Most Common Flashcards

1
Q

Most commonly used risk factor for determining screening and prevention recommendations

A

Age

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2
Q

Most common adverse event in health care, based in the Harvard Medical Practice Study

A

Adverse drug events (19%)

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3
Q

Most common pharmacological intervention for anticipatory nausea

A

Benzodiazepine, such as lorazepam

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4
Q

Most common symptom that brings a patient to a physician’s attention

A

Pain

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5
Q

Most commonly used analgesics

A

COX inhibitors

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6
Q

Most common error made by physicians in managing severe pain with opioids

A

To prescribe an inadequate dose

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7
Q

Most common emotional disturbance in patients with chronic pain

A

Depression

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8
Q

Most common diagnoses in patients in the ED who present with chest discomfort

A

Gastrointestinal causes

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9
Q

Most common cause of nontraumatic chest discomfort

A

Gastrointestinal disorders

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10
Q

Most common cause of unresponsiveness to treatment of chronic daily headache

A

Use of a preventive when analgesics continue to be used regularly

(It must be emphasized that preventives often do not work in the presence of analgesic overuse.)

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11
Q

Most common cause of headache due to persistent low CSF volume

A

CSF leak following lumbar puncture

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12
Q

Most common cause of disability in individuals <45 years of age

A

Back symptoms

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13
Q

Most common neurologic symptom in patients with systemic cancer and is the presenting symptom in 20%

A

Back pain

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14
Q

Most common cause of nontraumatic vertebral body fractures

A

Postmenopausal or senile osteoporosis

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15
Q

Most common cause of persistent low back pain in adolescents

A

Spondylolosis

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16
Q

Most common cause of arachnoiditis in developing countries

A

Prior spine infection

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17
Q

Most common cause of arachnoiditis in developed countries

A

Multiple lumbar spine surgeries

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18
Q

Roots most commonly affected in cervical radiculopathies

A

C6 and C7

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19
Q

Extraordinarily high fevers (>41.5C) most commonly occurs in patients with

A

Central nervous system hemorrhages

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20
Q

Most common type of skin eruption

A

Centrally distributed rashes, in which lesions are primarily truncal

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21
Q

Most common drug reaction manifestation

A

Exanthematous drug-induced eruptions

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22
Q

Most common age group affected by exanthem subitum (roseola), which is caused by human herpesvirus 6

A

Children <3 years of age

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23
Q

Most common cause of hand-foot-and-mouth disease

A

Coxsackievirus A16 or Enterovirus 71

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24
Q

Most common age group affected by erythema infectiosum (fifth disease), which is caused by human parvovirus B19

A

Children 3-12 years old

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25
Q

Most common age group and sex affected by SLE

A

Middle-aged women

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26
Q

Most common age group affected by scarlet fever (second disease), which is caused by Group A Streptococcus

A

Children 2-10 years old

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27
Q

Most common season of varicella (chickenpox)

A

Late winter and spring

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28
Q

Most commonly affected body areas in ecthyma gangrenosum, which is caused by P. aeruginosa

A

Axillary, groin, perianal regions

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29
Q

Most commonly affected body areas of the purpuric eruptions in acute meningococcemia, which is caused by N. meningitidis

A

Trunk and extremities

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30
Q

Most common population affected by acute meningococcemia

A

Children, individuals with asplenia, or terminal complement component deficiency (C5-C8)

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31
Q

Most common diagnosis of FUO among the neoplasms

A

Malignant lymphoma

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32
Q

Most common infectious disease associated with FUO in elderly patients

A

Tuberculosis

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33
Q

Most common cause of syncope in population-based studies

A

Neurally mediated syncope

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34
Q

Most common cause of acquired QT interval prolongation

A

Drugs

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35
Q

Most commonly used procedure for posterior canal BPPV

A

Epley maneuver

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36
Q

Most common medication that causes bilateral vestibular hypofunction

A

Gentamicin, or other aminoglycoside antibiotics

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37
Q

Disease entity most commonly observed in veterans of the 1991 Gulf war conflict

A

Chronic multisymptom illness, also known as Gulf-war syndrome

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38
Q

Most common cause of acute paraparesis

A

Intraspinal lesion

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39
Q

Most common body part where the ulnar nerve is injured which leads to the characteristic dysesthesia that is restricted to the 5th digit and the adjacent 1/2 of the 4th finger on one hand

