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1
Q

rash around eyelids difficulty getting up and climbing (proximal muscle group) diagnosis and investigation?

A

Dermatomyositis
Raised CpK/CK

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2
Q

anemia, hepatospleenomegaly, raised WCC, basophils, raised platelets,

A

CML

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3
Q

Recurrent hypokalemia, muscle paralysis, family history present.
which channels involved?

A

periodic hypokalemic paralysis.
Calcium gated muscle group.

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4
Q

When to commence antiretroviral therapy in HIVposituve patient?

A

Immediately irrespective of CD4 count.

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5
Q

Patient with history of IBD, ulcer present on skin?
what is it? treatment?

A

pyoderma gangreosum, treatment topical tactolimius.

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6
Q

How does glucagon help hypotension and bradycardia?

A

Increase activity of cAMP

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7
Q

elderly, diabetic, alcohol, immunocompromised, meningitis not resolving with cefuroxime. Abx? and pathogen?

A

Listeria. ampicillin is treatment of choice.

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8
Q

Patient with sepsis, acidosis, high lactate low bicarbonate, what is the best treatment?

A

Isotonic Saline

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9
Q

Damage caused to ckin by UV light?

A

formation of pyrimidine dimers, apoptosis inflammatory response, resulting and skin thickening and tanning.

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10
Q

paroxysmal noctural hemaglobinuria.

A

Patient with recurrent VTE, anemia, low platelets. Urinalysis hemosiderin.

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11
Q

Moderate ileal reacection. 2 month hsitory of diarrjoea. Caue and treatment?

A

Bile acid malabsorption, colystyramine is the treatment of chooce in abscen of active infalmmation. SEHCAT test is the investigation of choice.

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11
Q

recuurent infections sinusitis, pneumonia.

A

Common variable immunodeficiency.

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12
Q

Congenital deafness, heart defect CNS effects in child, mother exposed to?

A

Isotretenoin. 1 month before, during and 1 month aftre.

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13
Q

balck pigment gallstones seen in?

A

sickle cell anemia, herditary spherocytosis, thallasemia and cirrhosis

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14
Q

factors precluding suregery in lung ca.

A

fev1 less than 1.5, malignant pleural effusion, contralateral lymph node involvement.

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15
Q

raised csf prtiein.
iliclonal antibodies

A

GBS l.p.
M>S

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16
Q

spending time across river fishing, present with jaundice spleenomegaly pruritis

A

leptospirosis

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17
Q
A
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18
Q

what to do if patient on first line tb medications shows progression of disease.

A

add 4th and 5th line

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19
Q

Known cancer patient with metastasis and anemia, what will be found in blood film?

A

Nucleated red cells.

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20
Q

most common side effect of cyclophosphamide?

A

anemia, neutropenia and thrombocytopenia.

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21
Q

patient developed blu grey discolouration after treatment of rosacea. drug causing this?

A

Minocycline.

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22
Q

down syndrome patient with not opened bowels abdomen distended sluggish bowel sounds.

