Mouse strains and characteristics Flashcards
High intermale aggression
BALB/c and Swiss- origin stocks and strains
Mutation causing blindness in C3H/HE mice
rd1 mutation (Pde6b^rd1)
Most common B6 neoplasms
Lymphoma, hemangiosarcoma, pituitary adenoma
Pugilistic adult males
BALB/c mice
Resistant to amyloidosis
BALB/c
Most common BALB/c neoplasms
lung adenomas, lymphoma, Harderian gland tumors, adrenal adenomas, myoepitheliomas of exocrine glands
Develop alopecia areata as they age
C3H/He
Common C3H/He neoplasms
Mammary neoplasia due to endogenous MMTV, hepatocellular tumors
Most frequent source of embryonic (ES) stem cells
129 mice
Develop testicular teratomas (embryonal carcinomas)
129/Sv
Common 129 neoplasms
lung tumors, Harderian gland tumors, ovarian tumors, hemangiosarcomas
Mutation causing FVB/N blindness
rd1 homozygosity (Pde6b^rd1)
Common neoplasms of FVB/N
tumors of lung, pituitary, Harderian gland, liver, lymphoma, pheochromocytomas
Outbred Swiss health issues
retinal degeneration, amyloidosis
Common neoplasms of outbred Swiss
lymphomas, pulmonary adenomas, liver tumors, pituitary adenomas, hemangiomas/sarcomas