MRCPsych Mentor Flashcards
1
Q
Which antidepressants are available as IV?
A
Citalopram
Mirtazapine
Amitriptyline
Clomipramine
2
Q
Which antidepressants are available PR?
A
Amitriptyline Clomipramine Imipramine Doxepin Trazadone
3
Q
How can one take Amitriptyline?
A
PO
IV
IM
4
Q
Which antidepressant is available transdermally?
A
Selegiline
5
Q
Medications indicated for phobic & obsessional states
A
Clomipramine
6
Q
Adjunctive treatment of cataplexy associated with narcolepsy
A
Clomipramine
7
Q
Medications indicated for panic disorder and agoraphobia
A
Citalopram Escitalopram Sertraline Paroxetine Venlafaxine
8
Q
Medications indicated for soxial anxiety & phobias
A
Escitalopram Paroxetine Sertraline Moclobemide Venlafaxine
9
Q
Medications indicated for GAD
A
Escitalopram
Paroxetine
Duloxetine
Venlafaxine
10
Q
Medications indicated for OCD
A
Escitalopram Fluoxetine Fluvoxamine Paroxetine Sertraline
11
Q
Medications indicated for Bulimia
A
Fuloxetine
12
Q
Medications indicated for PTSD
A
Paroxetine
Sertraline
13
Q
How long should people >65 continue antidepressant medication for following remission?
A
2 years
14
Q
Which medication has is supported by evidence for use to treat hypersalivation secondary to clozapine?
A
Amisulpride
15
Q
Cut-off score indicating an ED in SCOFF?
A
2
16
Q
What was the first fully structured diagnostic interview for use by lay interviewers?
A
Diagnostic Interview Schedule
17
Q
Who created the Diagnostic Interview Schedule?
A
Robins et al. 1981
18
Q
Who launched the Epidemiological Catchment Programme?
A
National Institute of Mental Health
19
Q
What is the Composite International Diagnostic Interview?
A
Version of the DIS that uses ICD criteria
20
Q
Who created the Composite International Diagnostic Interview?
A
WHO
21
Q
What was the first large scale use of CIDI?
A
National Comorbidity Survery
22
Q
When did NCS take place?
A
1990s
23
Q
Was NCS an international survey?
A
No - national
24
Q
What did data from NCS and ECA suggest?
A
Number of people with MH problems outnumbered resources
25
What led to the development of the Word Mental Health CIDI?
The fact that ECA and NCS did not comment on severity of MH
26
What does WMH-CIDI take into account?
Severity of MH
Risk factors
Socio-demographics
Treatments
27
First line treatment of Tourettes?
Clonidine
28
Which antipsychotics show evidence for treating Tourettes?
Haloperidol
Pimozide
Risperidone
Olanzapine
29
When should valproate be considered with clozapine use?
Using high doses
Plasma levels >0.5mg/L
Patient has seizures
30
How many people develop fatal agranulocytosis form clozapine?
1 in 10,000
31
How many patients on clozapine develop neutropenia?
2.7%
32
Risk factors for neutropenia?
Race - 77% increase in risk for Afro-Caribbeans
Age (reduces)
Low baseline WCC
33
Is risk of neutropenia from clozapine related to dose?
No
34
Risk factors for clozapine induced agranulocytosis?
Age (increases)
| Ethnicity - 2.4x more likely in Asians than Caucasians
35
What does mutation of HPRT1 gene cause?
Lesch-Nyan syndrome
36
What refers to the true meaning behind a dream?
Latent content
37
Which factors are associated with poor prognosis of Anorexia?
```
Long duration of hospital care
Psychiatric co-morbidity
Adopted
One-parent household
Young mother
```
38
What is the primary metabolite of Paracetamol?
Benzoquinoneimine
39
How many databases are in the Cochrane Library?
6
40
What databases are in the Cochrane Library?
