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Rotation Prep Mod 3 > MS agent(s) > Flashcards

MS agent(s) Flashcards

1
Q

Gilenya (Fingolimod) class

A

Sphingosine 1-Phosphate (S1P) Receptor Modulator

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2
Q

Gilenya (Fingolimod) MOA

A

Binds S1P receptors 1,3,4,&5 -> blocks lymphocytes ability to emerge from lymph nodes, reducing the number of lymphocytes available to the CNS

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3
Q

Gilenya (Fingolimod) altered kidney function

A

no dose adjustment necessary

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4
Q

Gilenya (Fingolimod) hepatic impairment

A

Child-Pugh class C : no dose adjustments, but use with caution and monitor closely

ALT > 3 times ULN and total bilirubin > 2 times ULN : DC fingolimod treatment

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5
Q

Normal ALT levels

A

4-36 U/L

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6
Q

Normal total bilirubin

A

0.1-1.2 mg/dL

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7
Q

Gilenya (Fingolimod) ADE

A
  • abd pain, diarrhea, nausea
  • influenza
  • HA
  • cough, sinusitis
  • altered LFTs
  • CV: bradycardia, 1st degree AV block, HTN
  • alopecia, basal cell carcinoma of skin
  • leukopenia
  • blurred vision
  • bronchitis, dyspnea
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Rotation Prep Mod 3 (4 decks)

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