MRCP Part 1

Question 1

Which molecule is the co-receptor for MHC class 1 ?

Answer 1

CD8 found in cytotoxic T cells

Question 2

Which cells predominantly produce interferon gamma

Answer 2

NK cells and helper T cells

Question 3

What is the role of interferon gamma?

Answer 3

Macrophage activation

Question 4

which cells produce interferon alpha

Answer 4

leucocytes

Question 5

which cells produce interferon beta

Answer 5

fibroblasts

Question 6

What is the cytogenetic abnormality in Down syndrome?

Answer 6

Non-disjunction

Question 7

What are the white spots present in the iris of patients with Down syndrome called?

Answer 7

Burchfield’s spots

Question 8

Which complement is responsible for recurrent bacterial infections

Answer 8

C3

Question 9

Which complement is responsible for immune complex disease such as SLE and Henoch-Schonlein Purpura?

Answer 9

C1q, C1r, C4, C2

Question 10

Which complement is responsible for N meningitidis infection?

Answer 10

C5-9 also activates the MAC

Question 11

What are the features of DiGeorge Syndrome?

Answer 11

CATCH 22
C - Cardiac abnormalities
A - Abnormal facies
T - Thymic aplasia
C - Cleft palate
H - Hypocalcaemia/ hypoparathyroidism
22 - Caused by chromosome 22 deletion

Question 12

Most appropriate method to demonstrate publication bias in a study is ?

Answer 12

Funnel plot

Question 13

Which Vitamin is given in homocystinuria?

Answer 13

Vitamin B6 Pyridoxine

Question 14

What is the usual outcome measure in A) Cohort study
b) case control study

Answer 14

A) Relative Risk
B) Odds ratio

Question 15

What is the difference between Cohort and CAse control study?

Answer 15

Both are observational
Cohort - Prospective
Case control - Retrospective

Question 16

What order are the layers of the skin?

Answer 16

Come, lets go sun bathe
Corneum
Lucidum
Granulosum
Spinosum
Basale(Germinatum)

Question 17

What molecule is responsible for binding and trafficking of proteins to lysosomes in the golgi apparatus?

Answer 17

Mannose 6 phosphate

Question 18

Which Ig is involved in the activation of B cells?

Answer 18

IgD

Question 19

what is the triad of congenital toxoplasmosis?

Answer 19

cerebral calcification
chorioretinitis
hydrocephalus

Question 20

what does heteroplasmy mean in mitochondrial diseases?

Answer 20

poor genotype phenotype correlation

Question 21

What are the enzyme inducers?

Answer 21

St Johns Funny Funny Mom Never Refuses Greasy Carbs and chronic alcohol - inducers (St Johns wort, Phenytoin, phenobarbital, Modafinil, Nevarapine, Rifampin Griseofulvin carbamazepine, chronic alcohol

Question 22

What is the MOA of Ketamine?

Answer 22

NMDA recpetor antagonist

Question 23

What is the medication given in SSRI toxicity with serotonin syndrome?

Answer 23

Cyproheptidine and Chlorpromazine

Question 24

What are the three ways barbiturates exerts their pharmacokinetics

Answer 24

Redistribution > metabolism, excretion

Question 25

The primary source of neuromuscular pathology in mercury poisoning is seen in

Answer 25

Dorsal root ganglia

Question 26

Mechanism of heparin induced thrombocytopenia ?

Answer 26

immune mediated - antibodies form against complexes of platelet factor 4 (PF4) and heparin

Question 27

MOA of amiloride

Answer 27

Selectively blocks the epithelium Na channel

Question 29

MOA of Carbimazole

Answer 29

Inhibition of iodination of Tyrosine

Question 30

MOA of propylthiouracil

Answer 30

Inhibition of 5 deiodinase

Question 31

Anti-convulsant which is associated with visual field effects/ behavioural changes

Answer 31

Vigabatrin

Question 32

Mechanism by which statins cause rhabdomyolysis

Answer 32

statins inhibit 3-hydroxy-3 methyl glutaryl co-A (HMGCoA) the rate limiting step in cholesterol synthesis

Question 33

MOA of Baclofen

Answer 33

GABAb Agonist

Question 34

What is the enzyme deficient in porphyra cutanea tarda ?
2. AIP
3. ALA dehydratase

Answer 34

1. uroporphyrinogen decarboxylase
2. porphobilinogen deaminase
3. Lead poisoning