Cochrane Database of Systematic Reviews
Cochrane Central Register of Controlled Trials
Cochrane Methodology Register
Database of Abstracts of Reviews of Effects
Health Technology Assessment
NHS Economic Evaluation Database
41
Lifetime prevalence of use of cannabis
24%
42
Lifetime prevalence of use of amphetamines
7%
43
Lifetime prevalence of use of magic mushrooms
5%
44
Lifetime prevalence of use of ecstacy, cocaine or LSD
4%
45
Lifetime prevalence of use of transquilisers
3%
46
Lifetime prevalence of use of glue
1%
47
Lifetime prevalence of use of crack, heroin, anabolic steroids
<1%
48
Which antidepressants have a lower incidence os sexual dysfunction?
```
Bupropion
Mirtazapine
Moclobemide
Nefazadone
Reboxetine
```
49
What is transference based psychotherapy based on?
Otto Kernberg's theory of BPD
50
Which herbal remedy has evidence to support its effectiveness for depression?
Hypericum Perforatum
51
M:F ratio of reading disorder
3-4:1
52
M:F ratio of autism
4-5:1
53
M:F ratio of Aspergers
5:1
54
M:F ratio of Tourette's
2-5:1
55
M:F ratio of ADHD in children?
2:1
56
M:F ratio of ADHD in adults?
1.6:1
57
M:F ratio of depression
1:2
58
M:F ratio of Type 1 Bipolar
1:1
59
M:F ratio of Panic with agoraphobia
1:3
60
M:F ratio of Panic without agoraphobia
1:2
61
M:F ratio of GAD
1:2
62
M:F ratio of OCD
1:1
63
M:F ratio of specific phobia
1:2
64
M:F ratio of conversion disorder
1:2-10
65
M:F ratio of anorexia
1:9
66
M:F ratio of bulimia
1:9
67
M:F ratio of BPD
1:3
68
What does Suboxone contain?
Naloxone and Buprenorphine
69
In the AESOP study, the incidence of schizophrenia in Black-African groups was increased by what factor?
9
70
Drugs recommended for PTSD by NICE?
Paroxetine
Mirtazapine
Amitriptyline
Phenelzine
71
What did Bleuler divide schizophrenia into?
Type A
| Type B
72
What is indicative of Type A schizophrenia as per Bleuler?
Organic cause
73
Which type of schizophrenia is associated with the 4 A's?
Type A
74
What are the 4 A's of Bleuler's schizophrenia?
Autism
Ambivalence
Affect
Associations
75
Which sx does opiate misuse not lead to tolerance of?
Miosis
| Constipation
76
Maximum dose of clozapine
900mg/day
77
Maximum dose of haloperidol
20mg/day
78
Maximum dose of olanzapine
20mg/day
79
Maximum dose of quetiapine for schizophrenia
750mg/day
80
Maximum dose of quetiapine for bipolar
800mg/day
81
Maximum dose of risperidone
16mg/day
82
Maximum dose of amisulpride
1200mg/day
83
Maximum dose of aripiprazole
20mg/day
84
Maximum dose of flupentixol
400mg/week
85
Maximum dose of zuclopenthixol depot
600mg/week
86
Maximum dose of haloperidol depot
300mg every 4 weeks
87
Which psychiatric problem is maternal smoking most associated with?
ADHD
| Conduct Disorder
88
How many people with LD do not have an identifiable cause?
60%
89
Who divided schizophrenia into Type I and Type II?
Crow
90
Type I of schizophrenia
+ve sx
91
Type II of schizophrenia
-ve sx
92
What was suggested to cause Type I schizophrenia
Excess D2 receptors S
93
What was suggested to cause Type II schizophrenia?
Structural abnormality
94
Half-life (hours) of Diazepam
20-100
95
Half-life (hours) of clonazepam
18-50
96
Half-life (hours) of chlordiazepoxide
5-30
97
Half-life (hours) of nitrazepam
15-38
98
Half-life (hours) of temazepam
8-22
99
Half-life (hours) of lorazepam
10-20
100
Half-life (hours) of alprazolam
10-15
101
Half-life (hours) of oxzazepa
6-10
102
Half-life (hours) of zopiclone
5-6
103
Half-life (hours) of zolpidem
2
104
Half-life (hours) of zaleplon
2
105
Street names of Nephedrone
Meow Meow
M-Cat
White magic
106
Class of Mephedrone
Class B
107
What is Mephedrone structurally similar to?
