Most likely to cure cancer. Flashcards
Thiotepa
Alkylator: works everywhere in the cell cycle, cross-linking guanine residues and breaking the DNA strand.
Busulfan
Alkylator: works everywhere in the cell cycle, cross-linking guanine residues and breaking the DNA strand.
Tesmozolomide
Alkylator: works everywhere in the cell cycle, cross-linking guanine residues and breaking the DNA strand.
Platinum Drugs
Alkylator: works everywhere in the cell cycle, covalently binding all bases and breaking the DNA strand.
Carboplatin
Alkylator: works everywhere in the cell cycle, covalently binding all bases and breaking the DNA strand.
PLATINUM DRUG
Cysplatin
Alkylator: works everywhere in the cell cycle, covalently binding all bases and breaking the DNA strand.
PLATINUM DRUG
Ototoxic, nephrotoxic, nauseating.
Doxorubacin
Antibiotic: non-specific in cell cycle. Intercalate btwn base pairs, inhibit topoisomerase II, generate free radicles, and disrupt membranes.
The free radicals damage cardiac muscle, and those don’t grow back. :(
Daunorubicin
Antibiotic: non-specific in cell cycle. Intercalate btwn base pairs, inhibit topoisomerase II, generate free radicles, and disrupt membranes.
The free radicles damage cardiac muscles, and those don’t grow back :(
Idarubicin
Antibiotic: non-specific in cell cycle. Intercalate btwn base pairs, inhibit topoisomerase II, generate free radicles, and disrupt membranes.
The free radicles damage cardiac muscles, and those don’t grow back. :(
Belomycin
Antibiotic: non-specific in cell cycle. Intercalate btwn base pairs, inhibit topoisomerase II, generate free radicles, and disrupt membranes.
PULMONARY FIBROSIS
Methotrexate
Antimetabolite
Inhibits dihydrofolate, so you can’t make folate, which is a purine/pyrimidine precursor.
Tumors w/ a mutation in the MTHFR gene have less folate producing options and are more sensitive to methotrexate.
6-mercaptopurine
antimetabolite
purine analog
thioguanine
antimetabolite
purine analog
Cytarabine
antimetabolite
pyrimidine analog
causes flu-like symptoms and chemical conjunctivitis
(co-prescribe w/ steroid eye drops)
Vinka alkaloids
Mitotic inhibitors.
Disrupt the polymerization of tubulin.
Vincristine
Mitotic inhibitors.
Disrupt the polymerization of tubulin.
VINKA ALKALOID
Vinblastine
Mitotic inhibitors.
Disrupt the polymerization of tubulin.
VINKA ALKALOID
Vinorelbine
Mitotic inhibitors.
Disrupt the polymerization of tubulin.
VINKA ALKALOID
Taxanes
Mitotic inhibitors.
Disrupt the DEpolymerization of tubulin.
Irnotecan
Topoisomerase inhibitor: prevent re-annealing of DNA and stop DNA synthesis.
Can cause diahrea.
Etoposide
Topoisomerase inhibitor: prevent re-annealing of DNA and stop DNA synthesis.
Can cause allergic reactions.
Leuprolide
Hormone.
GNRH agonist, occupying the GNRH receptor in the pituitary and inhibiting the release of FSH and LH.
Tamoxifen
Hormone.
Estrogen antagonist: binds the breast tissue estrogen receptor and decreases its expression over time.
Nitrogen Mustards
Alkylators: work everywhere in the cell cycle, cross-linking guanine residues and breaking the DNA strand.
Cause hemorrhagic cystitis b/c of metabolite buildup. The rescue drug MESNA binds that metabolite.
