Movement DOs Flashcards
MCC of action tremors in adults
Essential tremors
Meds that can trigger essential tremors
- Caffeine
- ETOH Withdrawal
- Sympathomimetics
- Antipsychotics
- Theophyline
- Metoclopramide
- Lithium
- Levothyroxine
- TCAs
- Valproic Acid
- Reserpine
Relatioship b/w alcohol and essential tremors?
alcohol helps tremors!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
What part of body is most likely to shake with essential tremors?
HANDS
Essential tremors are very common with _____ Dz
Wilson’s
Check LFT, Serum Ceruloplasmin, Cu (copper), 24Hr urine copper piss
1st line Tx for essential tremors
Propanolol or Primidone
Get imaging for suspected essential tremors if <___yo
40
Essential tremors pathophys occurs in what part of the brain?
Thalamus
Huntington Dz = defect on chromosome ___ -> CAG repeats -> too much glutamine
4p
MC Early stage SS for huntington Dz
DEPRESSION
Huntington Dz WU
- genetic counseling/testing
- CT/MRI -> cerebral and caudate nucleus atrophy (large lateral ventricles)
Huntington Dz Tx for chorea if depressed
Risperidone or Haloperidol
Avoid VMAT2 Inhibitors (Tetrabenazine & Deutrabenazine) bc they will make the depression worse :(
MCC of Death in those with Huntington Dz
Sepsis
100% mortality???? damn
1 ET of parkinson
idiopathic
Genetically inherited parkinsons put you at higher risk for ______
lew body dementia
is parkinsons high or low dopamine?
LOW
ther is progressive degeration of dopamine producing neurons in the substantia nigra pars compacta
when you tap over the nasal bridge of someone with parkinsons, do you expect them to blink more or less than a normal person?
LESS
DECR EYE BLINK RATE
MAO-B Inhibitors are really only effective in which group of patients with parkinsons?
Rasagiline, Safinamide
YOUNGER Pts
Does levodopa or Carbidopa cross the blood brain barrier?
LEVODOPA
Mainstay pharm Tx for parkinsons
Dopaminergics -> Levodopa (dopamine precursor)
Stopping levodopa abruptly may cause
Akinetic crisis -> FROZEN RIGIDITY
SS of dementia with lewy bodies
flunctuations in attention and alertness
visual hallucinations
REM sleep DOS (kicking, fighting) - SHILOH