A

Meckles diverticulum

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23
Q

antibiotic resposible for tendon rupture

A

levofloxacin

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24
cystic fibrosis
autosomal recessive
25
malgnant hypertension
iv sodium nitroprusside
26
athelete fast irregular palpitations on exertion and at rest, likley cause.
AF
27
lymphocytes which are larger in size, obvious nucleolus, projections present.
Hairy cell leukemia
28
Dose oh phenytoin is increased, when should the levels be checked again?
phenytoin average half life is 22 hour, recekecing in 2 weeks
29
Pregnant patient with low TSH and high T4. Treatment of choice?
Propylthiouracil, not to be used in late pregnancy.
30
Q fever pneumonia, contacted through?
Infected inhaled particles. Occupation is important.
31
32
Drugs that can flare up psoriasis are?
Beta blockers, lithium, antimalarials, NSAIDS.
33
female with mild depresssion buys over the counter medication, which drug is that?
St johns wart
34
what is the mode of action of bleomycin?
single strand scission of dna, leading to inhibition of cell division, growth, and dna synthesis in tumor cells.
35
Which antibiotic pre disposes to prolong qt and subsequent torsades?
Macrolides and quinolones. Calrithromycin, ciprofloxacin.
36
Small lesions then develop into christmas pattern, what is the diagnosis and treatmnent.
Pityriasis rosea. Reassurance, self resoving.
37
Investigation of choice for aspergilosis?
Galactomannan test., confirm by ELISA.
37
Young italian women with iron deficiency anaemia, nucleated red cells what is the diagnosis>?
thallassemia
38
mechanism of action of azathioprine.
inhibitor of purinen synthesis, inhibitis lymphocte prolifireation and infiltration.
39
band keratopathy is caused by?
calcium deposition.
40
burkitt lymphoma, gene associated>
c-myc
41
best diagnostic test for M.`S>?
intrthecal synthesis of igG
42
gluten sensitive enteropathy assaociated with deficiency of which immunoglobulin?
IgA
43
How metochlopramide causes hyper prolactin anemia?
Binds to D2 receptors on pituitary lactotropes. stimulates release of prolactin by anterior pituitary.
44
Side effects of donepezil are?
Nausea vomiting diarrhoea BRADYCARDIA rarely AV block
45
marfan syndrome occurs due to which gene?
defect in fibrillin 1 gene
46
Nodular solitary lesion on finger, occupation farmer, what is the diagnosis?
Orf
47
A small ventricluar septal defect, murmur heard?
Pan systolic murmur at left sternal edge.
48
Most common side effect of cuclosporin?
Tremor
49
Episooon potential is seen in which of the following ecg?
Right vetuculr dysplasia.
50
T scores?
osteopenia (-1 to -2.5) osteoporosis (<-2.5)
51
dapagliflozin, SGlt2 inhibitor mechanism of action?
Reduce glucose reabsorption, by increasing glucose renal excretion.
52
Chronic diarrhoea, weightloss, lymphadenopathy, intermittent rrthralgia. Diagnosis?
Whipples disease.
53
Patient with recuurent chest infections, bronchiactasis, abdominal bloating diarrhoea fouls smelling. What is the diagnosis?
cystic fibrosis.
54
Which blood abnormality is least likely to to be found in HIV patients?
Neutrophilia
55
carbimazole side effects:
nausea, rash, pruritus, arthralgia, alopecia, agranulocytosis, jaundice.
56
Drugs affecting INR.
Sodium valproate, erythromycin,
57
How to deifferntiatute between ATN and pre kidney disease.
low urine osmolality in ATN. (300)
58
long term dialysis is associated with which common complication?
Carpal Tunnel syndrome
59
drugs used for hepatitis C infection?
Daclatasvir and sofoabuvir.
60
HLA B51 is associated with which disease?
Bachet Disease.
61
speech difficulty, difficult forming words, which area of brain and blood vessel supply?
Broca’s Area, dominant frontal lobe, supplied by middle cerebral artery,
62
Conventional calcium blockers work on which type of calcium channel?
L type calcium channels.
63
plague psoriasis exacerbated by which drugs?
b blockers, antimalarials and lithium.
64
Wide, relatively fixed split s2?
RBBB with heart failure,
65
which one is not a live vaccine.
diphtheria
66
reverse splitting of second heart sound occurs in?
LBBB
67
Fall of which hormone is involved in shedding of endometrium during menstruation?
Progesterone
68
Juvenile myoclonic epilepsy, seizure, best medication to use?
Levertacitam
69
Which vessels are most sensitive to vasodilatory effect of nitrates?
Large Veins.
70
Posterior gastric ulcer, presenting with hemorrage, which artery is involoved?
Splenic artery.
71
bupropion in absolute contraindicated in which condition?
hx of generalised tonic clonic seizures.
72
which genetic syndrome is associated with alzheimers?
Down syndrome
73
Extensive port-wine bae us on one side of the face. which syndrome is associated?
Sturge-Weber syndrome.
74
Most aggressive lung C.A?
Small cell lung cancer. short duration of presenting symptoms. often presents with metastasis.
75
acute cold autoimmune haemolytic anaemia in young patients cause?
Mycoplasma pneumonia infection.
76

mrcp (1 decks)

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