Most likely to cure cancer.

Question 1

Thiotepa

Answer 1

Alkylator: works everywhere in the cell cycle, cross-linking guanine residues and breaking the DNA strand.

Question 2

Busulfan

Answer 2

Alkylator: works everywhere in the cell cycle, cross-linking guanine residues and breaking the DNA strand.

Question 3

Tesmozolomide

Answer 3

Alkylator: works everywhere in the cell cycle, cross-linking guanine residues and breaking the DNA strand.

Question 4

Platinum Drugs

Answer 4

Alkylator: works everywhere in the cell cycle, covalently binding all bases and breaking the DNA strand.

Question 5

Carboplatin

Answer 5

Alkylator: works everywhere in the cell cycle, covalently binding all bases and breaking the DNA strand.

PLATINUM DRUG

Question 6

Cysplatin

Answer 6

Alkylator: works everywhere in the cell cycle, covalently binding all bases and breaking the DNA strand.

PLATINUM DRUG
Ototoxic, nephrotoxic, nauseating.

Question 7

Doxorubacin

Answer 7

Antibiotic: non-specific in cell cycle. Intercalate btwn base pairs, inhibit topoisomerase II, generate free radicles, and disrupt membranes.

The free radicals damage cardiac muscle, and those don’t grow back. :(

Question 8

Daunorubicin

Answer 8

Antibiotic: non-specific in cell cycle. Intercalate btwn base pairs, inhibit topoisomerase II, generate free radicles, and disrupt membranes.

The free radicles damage cardiac muscles, and those don’t grow back :(

Question 9

Idarubicin

Answer 9

Antibiotic: non-specific in cell cycle. Intercalate btwn base pairs, inhibit topoisomerase II, generate free radicles, and disrupt membranes.

The free radicles damage cardiac muscles, and those don’t grow back. :(

Question 10

Belomycin

Answer 10

Antibiotic: non-specific in cell cycle. Intercalate btwn base pairs, inhibit topoisomerase II, generate free radicles, and disrupt membranes.

PULMONARY FIBROSIS

Question 11

Methotrexate

Answer 11

Antimetabolite

Inhibits dihydrofolate, so you can’t make folate, which is a purine/pyrimidine precursor.

Tumors w/ a mutation in the MTHFR gene have less folate producing options and are more sensitive to methotrexate.

Question 12

6-mercaptopurine

Answer 12

antimetabolite

purine analog

Question 13

thioguanine

Answer 13

antimetabolite

purine analog

Question 14

Cytarabine

Answer 14

antimetabolite
pyrimidine analog

causes flu-like symptoms and chemical conjunctivitis
(co-prescribe w/ steroid eye drops)

Question 15

Vinka alkaloids

Answer 15

Mitotic inhibitors.

Disrupt the polymerization of tubulin.

Question 16

Vincristine

Answer 16

Mitotic inhibitors.
Disrupt the polymerization of tubulin.

VINKA ALKALOID

Question 17

Vinblastine

Answer 17

Mitotic inhibitors.
Disrupt the polymerization of tubulin.

VINKA ALKALOID

Question 18

Vinorelbine

Answer 18

Mitotic inhibitors.
Disrupt the polymerization of tubulin.

VINKA ALKALOID

Question 19

Taxanes

Answer 19

Mitotic inhibitors.

Disrupt the DEpolymerization of tubulin.

Question 20

Irnotecan

Answer 20

Topoisomerase inhibitor: prevent re-annealing of DNA and stop DNA synthesis.

Can cause diahrea.

Question 21

Etoposide

Answer 21

Topoisomerase inhibitor: prevent re-annealing of DNA and stop DNA synthesis.

Can cause allergic reactions.

Question 22

Leuprolide

Answer 22

Hormone.

GNRH agonist, occupying the GNRH receptor in the pituitary and inhibiting the release of FSH and LH.

Question 23

Tamoxifen

Answer 23

Hormone.

Estrogen antagonist: binds the breast tissue estrogen receptor and decreases its expression over time.

Question 24

Nitrogen Mustards

Answer 24

Alkylators: work everywhere in the cell cycle, cross-linking guanine residues and breaking the DNA strand.

Cause hemorrhagic cystitis b/c of metabolite buildup. The rescue drug MESNA binds that metabolite.