A

Elbow

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40
Q

Most common cause of frontal gait disorder

A

Vascular disease, particularly subcortical small-vessel disease in the deep frontal white matter and centrum ovale

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41
Q

The cognitive function most commonly lost in dementia

A

Episodic memory, the ability to recall events specific in time and place

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42
Q

Most common cause of dementia in Western countries

A

Alzheimer’s disease

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43
Q

Three most common potentially reversible causes of dementia

A

1) Depression
2) Normal pressure hydrocephalus (NPH)
3) Alcohol dependence

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44
Q

Single most common finding in aphasic patients

A

Deficit of naming (anomia)

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45
Q

Lesion site most commonly associated with Wernicke’s aphasia caused by CVAs

A

Posterior portion of the language network

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46
Q

Most common etiology of Wernicke’s aphasia

A

Embolus to the inferior division or angular branches of the middle cerebral artery (MCA)

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47
Q

Single most common language disturbance seen in head trauma, metabolic encephalopathy, and Alzheimer’s disease

A

Anomic aphasia

(Articulation, comprehension, and repetition are intact, but confrontation naming, word finding, and spelling are impaired.)

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48
Q

Most common causes of pure word deafness (patient reacts to speech as if it were in an alien tongue that cannot be deciphered; have no difficulty understanding written language and can express themselves well in spoken or written language)

A

Bilateral or left-sided MCA strokes affecting the superior temporal gyrus

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49
Q

Most common subtype of primary progressive aphasia (PPA) that is associated with the pathology of Alzheimer’s disease

A

Logopenic PPA

(Preserved syntax and comprehension but frequent and severe word-finding causes, anomia, circumlocutions, and simplifications during spontaneous speech.)

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50
Q

Most common cause of progressive memory impairments in the elderly

A

Alzheimer’s disease

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51
Q

Single most common behavioral profile associated with a variety of bilateral multifocal brain diseases, including metabolic encephalopathy, multiple sclerosis, and vitamin B12 deficiency

A

Frontal lobe syndrome, usually of the abulic form (p166)

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52
Q

Probably the most common cause of excessive daytime sleepiness

A

Insufficient sleep

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53
Q

Most commonly prescribed alternatives to benzodiazepine receptor agonists due to their lack of abuse potential and lower cost

A

Heterocyclic antidepressants (trazodone, amitriptyline, and doxepin) (p174)

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54
Q

Most common age group that experiences sleepwalking

A

Children and adolescents, when deep NREM sleep is most abundant (p174)

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55
Q

Most common cause of a red, irritated eye

A

Conjunctivitis (p182)

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56
Q

Most common viral etiology of conjunctivitis

A

Adenovirus infection (p182)

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57
Q

Most common source of emboli that cause amaurosis fugax

A

Atherosclerotic plaque in the carotid artery or aorta (p183)

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58
Q

Most common form of anterior ischemic optic neuropathy (AION)

A

Nonarteritic form (p184)

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59
Q

Most common cause of blindness in the world

A

Cataract (p187)

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60
Q

Most common age group affected by epiretinal membrane

A

Patients aged >50 years

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61
Q

Most common primary tumor of the eye

A

Melanoma

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62
Q

Most common cause of internuclear ophthalmoplegia

A

Multiple sclerosis

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63
Q

Most common etiology of vertical gaze

A

Distal basilar artery ischemia

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64
Q

Most common form of jerk nystagmus

A

Gaze-evoked nystagmus

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65
Q

Three most common identifiable cause of long-lasting or permanent smell loss seen in the clinic (in order of frequency)

A

Severe upper respiratory tract infections
Head trauma
Chronic rhinosinusitis

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66
Q

Most common cause of sensorineural hearing loss in adults

A

Presbycusis (age-associated hearing loss)

