MS Flashcards
Multiple Sclerosis is a ______ disease
Demyelinating
What do demyelinating dis’s do and what is the MOST COMMON form?
- DEC speed and quality of impulse conduction (saltatory conduction)
- MS is most common form
Demyelination can occur due to:
- Systemic disease
- Malnutrition
- Toxic exposure
- Infection
- Anoxia→ deprivation of O2
- Ischemia→ local
MS Defined:
Demyelinating dis. characterized by a course of demyelination relapses & remissions, superimposed upon gradual neurologic deterioration
Keep in mind w/ MS:
ANY CNS white matter can be affected→ presentation will vary
*episodic AND chronic
MS Prevalence
Female > Male; 2:1 ratio
MS High Risk Areas
FURTHER AWAY FROM EQUATOR
- Northern US, Northern Europe, Southern Canada, New Zealand, Southern Australia
MS Etiology:
Interaction b/w genetic predisposition & an inciting environmental antigen→ produces autoimmune demyelinating response in susceptible host
Theory of autoimmune response in MS:
CNS myelin becomes infected by virus and is perceived as antigen
*immune system then targets the “antigen” aka destroys myelin
Stress and MS
Stress does NOT HELP MS!
not proven*
Pathophysiology of MS:
- Demyelinating lesions→ Plaques
- sharply delineated lesions viewed on MRI
- Inflammation may result in Mass Effect (obj in skull that pushes brain)
- acute exacerb’s tx’d w/ steroids
More pathophys MS:
- IF oligodendrocytes survive→ remyelination may occur
- later stages→ if few remain, remyelination partial @ best
-
End Stage Patho:
- myelin replaced by fibrous scarring (gliosis)→ inhibits impulse transmission
*Types of MS:
4:
- Relapsing-Remitting (most common)
- aka Exacerbating-Remitting
- Relapsing-Progressive
- aka Exacerbating-Progressive
- Primary-Progressive
- aka Chronic-Progressive
- Secondary-Progressive
- the one that begins as Relapse-Remitting then Chronic-progressive
Types of MS:
Relapsing-Remitting
aka Exacerbating-Remitting
- Ep’s of rapid, abrupt deterioration w/ variable degrees of recovery over time
Types of MS:
Relapsing-Progressive
aka Exacerbating-Progressive
- Relapses w/ lg degrees of residual impairs
Types of MS:
Primary-Progressive
aka Chronic-Progressive
- Steady, progressive deterioration
- Pace of deterioration may be steady OR varied
Types of MS:
Secondary-Progressive
aka the one that BEGINS as relapse-remitting THEN becomes chronic (primary)-progressive
one that BEGINS as relapse-remitting THEN becomes chronic (primary)-progressive
- Sometimes Full recovery
- Sometimes Partial recovery
MS:
Definitive Dx requires WHAT?
- Requires clinical or para-clinical evidence of 2 or more spatially & temporally distinct lesions
- aka 2 diff areas @ 2 diff times***
MS Dx and MRI Findings:
- Lesions may NOT correlate w/ s/s
- Lesions may BE PRESENT in absence of s/s
- CSF via Lumbar Puncture
- elevated IgG→ immune system elevation
- Oligoclonal bands→ destruction of oligodendrocytes
Not Quite MS…
-
Clinically Isolated Syndrome (CIS)
- looks like exacerbation but happens 1 time
-
Radiologically Isolated Syndrome (RIS)
- Single time, has radiograph similar to MS, only one incident shown
Primary S/S MS:
- Presents in # of ways→ depends on loc. of demyelination
- Need useful SC vs. Cerebral (where plaques are)
Primary S/S MS:
Fatigue
- Single most common complaint in MS*
- Out of proportion to task causing it
- Present even if strength normal
- Fatigue→ Sx’s, HOW pt feels
- Fatigability→ Sign, change in motor perform
PRIMARY Fatigue
Caused by actual MS
- Lassitude→ sx of severe fatigue
- DEC conductivity→ reduced impulse propagation
SECONDARY Fatigue
Consequence
- infx
- spasticity
- ataxia
- weakness
- depression
- sleep deprivation
- polypharmacy (lots diff meds)
- decond.
