Morphological

Question 1

Morphology of Campylobacter

Answer 1

Gram -ve rods
Non spore forming
Curved, comma, S or gull wing shaped
Motile with single polar flagella
Microaerophilic
Thermophilic
Oxidase +
Catalase +
Doesnt ferment carbohydrates

Question 2

Species Campylobacter

Answer 2

C jejuni
C coli
C fetus

Question 3

Transmission of Campylobacter

Answer 3

Feco oral route
Zoonotic
Poultry meat
Puppies with diarrheoa
Unpasteured milk
Water contaminated with animal feces

Question 4

Antigenic structure of Campylobacter

Answer 4

Lipopolysaccharide (endoroxin)

Question 5

Virulence factors of Campylobacter

Answer 5

Enterotoxin
Endotoxin
Invasiveness
Capacity to adhere to tissues

Question 6

Pathogenesis of Campylobacter

Answer 6

Infective dose:10^4 organism
Organism multiplies in the small intestine.
Invades the epithelium producing inflammation.
Rbc wbc present in stool ( bloody diarrheoa)
Occasionally blood stream is invaded and systemic infection occurs.

Question 7

Clinical features of Campylobacter

Answer 7

1.Acute onset of abdominal pain.
2. First watery foul smelling diarrheoa followed by bloody diarrheoa
3. Fever
4. Malaise
5. Systemic infections occur mostly in neonates and immunocompromised person
6. Certain serotypes are associated with post diarrheoal guillian barre syndrome
7. Infection is also associated with autoimmune diseases like reactive arthritis and reiters syndrome.

Question 8

Guillian barre syndrome

Answer 8

It is an autoimmune disease
Attributed yo the formation of ab against c. Jejuni that cross reacts with ag of neuron resulting in ascending paralysis.

Question 9

Lab diagnosis of Campylobacter

Answer 9

Specimen: stool
Smear: gram stained smears of stool show typical darting motility of the organism
Culture : skirrows media which is selective media. It contains
Vancomycin
Trimethoprim
Cephalothin
Polymixin
Amphoterecin B
. Biochemical test
oxidase +
catalase +