
Beginning at age 50, both men and women at average risk for developing CRC should undergo screening tests to detect both polyps and cancer
Where do most CRC come from?
Most CRC arises from adenomatous polyps. Therefore, early detection and removal of precancerous polyps could prevent most CRC
CT colonography
is also called virtual colonoscopy.
How often should diagnostic tests be done for CRC?
Regular screening for polyps and cancer Flexible sigmoidoscopy every 5 years Colonoscopy every 10 years Double-contrast barium enema study every 5 years CT colonography every 5 years
Annual screening tests for CRC?
Annual screening primarily for cancer.
Fecal occult blood test (FOBT)
Fecal immunochemical test (FIT) Test for blood in the stool Must be done frequently to catch the intermittent bleeding common with tumors