Cathinone
108
Street names of Piperazines
BZP
| Silver Bullet
109
Class of Piperazine
Class B
110
Street names of GBL
Liquid ecstacy
| GBH
111
Class of GBL
Class C
112
What is GBL similar to?
Benzos
Baclofen
Alcohol
113
Street names of cannibinoids
Spice
| Black Mamba
114
Class of synthetic cannibinoids
B
115
Street name of Benzofuran compounds
Benzo fury
116
Class of Benzofuran compounds
B
117
Most common anxiety disorder in ECA?
Phobia
118
How does Heroin bind to opiate receptors?
G-coupled
119
What is mania a potu?
Pathological intoxication
120
At what age can a child copy a triangle?
5
121
At what age can a child hop on one foot?
4
122
At what age can a child copy a cross?
4
123
At what age can a child feed themself?
3
124
At what age can a child speak 2-3 word sentences
2
125
At what age can a child run
2
126
At what age can a child climb up and down the stairs alone
2
127
At what age can a child speak 10-20 words
18 months
128
At what age can a child walk without assistance
18 months
129
Which TCA is most associated with discontinuation sx?
Imipramine
130
Which Class C drug can one possess for personal use?
Anabolic steroids
131
Withdrawal features of opioids
```
Piloerection
Insomnia
Dilated Pupils
Yawning/sweating
Abdominal cramps
```
132
Withdrawal features of amphetamines and cocaine
Hypersomnia
Hyperphagia
Depression/irritability/agitation
Vivid Dreams
133
Withdrawal features of ecstasy
Depression/insomnia
| Depersonalisation/derealisation
134
Withdrawal features of cannabis
Insomnia
Reduced appetite
Irritability
135
Withdrawal features of hallucinogens
None
136
Withdrawal features of ketamine
None
137
Effects of opioids
Euphoria
Drowsiness
Pupil constriction
Respiratory depression
138
Effects of amphetamine and cocaine
```
Increased energy
Insomnia
Euphoria
Paranoia
Reduced appetite
```
139
Effects of MDMA/ecstasy
Increased energy & sweating
Jay Clenching
Euphoria
Increased response to touch
140
Effects of cannabis
Relaxation
Intensified sensory experience
Paranoia/anxiety
Injected conjunctivae
141
Effects of Hallucinogens
```
Perceptual changes
Pupil dilatation
Tachy/sweating
Palpitations
Tremors
Incoordination
```
142
Effects of ketamine
```
Euphoria
Dissociation
Ataxia
Hallucinations
Muscle rigidity
```
143
Street names of Ketamine
```
Vitamin K
Super K
Special K
K
Green
Donkey dust
```
144
Street names of hallucinogens
```
Trips
Tripper
Tab
Stars
Similies
Rainbows
Paper
```
145
Street names of cannabis
Grass
Mull
Cone
Chronic
146
Street names of ecstasy
```
XTC
E
Eccies
Pills
Adam Many
```
147
Street names of amphetamine
Ice
| Uppers
148
Street names of Cocaine
Snow
| Rock
149
Street names of opioids
```
Smack
Horse
Junk
Skag
Brown
Harry
H
```
150
What does Gudjonsson scale assess?
Suggestibility
151
Which gender develop conduct disorder at a younger age?
Males
152
What is each item of PANSS scored out of?
7
153
How many patients with Dementia are <65?
2%
154
What are the SCOFF questions?
Do you ever make yourself Sick because you feel uncomfortably full?
Do you ever worry that you have lost Control over how much you eat?
Have you recently lost more than One stone in a three month period?
Do you believe yourself to be Fat when others say you are too thin?
Would you say Food dominates you life?
155
What SCOFF score indicates likely ED?
2 or more
156
What are the cortical dementias?
Alzheimers
Picks
CJD
157
What does ADI-R stand for?
Autism Diagnostic Interview-Revised
158
What is ADI-R?
Semi-structured interview of caregivers of individuals with autism
159
What does ADOS-G stand for?
Autism Diagnostic Observation Schedule-Generic
160
What is ADOS-G?
Semistructured use of observational schedules
161
What does AAA stand for?
