MS Drugs Flashcards
Injectable Interferon beta
Avonex
Injectable Glatiramer acetate
Copaxone
Avonex
Injectable Interferon Beta 1a/b
Moa: Inhibit proinflammatory WBCs from crossing BBB
Decrease relapse by 30%
AE:
- Flu like
- Liver toxicity
- Bone marrow suppression
- Depression
- Drug interactions
Copaxone
Injectable Glatiramer acetate
MOA: Increased production of Anti-inflammatory T-Cells which cross the BBB and suppress inflammation
AE:
Injection site reactions
Post Injection:
- Flushing, palpitations, chest pain, rash, laryngeal constriction (15-20 mins)
- NO treatment required*
MS: Oral Disease Modifiers
fingolimod
dimethyl fumarate
MS: Infusion Disease Modifiers
natalizumab
fingolimod
Oral Disease Modifier
RRMS
MOA: retains lymphocytes in lymph nodes
-Preventing them from crossing the BBB DECREASING INFLAMMTION
dimethyl fumarate
Oral Disease Modifier
MOA: Inhibit immune cells and may have anti-oxidant properties
Natalizumab
Infusion Disease Modifier
RRMS
(reduces relapse by 68%) + Crohn’s
-MONOTHERAPY
MOA: Prevents circulating T cells from leaving VASCULATURE and crossing the BBB
Natalizumab AE
Headache + Fatigue
(PLM) Progressive multifocal leukoencephalopathy
- TOUCH program
- Big risks when combined with other drugs (MONOTHERAPY ONLY)
Hepatotoxicity
Hypersensitivity
What drug is used for patients with poor response to 2 or more MS meds?
Alemtuzumab
Used for:
- Secondary progressive
- Progressive-relapsing
- Worsening RRMS
mitoxantrone
Drugs used for ACUTE RELAPSE of MS
- High dose IV Glucocorticoid
- 500mg-1g methylprednisolone 3-5x daily
- Do not use long term or frequently - IV Gamma Globulin
- Used for patients intolerant to glucocorticoids (steroids) - ACTH
- Adrenocorticotropic hormone in GEL form
- Extended release
- For people unable to tolerate steroids or they haven’t worked - Plasma Phoresies
- replacing your plasma w/donor plasma
MS: Fatigue
Amantadine
MS: Muscle relaxants
Muscle spasms