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67
Q

Most common pathogens in community-acquired acute rhinosinusitis

A

S. pneumoniae and nontypable Haemophilus influenzae

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68
Q

Most common sinus affected in rhinosinusitis

A

Maxillary sinus

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69
Q

Most common pathogens in perichondritis

A

P. aeruginosa and S. aureus

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70
Q

Most common cause of chronic otitis externa

A

Persistent drainage from a chronic middle-ear infection which causes repeated local irritation

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71
Q

Most common pathogen in invasive otitis externa

A

P. aeruginosa

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72
Q

Most common presenting symptom of oropharyngeal infections

A

Sore throat

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73
Q

Most common cause of acute pharyngitis

A

Rhinoviruses (~20%)

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74
Q

Most common teeth that causes Ludwig angina (a rapidly progressive, potentially fulminant form of cellulitis that involves the bilateral sublingual and submandibular spaces and that typically originates from an infected ore recently extracted tooth)

A

Lower 2nd or 3rd molar

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75
Q

Most common cause of death in Ludwig angina

A

Asphyxiation

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76
Q

Most common cause of epiglottitis in adults and (more recently) in children

A

Group A Streptococcus

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77
Q

Infections of the retropharyngeal space is usually a consequence of extension from another site of infection, most commonly _____

A

Acute pharyngitis

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78
Q

Most common pathogens in retropharyngeal space infection

A

Group A beta-hemolytic streptococci and S. aureus

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79
Q

Most common developmental oral problem

A

Malocclusion

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80
Q

Most common oral mucosal lesion

A

Ulceration

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81
Q

Most common nondental source of oral pain

A

Myofascial pain referred from muscles of mastication

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82
Q

Most common part of oral mucosa that is involved in Kaposi’s sarcoma

A

Palate

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83
Q

Most common etiology of xerostomia

A

Medication, especially drugs with anticholinergic properties

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84
Q

Type of adult patients most commonly affected by acute bacterial parotitis

A

Postoperative, dehydrated, and debilitated patients

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85
Q

Most common pathogens in acute bacterial parotitis

A

S. aureus and anaerobic bacteria

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86
Q

Part of the respiratory tree that is the most common source of hemoptysis

A

Bronchi or medium sized airways

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87
Q

Most common cause of hemoptysis worldwide

A

Tuberculosis

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88
Q

Most common of respiratory hypoxia

A

Ventilation-perfusion mismatch resulting from perfusion of poorly ventilated alveoli

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89
Q

Probably the most common cause of peripheral cyanosis

A

Normal vasoconstriction resulting from exposure to cold air or water

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90
Q

Most common cause of a midsystolic murmur in an adult

A

Aortic stenosis

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91
Q

Most common cause of left-to-right intracardiac shunt in adults

A

Ostium secundum ASD

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92
Q

Most common cause of mitral stenosis

A

Rheumatic fever

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93
Q

Most common setting of aphagia (inability to swallow)

A

Food bolus or foreign body impaction

Aphagia typically denotes complete esophageal obstruction

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94
Q

Most common cause of oropharyngeal dysphagia

A

Functional deficits caused by neurologic disorders

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95
Q

Most common etiology of gastroparesis

A

Idiopathic

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96
Q

Most common surgeries that lead to postoperative emesis

A

Abdominal and orthopedic surgery

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97
Q

Most common causes of indigestion (2)

A

Gastroesophageal reflux and functional dyspepsia

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98
Q

Most common causes of ulcers (2)

A

H. pylori infection and NSAID use

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99
Q

Most common cause of infectious diarrhea in institutionalized patients

A

C. difficile

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100
Q

Probably the most common noninfectious causes of acute diarrhea

A

Side effects from medications

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101
Q

Most common secretory causes of chronic diarrhea

A

Side effects from regular ingestion of drugs and toxins

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102
Q

Most common cause of intraluminal maldigestion

A

Pancreatic exocrine insufficiency (occurs when >90% of pancreatic secretory function is lost)

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103
Q

Most common cause of mucosal malabsorption

A

Celiac disease

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104
Q

2 most common causes of osmotic diarrhea

A

Lactose intolerance and magnesium ingestion

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105
Q

Most common cause of outlet obstruction in constipation

A

Failure of the puborectalis muscle to relax

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106
Q

Most common gastrointestinal condition leading to hospitalization

A

Gastrointestinal bleeding

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107
Q

Most common cause of UGIB

A

Peptic ulcers

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108
Q

Most common cause of LGIB in adults, if hemorrhoids and anal fissures are excluded