Adult Asperger Assessment
162
What does AAA consist of>
2 screening instruments; Autism-Spectrum Quotient & Empathy Quotient
1 clinician-conducted diagnostic questionnare; Adult Asperger Assessment
163
What does ASDI stand for
Asperger Syndrome Diagnostic INterview
164
What is ASDI
Investigator-based interview developed for assessment of Aspergers in adults and children.
165
What does ASDI consist of
Structured interview, 20 items divided into 6 behaviour areas
166
What does RAADS-R stand for
Ritvo Autism Asperger Diagnostic Scale Revised
167
What does RAADS-R consist of?
80-item self-rating scale for adults with averege/above average IQ
168
Best antipsychotics if hyperprolactinaema
Aripiprazole
Quetiapine
Olanzapine
169
After what age is enuresis diagnosed
5
170
Which model of the mind includes the id, ego and superego?
Structural
171
Prevalence of early onset schizophrenia
1 in 1000
172
What proportion of completed suicide occur in people >65?
20%
173
Risk of suicide following episode of DSH?
0.5-1.5%
174
What do the Maudsley guidelines advice re augmentation with clozapine?
```
Amisulpride
Aripiprazole
Haloperidol
Lamotrigine
Omega-3-triglycerides
Risperidone
Sulpiride
Topiramate
Ziprasidone
```
175
What drugs are specifically advised not to be augmented with clozapine?
Pimozide
| Olanzapine
176
Options if clozapine ineffective
```
Allopurinol + antipsychotic
Max dose amisulpride
Max dose aripiprazole
D-Alanine and D-Serine
ECT
High dose olanzapine
```
177
What stage of sleep do night terrors occur?
4
178
Duration of sx for diagnosis of schizophrenia?
1 months
179
Prevalence of OCD per 1000
19
180
Prevalence of avoidant PD per 1000
8
181
Prevalence of schizoid PD per 1000
8
182
Prevalence of paranoid PD per 1000
7
183
Prevalence of BPD per 1000
7
184
Prevalence of antisocial PD per 1000
6
185
Prevalence of dependent PD per 1000
1
186
Prevalence of schizotypal PD per 1000
1
187
% neutropenia risk for clozapine
3%
188
% agranulocytosis risk for clozapine
1%
189
Treatment for refractory depression
```
Add lithium
ECT
Add T3 (tri-iodothyronine)
Combined use of olanzapine and fluoxetine
Add quetiapine to an SSRI or SNRI
Add risperidone
Add aripiprazole
Bupropion and SSRI
SSRI and venlafaxine, mirtazapine, or mianserin
```
190
Prevalence of conduct disorder in 5-15 year olds
5%
191
Prevalence of anxiety and depression in 5-15 year olds
4%
192
Prevalence of hyperactive disorder in 5-15 year olds
1%
193
Prevalence of autism in 5-15 year olds
0.5%
194
Prevalence of tic disorder in 5-15 year olds
0.5%
195
Prevalence of ED in 5-15 year olds
0.5%
196
Is hypersalivation from clozapine dose related?
No
197
Which LD has cluttered speech?
Fragile X
198
Most common anxiety disorder in National Comorbidity survey
Specific phobia
199
Which medication is licensed for self-mutilating behaviour?
Lithium
200
What is asthenic PD?
Dependent PD
201
Which depot antipsychotic can be used as prophylaxis for mania?
Haloperidol
202
According to the ECA, which disorder was found to be most prevalent?
Substance misuse
203
Which SSRIs are licensed for treatment of OCD in young people
Sertraline
| Fluvoxamine
204
What is needed for diagnosis of HIV?
p24 antigen
205
First line investigation to help differentiate type of dementia
HMPAO SPECT
206
2nd line investigation for differentiating type of dementia
FDG PET
207
Who created IPT?
Sullivan
208
Which antipsychotics are recommended when avoiding TD?
Clozapine
| Quetiapine
209
Antipsychotics not associated with high prolactin?
```
Clozapine
Aripiprazole
Quetiapine
Olanzapine
Ziprasidone
```
210
Which family therapy concentrates on communication?
Strategic
