MRSA Flashcards
clinda has good penetration
in tissue and bone.. not CNS
why clinda not rec for endocarditis or septic thrombophlebitits
bc bacteriostatic
When us D test
to see if clinda is RE
Dapto is bactericidal
lipopeptide disrupts cell membrane via calcium dependent bindign
Dapto FDA approved for…
R side endocarditis
cSSTI, bacteremia with SAUR
when dapto not be used
non hematogenous MRSA PNA bc activity is inhibited by surfactant
Dapto may have x resistance with
vanc
Adverse effects dapto
muscle pain and weakness
monitor CPK
Dapto preg cat
B
eosinophilic PNA assoc with
dapto
linezolid MOA
synthetic oxazolidinone and inhibits 50s
Linezolid MRSA FDA
nosocomial PNA, SSTI
Should give linezolid PO or IV ideally
PO ideally bc 100% bioavailable
Linezolid hematologically
toxicity with thrombocytopenia > anemia and neutropenia
also,
peripheral and optic neuropathy and lactic aidosis
linezolid serit…
seritonin syndrome
quinupristin-dalfopristin
2 streptogramin abx inhibit protein synthesis
FDA for cSSTI
salvage tx in setting of vanc failure
Rifampin
penetrates biofilms, RE quickly.
Telavancin
binds peptidoglycan precuruos and depolarizes th cell membrane
Telavancin is bactericidal against
MRSA, VISA, and VRSA
tigecycline is a derivative of
tetracycline
tigecylince has VD
high VD in tissues
low VD in serum
caustion treating for MRSA bacteremia
TMP-SMX
not FDA approved for MRSA
TMP-SMX electrolyte
increase potasisum
Vanc is slower
than cephalopsporins so not great for MSSA