A

Diverticulosis

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109
Q

Most common location of varices that lead to LGIB

A

Rectal

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110
Q

Most common colonic causes of significant GIB in children and adolescents

A

Inflammatory bowel disease and juvenile polyps

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111
Q

Most common cause of significant small-intestinal GIB in children

A

Meckel’s diverticulum

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112
Q

Probably the most common cause of LGIB

A

Hemorrhoids

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113
Q

Drugs most commonly associated with cholestasis

A

Anabolic and contraceptive steroids

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114
Q

Malignancy most commonly associated with primary sclerosing cholangitis (PSC)

A

Cholangiocarcinoma

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115
Q

Most common cause of extrahepatic cholestasis

A

Choledocholithiasis

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116
Q

Most common pathogens in spontaneous bacterial peritonitis

A

E. coli and Klebsiella

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117
Q

Most common site involved and generally the one with the most severe pain in interstitial cystitis/bladder pain syndrome

A

Suprapubic area

118
Q

Most common cause of solute diuresis

A

Poorly controlled diabetes mellitus with glucosuria

119
Q

Most common malignancy associated with SIAD

A

Small-cell lung carcinoma

120
Q

Most common type of drug that causes SIAD

A

Selective serotonin reuptake inhibitors (SSRIs)

121
Q

Most common gastrointestinal cause of hypernatremia

A

Diarrhea

122
Q

Most common beta agonist used in the acute management of hyperkalemia

A

Albuterol

123
Q

Most common mutation in familial hypocalciuric hypercalcemia (FHH)

A

Calcium sensor receptor

124
Q

Most common cause of chronic hypercalcemia

A

Primary hyperparathyroidism

125
Q

Most common etiologies of hypocalcemia

A

Impaired PTH production and impaired vitamin D production

126
Q

Most common cause of hypoparathyroidism in adults

A

Inadvertent damage to all four glands during thyroid or parathyroid gland surgery

127
Q

Most common acid-base disturbance in critically ill patients and, when severe, portends a poor prognosis

A

Chronic respiratory alkalosis

128
Q

Most common cause of drug-induced respiratory alkalosis

A

Salicylates

129
Q

Most common type of melanoma

A

Superficial spreading melanoma

130
Q

Most common type of irritant contact dermatitis

A

Chronic low-grade irritant dermatitis

131
Q

Most common area involved in chronic low-grade irritant dermatitis

A

Hands

132
Q

Most common cause of allergic contact dermatitis

A

Exposures to plants, especially to members of the family Anacardiaceae, including the genus Toxicodendron

133
Q

Most common population involved in nummular eczema

A

Middle aged men

134
Q

Most common location of seborrheic dermatitis

A

Scalp

135
Q

Most common variety of psoriasis

A

Plaque-type

136
Q

Most common dermatophyte infection

A

Tinea pedis

137
Q

Most common variant affected in tinea unguium or onychomycosis

A

Distal-lateral variant

138
Q

Most commonly prescribed drug for cutaneous candidiasis

A

Oral fluconazole

139
Q

Extragenital skin involvement in squamous cell carcinomas associated with HPV infections is most commonly seen in this kind of patients

A

Patients immunosuppressed after organ transplantation

140
Q

Most common location for acne

A

Face

141
Q

Most common malignancy associated with erythroderma

A

Cutaneous T cell lymphoma

142
Q

Most common pathogen in Tinea capitis

A

Trichophyton tonsurans

143
Q

Most common pustular dermatoses

A

Acneiform eruptions and folliculitis

144
Q

Most common forms of hypopigmentation are due to mutations in the

A

Tyrosinase gene (type I) or the P gene (type II)

145
Q

Most common location of pigment loss in Vogt-Koyanagi-Harada syndrome

A

Face and scalp

146
Q

Most common autoimmune diseases associated with diffuse hyperpigmentation

A

Biliary cirrhosis and systemic sclerosis

147
Q

Most common malignancy associated with acanthosis nigricans

A

Gastrointestinal malignancy

148
Q

Most common form of porphyria with cutaneous findings

A

Porphyria cutanea tarda (PCT)

