MS

Question 1

What is MS also called whats maily happening?

Answer 1

disseminated sclerosis

chronic, inflammatory autoimmune disease of unknown etiology –> demyelination of the CNS –> neurologic dysfunctions

Question 2

Whats the men/women ration and age of onset in MS?

Answer 2

72% female, onset 21-40 years

Question 3

Symptoms of MS

Answer 3

numbness, tingling, weakness in extremetry, visual loss, color vision change, field defects, diplodia, dizziness, difficulty swallowing, bowel and bladder dysfunction, ataxia of gait

Question 4

What kind of diagnistic is used for MS?

Answer 4

MRI, oligoclonal banding, symptoms (normal MRI + symptoms do not exclude diagnosis, but without symptoms, no clear diagnosis)

Question 5

Name and describe the different disease courses in MS

Answer 5

RRMS: 1:2-3 (m/w)
SPMS: peak of disease 30 years, diagnosis after 3,4 years
PPMS: peak of disease 40-50 years, 1:1 (m/W), espaecially caucasians)

Question 6

McDonald MRI criteria evaluate ___ to diagnose MS

Answer 6

dissemination in space and time

Question 7

Name different treatment stages of MS

Answer 7

Escalated treatment (need when >=2 attacks per year, clinical progression and new MRI leasions or when basal treatment ist given but still >=1 attack per year)
Basal treatment
Boost treatment