Fatigue in PWMS and PT Implications
-
Ex. Type
- Diminished ability to tolerate lg amts of ex
- DO: Intermittent tx
-
Ex. Scheduling
- Schedule ex @ times of INC energy if they are willing to use that time to Ex.
PRIMARY s/s MS:
Sensory Changes
- Parasthesias→ partial sensation loss
- Dysesthesias→ abnorm sensation (burning)
MORE FREQ.
PRIMARY s/s MS:
Optic Neuritis
Optic neuritis
*NOTE: some have abrupt loss of vision 2-3d
COMMON
PRIMARY S/S MS:
Weakness
- PRIMARY→ from plaques (demyelination)
- SECONDARY→ disuse, deconditioning, disuse atrophy
PRIMARY S/S MS:
Weakness
A note about Flexibility
- MS does NOT directly cause prob w/ flex, but weakness and other sx cause probs
- W/out adequate flex→ person loses norm biomechanics for gait & balance
PRIMARY S/S MS:
Spasticity
*know the Mod Ashworth Scale!!
- UMN Syndrome common in PWMS
- worsens over time
-
IF spinal origin→ Intrathecal Baclofen pump
- NOT USEFUL IF CORTICAL LVL MS
PRIMARY S/S MS:
Heat Sensitivity
- Common
- Worse fatigue and weakness w/ elevation in body temp
- transitory→ NOT permanent
- Some benefit from cooling BEFORE ex.
Primary S/S MS:
Ataxia
- Due to plaques in cerebellum and DCML
- B/L
- Dysmetria, dysdiadochokinesia, tremor, vertigo
- CNS vs. PNS vertigo
Primary S/S MS:
Pain
- Spasms from hypERtonia
- Burning dysesthesias from plaques in thalamus or spinothalamic tract
- MSK pain from inapp. mvmt patterns → weakness, disuse atrophy
Primary S/S MS:
Psychiatric
- Euphoria→ late stages
- Depression
- Most common Cog. changes→ memory loss, impaired safety awareness***
Secondary S/S MS:
Weakness and Fatigue that occur due to MS causes what?
Series of 2* probs → VERY IMPORTANT TO PT’s!!!
2* S/S MS:
MSK issues
- Inapp mvmt patterns due to:
- Weakness
- Fatigue
- Spasticity
- Overuse syndromes/tendonitis 2* to spasticity
2* S/S MS:
Weakness
PRIMARY weakness cannot be affected by ex, 2* CAN
2* S/S MS:
Posture
- due to prolonged sitting
- Can benefit from pos’ing out of shortened pos.
- Poor posture leads to skin breakdown, contracture, resp. comps
2* S/S MS:
Balance Loss
- Combo of 1* and 2* effects
-
1*
- weakness, spasticity, ataxia, sensory loss, diminished motor control, visual loss, depression, fatigue
-
2*
- 2* weakness, contractures
Other 2* S/S MS:
- Osteoporosis
- Infections
Medical Mgmt MS:
One you should know
Ocrevus→ only FDA approved med to tx progressive types→ Slows progression
-
Steroids
- Tx of choice for acute exacerbation
- suppresses immune function
MS and Spasticity
Keep in mind..
Spasticity can be Useful!
- Eradication of spasticity can diminish underlying strength
MS and 2* Fatigue
- Improve fitness thru ex.
-
Energy Conservation tech’s combined w/ meds
- → Tx of choice for fatigue
Psychosocial Factors MS
Demanding dis. for both pt and caregiver→ unpredictable and hard to see
Rehab/PT Mgmt MS:
- No cure
- Tx focused on medically controlling current exacerbation
- Prevent 2* deficits
- EDUCATION→ teach pt and family as much as poss. about disease esp self mgmt of comps