149
Q

Most common setting of the prototypic scarlatiniform eruption seen in scarlet fever, due to an erythrogenic toxin produced by group A beta-hemolytic streptococci

A

Pharyngitis

150
Q

2 most common forms of cutaneous eruption in Kawasaki disease

A

Morbilliform and scarlatiniform

151
Q

Elevated calcium phosphate products which can lead to metastatic calcinosis cutis are most commonly due to

A

Secondary hypoerparathyroidism in the setting of renal failure

152
Q

Osteoma cutis, in the form of small papules, most commonly occurs on the face of individuals with a history of _____

A

Acne vulgaris

153
Q

Most common forms of xanthomas and are associated with hypertriglyceridemia

A

Eruptive xanthoma

154
Q

Most common setting for eruptive xanthomas

A

Uncontrolled diabetes mellitus

155
Q

Most common location of the multiple angiokeratomas seen in Fabry disease

A

Lower trunk

156
Q

2 Most common etiologies for erythematous papules or nodules in a lymphocutaneous or sporotrichoid pattern (linear arrangement along lymphatic channels)

A
Sporothrix schenckii (sporotrichosis)
Mycobacterium marinum
157
Q

Most common malignancy associated with Sweet syndrome (pink-red to red-brown edematous plaques that are frequently painful and occur primarily on the head, neck, and upper extremities)

A

Acute myelogenous leukemia

158
Q

Most common location for nodules of erythema nodosum

A

Shin

159
Q

Most common location for lesions of erythema induratum

A

Calf

160
Q

Most common location of the cutaneous lesions in sarcoidosis which are classically red to red-brown in color

A

Face

161
Q

Most common location of angiosarcoma (purple papules and plaques)

A

Scalp and face of elderly patients or within areas of chronic lymphedema

162
Q

Most common location of mucocutaneous ulcers of pyoderma gangrenosum

A

Legs

163
Q

Drugs that are most commonly associated with drug-induced pemphigus

A

Drugs containing a thiol group in their chemical structure (e.g., penicillamine, captopril, enalapril)

164
Q

Most common cutaneous manifestation of dermatomyositis

A

Purple-red discoloration of the upper eyelids, sometimes associated with scaling (Heliotrope erythema) and periorbital edema

165
Q

Most common drugs associated with blistering in drug-related pseudoporphyria

A

NSAIDs

166
Q

Most common of all drug-induced reactions

A

Morbilliform or maculopapular eruptions

167
Q

Most common types of malignancies that arise in organ transplant recipients

A

Basal cell carcinomas and squamous cell carcinomas

168
Q

Most common type of photosensitivity disease

A

Polymorphous light eruption

169
Q

Most common type of porphyria

A

Porphyria cutanea tarda (PCT)

170
Q

Most common cause of neutropenia

A

Iatrogenic (resulting from the use of cytotoxic or immunosuppressive therapies for malignancy or control of autoimmune disorders)

171
Q

Most common neutrophil defect

A

Myeloperoxidase deficiency (a primary granule defect inherited as an autosomal recessive trait)

172
Q

Most common symptom in hereditary hemorrhagic telangiectasia and in boys with VWD

A

Epistaxis

173
Q

Most common symptoms produced by diseases involving the spleen

A

Pain and a heavy sensation in the LUQ

174
Q

Most common source of metastatic tumors in the spleen

A

Melanoma

175
Q

Most common mechanism of pharmacokinetic interactions that cause increased drug effects

A

Inhibition of drug elimination

176
Q

Most common cause of drug-induced hepatotoxicity

A

Acetaminophen overdosage

177
Q

Most common cancer and most common cause of cancer death in the world

A

Lung cancer

178
Q

Second most common cancer worldwide

A

Breast cancer

179
Q

Most common nonskin cancer diagnosed in American males

A

Prostate cancer

180
Q

Most common mutations in oncogenes are found in this family of genes

A

Ras (especially kras)

181
Q

Most common side effect of inhibitors of VEGF (or its receptors)

