Mosaicism - Lecture 11 Flashcards
1
Q
Mosaicism
A
Two or more genetically distinct cell lines
2
Q
General features of mosaicism
A
- Areas of hypo and hyperpigmentation
- Facial and body asymmetry
- Hypomelanosis of Ito - Tiger stripes
3
Q
Nondisjunction
A
After conception has less severe phenotype than
4
Q
Diploid/Triploid
A
Must start as triploid (must start with dispermy or digyny)
5
Q
Pallister-Killian Syndrome
A
Always mosaic 12p
6
Q
Four main types of mosaicism
A
- Single-cell mosaicism (level 1)
- Pseudomosaicism (Level 2)
- Confined placental mosaicism
- True mosaicism (Level 3)
7
Q
Cancer
A
Acquired somatic mosaicism
