MRSA

Question 1

clinda has good penetration

Answer 1

in tissue and bone.. not CNS

Question 2

why clinda not rec for endocarditis or septic thrombophlebitits

Answer 2

bc bacteriostatic

Question 3

When us D test

Answer 3

to see if clinda is RE

Question 4

Dapto is bactericidal

Answer 4

lipopeptide disrupts cell membrane via calcium dependent bindign

Question 5

Dapto FDA approved for…

Answer 5

R side endocarditis

cSSTI, bacteremia with SAUR

Question 6

when dapto not be used

Answer 6

non hematogenous MRSA PNA bc activity is inhibited by surfactant

Question 7

Dapto may have x resistance with

Answer 7

vanc

Question 8

Adverse effects dapto

Answer 8

muscle pain and weakness

monitor CPK

Question 9

Dapto preg cat

Answer 9

B

Question 10

eosinophilic PNA assoc with

Answer 10

dapto

Question 11

linezolid MOA

Answer 11

synthetic oxazolidinone and inhibits 50s

Question 12

Linezolid MRSA FDA

Answer 12

nosocomial PNA, SSTI

Question 13

Should give linezolid PO or IV ideally

Answer 13

PO ideally bc 100% bioavailable

Question 14

Linezolid hematologically

Answer 14

toxicity with thrombocytopenia > anemia and neutropenia
also,
peripheral and optic neuropathy and lactic aidosis

Question 15

linezolid serit…

Answer 15

seritonin syndrome

Question 16

quinupristin-dalfopristin

Answer 16

2 streptogramin abx inhibit protein synthesis

FDA for cSSTI

salvage tx in setting of vanc failure

Question 17

Rifampin

Answer 17

penetrates biofilms, RE quickly.

Question 18

Telavancin

Answer 18

binds peptidoglycan precuruos and depolarizes th cell membrane

Question 19

Telavancin is bactericidal against

Answer 19

MRSA, VISA, and VRSA

Question 20

tigecycline is a derivative of

Answer 20

tetracycline

Question 21

tigecylince has VD

Answer 21

high VD in tissues
low VD in serum
caustion treating for MRSA bacteremia

Question 22

TMP-SMX

Answer 22

not FDA approved for MRSA

Question 23

TMP-SMX electrolyte

Answer 23

increase potasisum

Question 24

Vanc is slower

Answer 24

than cephalopsporins so not great for MSSA

Question 25

vanc tissue peneteration is variable

Answer 25

and has to do with how much inflammation there is

not great at bone, lungs epithelial lining fluid and csf