A

Hypertension

182
Q

Most common mechanism of resistance in anticancer therapies

A

Outgrowth of tumor cells no longer expressing the antigen

183
Q

Most common side effect of chemotherapy administration

A

Nausea, with or without vomiting

184
Q

Most common organism that causes catheter infection in immunocompromised patients that presents as exit-site erythema

A

Coagulase-negative staphylococci

185
Q

Hepatic candidiasis is most common among neutropenic patients being treated for _____

A

AML

186
Q

CMV pneumonia is most common among _____ recipients

A

Hematopoietic stem cell transplant recipients

187
Q

Most common cause of chemotherapy-induced lung disease

A

Bleomycin

188
Q

Most common symptom of urinary obstruction

A

Flank pain

189
Q

Most common cause of malignant spinal cord compression

A

Lung cancer

190
Q

Part of the spine that is the most common site of metastasis that causes cord compression

A

Thoracic spine

191
Q

Most common initial symptom in patients with spinal cord compression

A

Localized back pain and tenderness due to involvement of vertebrae by tumor

192
Q

Most common primary malignancy in brain metastases

A

Lung cancer

193
Q

Most common cause of seizures in patients with cancer

A

Metastatic disease to the CNS

194
Q

2 Most common organs affected by hyperleukocytosis and leukostasis syndrome in acute leukemia

A

Brain and lung

195
Q

Most common cause of malignant upper airway obstruction

A

Lung cancer

196
Q

Most common paraneoplastic syndrome

A

Hypercalcemia

197
Q

Most common cause of hyponatremia among patients with cancer

A

SIADH

198
Q

Most common acute toxicity of chimeric antigen receptor-engineered T cells

A

Cytokine release syndrome

199
Q

Most common serious complications of cancer therapy

A

Neutropenia and infection

200
Q

Most common melanoma

A

Superficial spreading melanoma

201
Q

Most common melanoma in blacks, Asians, and Hispanics and occur as an enlarging hyperpigmented macule or plaque on the palms and soles

A

Acral lentiginous melanoma

202
Q

Most common BRAF mutation

A

Point mutation (T –> A nucleotide change) that results in a valine-to-glutamate amino acid substitution (V600E)

203
Q

Most common cancer in the United States

A

Nonmelanoma skin cancer

204
Q

Most common gene damaged by UV in BCC

A

Hedgehog signaling pathway

205
Q

Most commonly employed method for superficial, minimally invasive nodular BCCs and low-risk tumors

A

Electrodesiccation and curettage (ED&C)

206
Q

Most common cause of cancer death among American men and women

A

Lung cancer

207
Q

Most common form of lung cancer in lifetime never smokers or former light smokers, women, and younger adults

A

Adenocarcinoma

208
Q

Most common life-threatening metabolic complication of malignancy

A

Hypercalcemia (primarily occurring with squamous cell carcinomas of the lung)

209
Q

Most common site for hematogenous spread of gastric tumor

A

Liver

210
Q

Most common primary cancers of the small bowel

A

Adenocarcinomas

211
Q

Second most common liver cancer following HCC

A

Cholangiocarcinoma (CCA)

212
Q

Most common flukes in parasitic biliary infestation

A

Opisthorchis viverrini

Clonorchis sinensis

213
Q

Most common cancer of the biliary tract worldwide

A

Gallbladder cancer

214
Q

Most common neoplasm of the exocrine pancreas and most deadly

A

Pancreatic infiltrating ductal adenocarcinoma

215
Q

Most common mutation in pancreatic ductal adenocarcinoma

A

KRAS (seen in virtually 100% of pancreatic adenocarcinomas)

216
Q

Most common site for neuroendocrine tumors

A

GI tract

217
Q

Most common cause of carcinoid syndrome

A

Small intestinal carcinoids (due to metastatic disease in the liver)

218
Q

Most common symptoms of rectal carcinoids

A

Melena/bleeding (39%)

219
Q

2 Most common symptoms of carcinoid syndrome

A

Flushing and diarrhea

220
Q

Most common presenting symptom of gastrinoma (Zollinger-Ellison syndrome)

A

Abdominal pain (70-100%)

