MRCPsych Mentor Flashcards
Which antidepressants are available as IV?
Citalopram
Mirtazapine
Amitriptyline
Clomipramine
Which antidepressants are available PR?
Amitriptyline Clomipramine Imipramine Doxepin Trazadone
How can one take Amitriptyline?
PO
IV
IM
Which antidepressant is available transdermally?
Selegiline
Medications indicated for phobic & obsessional states
Clomipramine
Adjunctive treatment of cataplexy associated with narcolepsy
Clomipramine
Medications indicated for panic disorder and agoraphobia
Citalopram Escitalopram Sertraline Paroxetine Venlafaxine
Medications indicated for soxial anxiety & phobias
Escitalopram Paroxetine Sertraline Moclobemide Venlafaxine
Medications indicated for GAD
Escitalopram
Paroxetine
Duloxetine
Venlafaxine
Medications indicated for OCD
Escitalopram Fluoxetine Fluvoxamine Paroxetine Sertraline
Medications indicated for Bulimia
Fuloxetine
Medications indicated for PTSD
Paroxetine
Sertraline
How long should people >65 continue antidepressant medication for following remission?
2 years
Which medication has is supported by evidence for use to treat hypersalivation secondary to clozapine?
Amisulpride
Cut-off score indicating an ED in SCOFF?
2
What was the first fully structured diagnostic interview for use by lay interviewers?
Diagnostic Interview Schedule
Who created the Diagnostic Interview Schedule?
Robins et al. 1981
Who launched the Epidemiological Catchment Programme?
National Institute of Mental Health
What is the Composite International Diagnostic Interview?
Version of the DIS that uses ICD criteria
Who created the Composite International Diagnostic Interview?
WHO
What was the first large scale use of CIDI?
National Comorbidity Survery
When did NCS take place?
1990s
Was NCS an international survey?
No - national
What did data from NCS and ECA suggest?
Number of people with MH problems outnumbered resources
What led to the development of the Word Mental Health CIDI?
The fact that ECA and NCS did not comment on severity of MH
What does WMH-CIDI take into account?
Severity of MH
Risk factors
Socio-demographics
Treatments
First line treatment of Tourettes?
Clonidine
Which antipsychotics show evidence for treating Tourettes?
Haloperidol
Pimozide
Risperidone
Olanzapine
When should valproate be considered with clozapine use?
Using high doses
Plasma levels >0.5mg/L
Patient has seizures
How many people develop fatal agranulocytosis form clozapine?
1 in 10,000
How many patients on clozapine develop neutropenia?
2.7%
Risk factors for neutropenia?
Race - 77% increase in risk for Afro-Caribbeans
Age (reduces)
Low baseline WCC
Is risk of neutropenia from clozapine related to dose?
No
Risk factors for clozapine induced agranulocytosis?
Age (increases)
Ethnicity - 2.4x more likely in Asians than Caucasians
What does mutation of HPRT1 gene cause?
Lesch-Nyan syndrome
What refers to the true meaning behind a dream?
Latent content
Which factors are associated with poor prognosis of Anorexia?
Long duration of hospital care Psychiatric co-morbidity Adopted One-parent household Young mother
What is the primary metabolite of Paracetamol?
Benzoquinoneimine
How many databases are in the Cochrane Library?
6
What databases are in the Cochrane Library?
Cochrane Database of Systematic Reviews
Cochrane Central Register of Controlled Trials
Cochrane Methodology Register
Database of Abstracts of Reviews of Effects
Health Technology Assessment
NHS Economic Evaluation Database
Lifetime prevalence of use of cannabis
24%
Lifetime prevalence of use of amphetamines
7%
Lifetime prevalence of use of magic mushrooms
5%
Lifetime prevalence of use of ecstacy, cocaine or LSD
4%
Lifetime prevalence of use of transquilisers
3%
Lifetime prevalence of use of glue
1%
Lifetime prevalence of use of crack, heroin, anabolic steroids
<1%
Which antidepressants have a lower incidence os sexual dysfunction?
Bupropion Mirtazapine Moclobemide Nefazadone Reboxetine
What is transference based psychotherapy based on?
Otto Kernberg’s theory of BPD
Which herbal remedy has evidence to support its effectiveness for depression?
Hypericum Perforatum
M:F ratio of reading disorder
3-4:1
M:F ratio of autism
4-5:1
M:F ratio of Aspergers
5:1
M:F ratio of Tourette’s
2-5:1
M:F ratio of ADHD in children?
2:1
M:F ratio of ADHD in adults?
1.6:1
M:F ratio of depression
1:2
M:F ratio of Type 1 Bipolar
1:1
M:F ratio of Panic with agoraphobia
1:3
M:F ratio of Panic without agoraphobia
1:2
M:F ratio of GAD
1:2
M:F ratio of OCD
1:1
M:F ratio of specific phobia
1:2
M:F ratio of conversion disorder
1:2-10
M:F ratio of anorexia
1:9
M:F ratio of bulimia
1:9
M:F ratio of BPD
1:3
What does Suboxone contain?
Naloxone and Buprenorphine
In the AESOP study, the incidence of schizophrenia in Black-African groups was increased by what factor?
9
Drugs recommended for PTSD by NICE?
Paroxetine
Mirtazapine
Amitriptyline
Phenelzine
What did Bleuler divide schizophrenia into?
Type A
Type B
What is indicative of Type A schizophrenia as per Bleuler?
Organic cause
Which type of schizophrenia is associated with the 4 A’s?
Type A
What are the 4 A’s of Bleuler’s schizophrenia?
Autism
Ambivalence
Affect
Associations
Which sx does opiate misuse not lead to tolerance of?
Miosis
Constipation
Maximum dose of clozapine
900mg/day
Maximum dose of haloperidol
20mg/day
Maximum dose of olanzapine
20mg/day
Maximum dose of quetiapine for schizophrenia
750mg/day
Maximum dose of quetiapine for bipolar
800mg/day
Maximum dose of risperidone
16mg/day
Maximum dose of amisulpride
1200mg/day
Maximum dose of aripiprazole
20mg/day
Maximum dose of flupentixol
400mg/week