221
Q

Most common clinical symptoms of insulinomas are due to the effect of _____

A

Effect of hypoglycemia on the CNS (neuroglycopenic symptoms)

222
Q

Most common symptom of VIPoma

A

Abdominal pain (30-80%)

223
Q

Renal cell carcinoma is most commonly detected as

A

Incidental finding on a radiograph

224
Q

Most common urinary tract cancer histology that is observed in ~90% of cases

A

Urothelial carcinoma (formerly referred to as transitional cell carcinoma)

225
Q

Most common manifestation of castration-resistant prostate cancer

A

Rising PSA

226
Q

Most common reason men seek treatment for BPH

A

Symptomatic relief

227
Q

Most common pharmacologic agents for the treatment of overactive bladder symptoms

A

Anticholinergics

228
Q

Most common approach after orchiectomy in stage I testicular cancer

A

Active surveillance

229
Q

Most common histological variant of ovarian neoplasms

A

Epithelial tumors

230
Q

Most common heritable abnormality linked to ovarian cancer

A

Germ-line mutation in either BRCA1 or BRCA2

231
Q

Most common presentation of ovarian cancer

A

Stage IIIC (defined as tumors with bulky intraperitoneal disease or positive lymph node involvement)

232
Q

Most common germ cell neoplasm of the ovary and often presents in young women

A

Benign teratoma (or dermoid cyst)

233
Q

Most common malignant transformation of ovarian cancer in older women

A

Squamous cell carcinomas

234
Q

Second most common and the most lethal malignancy in women worldwide

A

Cervical cancer

235
Q

Most common finding upon physical examination in cervical cancer

A

Visible tumor on the cervix

236
Q

Most common gynecologic malignancy in the United States

A

Endometrioid histologic subtype of endometrial cancer

237
Q

Most common location of trophoblastic tumors

A

Uterus

238
Q

Most common type of malignant primary brain tumor

A

Gliomas (derived, based on their presumed lineage, into astrocytomas and oligodendrogliomas)

  • specifically: Grade IV astrocytoma (glioblastoma)
239
Q

Most common brain tumor of childhood

A

Pilocytic astrocytomas (WHO grade I)

240
Q

Most common malignant brain tumor of childhood

A

Medulloblastomas (~20% of all primary CNS tumors among children)

241
Q

Most common primary brain tumor

A

Meningiomas

242
Q

Most common schwannomas

A

Vestibular schwannomas or acoustic neuromas

243
Q

Most common cause of hemorrhagic brain metastases

A

Lung cancer

244
Q

Most common hematologic malignancy that metastasizes to the subarachnoid space

A

Acute leukemia

245
Q

Most common malignancy that metastasizes to the epidural space

A

Malignancies that spread to bone, such as breast and prostate

246
Q

Type of RT that most commonly leads to leukoencephalopathy

A

WBRT (as opposed to focal RT)

247
Q

Most common presentation of soft tissue sarcoma

A

Asymptomatic mass

248
Q

Most common site of metastasis of soft tissue sarcoma

A

Pulmonary parenchyma

249
Q

Most common malignant tumors of bone

A

Plasma cell tumors

250
Q

Most common cause of humoral hypercalcemia of malignancy

A

Overproduction of PTHrP

251
Q

Most common cause of ectopic ACTH

A

Small cell lung carcinoma

252
Q

Most commonly associated tumor in cancer-associated retinopathy (paraneoplastic cone and rod dysfunction characterized by photosensitivity, progressive loss of vision and color reception, central or ring scotomas, night blindness, and attenuation of photopic and scotopic responses in the electroretinogram)

A

Small cell lung cancer (SCLC)

253
Q

Most common type of anemia

A

Hypoprofliferative anemi

254
Q

Most common type of hypoproliferative anemia

A

Iron deficiency anemia

255
Q

2 Most common causes of increased red cell protoporphyrin levels

A

Absolute or relative iron deficiency and lead poisoning

256
Q

Most common genetic disorders in the world, affecting nearly 200 million people worldwide

A

Thalassemias

257
Q

Most common structural hemoglobinopathy

A

Sickle cell disease

258
Q

Most common clinical manifestation of vasoocclusion in sickle cell anemia

A

Painful crises (recurrent episodes manifesting as acute pain and tenderness, fever, tachycardia, and anxiety)

259
Q

Most common cause of megaloblastic anemia due to cobalamin deficiency in infancy in Western countries

A

Selective malabsorption of cobalamin with proteinuria (Imerslund’s syndrome; Imerslund-Grasbeck syndrome; Congenital cobalamin malabsorption; Autosomal recessive megaloblastic anemia; MGA1)

260
Q

Most common cause of death in paroxysmal nocturnal hemoglobinuria

A

Venous thrombosis

261
Q

Most common type of Fanconi anemia

A

Type A

262
Q

Most common early symptom of aplastic anemia

A

Bleeding

263
Q

Most common myeloproliferative neoplasm

A

Polycythemia vera

264
Q

Most common cytogenetic abnormality in polycythemia vera

A

Loss of heterozygosity on chromosome 9p involving the segment containing the JAK2 locus due to mitotic recombination (uniparental disomy)

265
Q

Hemorrhagic complications are most commonly and, classically, found in this type of AML

A

Acute promeylocytic leukemia

266
Q

Gum hypertrophy, which is caused by leukemic infiltration, is most commonly found in this leukemia

A

Monocytic leukemia

267
Q

Most common physical finding in chronic myelogenous leukemia

A

Splenomegaly

268
Q

Most common presentation of chronic lymphocytic leukemia

A

As an incidental diagnosis made at the time of medical evaluation for another cause; routine blood work demonstrating an elevated lymphocyte count in asymptomatic individuals

269
Q

Most common autoimmune cytopenia in CLL

A

Autoimmune hemolytic anemia (AIHA)

270
Q

Richter’s transformation is when CLL transforms to an aggressive lymphoma, most commonly _____

A

Diffuse large B-cell lymphoma (DLBCL)

271
Q

Most common histologic subtype of NHL

A

Diffuse large B-cell lymphoma (DLBCL)

272
Q

Most common presentation for follicular lymphoma

A

New, painless lymphadenopathy

273
Q

Most common site of MALT lymphoma

A

Stomach

274
Q

Most common cytogenetic abnormality in MALT lymphomas (50%)

A

t(11;18)

275
Q

Most common chemotherapy regimen used to treat Hodgkin’s lymphoma

A

ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine)

276
Q

Most common setting for primary effusion lymphoma

A

Immune deficiency disease, especially AIDS

Caused by HHV-8/Kaposi’s sarcoma herpes virus

277
Q

Most common site of extranodal NK/T-cell lymphoma

A

Nasal cavity

278
Q

Most common site of enteropathy-type T cell lymphoma

A

Jejunum or ileum

279
Q

Most common symptom in myeloma

A

Bone pain

280
Q

Most common infections in patients with myeloma

A

Pneumonia and pyelonephritis

(Most frequent pathogens are S. pneumoniae, S. aureus, and K. pneumoniae in the lungs, and E. coli and other gram-negative organisms in the urinary tract)

281
Q

Most common cause of renal failure in multiple myeloma

A

Hypercalcemia

282
Q

Most common heavy chain disease among plasma cell disorders

A

Alpha heavy chain disease (Seligmann’s disease)

283
Q

Most prevalent familial amyloidoses, which is in turn most commonly due to mutation in _____

A

ATTR, due to mutation in transthyretin (TTR)

284
Q

Most common form of localized amyloidosis

A

AB (A beta)

285
Q

Most frequently involved organ in AL amyloidosis

A

Kidneys

286
Q

Most common cause of incompatibility during pretransfusion screening

A

Antibodies to Lewis system carbohydrate antigens

287
Q

Most common cause of thrombocytopenia

A

Drugs (Including nonprescription and herbal remedies)

288
Q

Most common noniatrogenic cause of thrombocytopenia

A

Viral and bacterial infections

289
Q

Most common inherited disorders of platelet function

A

Secretion defects (prevent normal secretion of granule content)

290
Q

Most common inherited bleeding disorder

A

VWD (most common type is type 1 disease)

291
Q

Most common setting of acquired VWD

A

Monoclonal gammopathy of undetermined significance (MGUS)