Mood Disorders (Week 3) Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

Structure of Mood Disorders: Part 1

A
Unipolar disorders (at one ‘pole’)
• Typically depression
• Mania by itself is rare (> in adolescents?) so even then is classified as “bipolar”  as most who experience mania will go on to develop depression
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2
Q

Structure of Mood Disorders: Part 2

A

Bipolar disorders
• Depression and mania alternates i.e. one pole to another – but misleading as not exactly at opposite ends – but independent
• Also Mixed features (at same time) can apply for either a depressive or manic episode e.g. being manic but also having symptoms of depression or depressed with symptoms of mania.

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3
Q
  1. MAJOR DEPRESSIVE EPISODE: Part 1
A

A. Five of more of the following present in same two weeks, representing a change from previous functioning, and at least one of the following:

  • Depressed mood. Reports from self or others (sad, empty or appears tearful). May present as irritability
  • Loss of interest in previously enjoyed activities
  • Decrease or increase in appetite (weight loss or gain)
  • Changes in sleep - too much or too little
  • Restlessness (agitation) or lethargy (retardation) nearly every day
  • Frequent fatigue or loss of energy
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4
Q
  1. MAJOR DEPRESSIVE EPISODE: Part 2
A
  • Impaired concentration and memory. Indecisiveness
  • Inappropriate feelings of guilt, blame and self-worthlessness
  • Recurrent thoughts of death, suicidal thoughts, possibly with suicidal plan, or suicide attempt

B. Causes clinical significant distress or impairment in functioning (in milder cases functioning may appear normal but requires markedly increased effort)

C. Episode is not attributable to the physiological effects of a substance or another medical condition

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5
Q

Signs and Symptoms of Depression

A

FEEL:
>. Sad, Anxious, Worthless, Empty, Guilty, Irritable, Restless
THINK:
>. Poor memory, Concentration, Contemplate suicide, Hopeless, Helpless
BEHAVE:
Eat more/less, Sleep more/less, Lose interest, No pleasure, Attempt suicide
BODILY:
Fatigue, Low energy, Digestive problems, Aches, Pains

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6
Q

MOTIVATIONAL DIFFICULTIES

A
  • Person presenting as increasingly bored and withdrawn
  • Decreased interest in occupational/ academic activities
  • Impaired work performance
  • Helplessness, impaired, problem-solving skills
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7
Q

BEHAVIOURAL DIFFICULTIES

A
  • Getting into fights and arguments
  • Increase in occupational difficulties (e.g. lateness, absenteeism, failure to complete work)
  • Impaired concentration/easily distracted
  • Changes in social activities (e.g. spending increased time alone, break down in established relationships)
  • Increased alcohol or drug use
  • Increased recklessness (e.g. reports of dangerous driving, unsafe sex, criminal activity, etc)
  • Self-harm (e.g. cutting, overdoses)
  • Suicide attempts and other suicidal behaviours (e.g. threats, notes, etc)
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8
Q

RULE OUTS

A

Depression may be a feature of another a mental health problem (e.g. anxiety, schizophrenia, bipolar disorder, etc) – high co-morbidity.

Example:
Normal Grieving Process (e.g. Bereavement, break-
up of a relationship) – BUT depression can occur
subsequent to these events

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9
Q

HOW DO WE KNOW WHEN IT’S A DISORDER? Part 1

A

Context in classification:
• Variations in mood occur in response to life events and
is to be expected and normal (absence can be significant!)
• Pathological changes may occur ‘out of the blue’,
without a significant event that explains intensity, duration or onset i.e. out of context

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9
Q

HOW DO WE KNOW WHEN IT’S A DISORDER? Part 1

A

Context in classification:
• Variations in mood occur in response to life events and
is to be expected and normal (absence can be significant!)
• Pathological changes may occur ‘out of the blue’,
without a significant event that explains intensity, duration or onset i.e. out of context

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10
Q

HOW DO WE KNOW WHEN IT’S A DISORDER? Part 2

A

Continuum between normal and abnormal:
• Blurry, but consider intensity, duration – outside
boundaries of normal experience because of intensity
and duration; effect on functioning
• Depression is a feature of many disorders

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11
Q
  1. MANIC EPISODE: Part 1
A

A. A distinct period of abnormally or persistently elevated, expansive or irritable mood, and abnormally and persistently increased activity or energy, lasting at least a week and present most of the day, nearly every day (or any duration if hospitalization is necessary) (on top of the world, haphazard enthusiasm)
B. During the period, 3 or more of following symptoms (4, if the mood is only irritable) present to significant degree and represent a change in behaviour:

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12
Q
  1. MANIC EPISODE: Part 2
A
  • Inflated self-esteem or grandiosity (e.g. multiple overlapping new projects with little knowledge, uncritical self-confidence, can be delusional)
  • Decreased need for sleep
  • Excessive talking or pressured speech (rapid, loud, hard to interrupt, talk without regard, forceful, theatrical)
  • Racing thoughts or flight of ideas (evident in speech – continuous flow and abrupt shifts)
  • Extreme distractibility (inability to censor)
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13
Q
  1. MANIC EPISODE: Part 3
A
  • Increase in goal-directed activity (e.g. highly productive (?) at work or school, increased social or sexual activity) or psychomotor agitation (e.g. purposeless activity)
  • Excessive involvement in activities that have a high potential for painful consequences (e.g. buying sprees, sexual promiscuity, worthless investments)

C. Severe enough to cause marked impairment, or necessitate hospitalization to prevent harm to self or others, or there are psychotic features
D. Not attributable to physiological effects of a substance or other medical condition

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14
Q

IN CHILDREN (SOME NOTES): Part 1

A

A. Happiness, silliness and ‘goofiness’ are normal in many social contexts:
• If these symptoms are recurrent, inappropriate to the context, and beyond what is expected for the developmental level of the child, they may meet mood requirement of persistently elevated mood.
• Must be distinctly increased from the child’s baseline and accompanied by increased activity or energy levels that
to those who know the child well are clearly unusual for that child.

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15
Q

IN CHILDREN (SOME NOTES): Part 2

A

B:
• Inflated self-esteem or grandiosity (overestimation of abilities may be normal but when these are present
despite clear evidence to contrary, or child attempts dangerous feats, and this differs from baseline, may be
grandiose).
• Increase in goal-directed activity (can be difficult to ascertain but when takes on many tasks simultaneously, devises elaborate and unrealistic plans for projects, has developmentally inappropriate sexual preoccupations) -
should be a change

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16
Q
  1. HYPOMANIC EPISODE: Part 1
A

A. A distinct period of persistently elevated, expansive, or irritable mood and abnormally and persistently increased activity or energy, lasting at least 4 consecutive days, present most of the day, nearly every day

B. During the period, 3 or more of the following symptoms (4 if mood is irritable) have persisted, represent a noticeable change from usual behaviour and have been present to a significant degree (see list of mania symptoms)

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17
Q
  1. HYPOMANIC EPISODE: Part 2
A

C. The episode is associated with unequivocal change in functioning uncharacteristic of the individual when not symptomatic

D. Disturbance in mood and change in functioning are observable by others

E. Episode is not severe enough to cause marked impairment in functioning; no psychotic features; no hospitalization

F. Not attributable to physiological effects of a substance or other medical condition

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18
Q

RECAP: CRITERIA FOR DEFINING ABNORMALITY

A

A psychological disorder – a psychological dysfunction
within an individual associated with distress or impairment in functioning and a response that is not typical or culturally expected.

  1. Dysfunction
  2. Significant impairment
  3. Emotional distress
  4. Help-seeking
  5. Atypical
  6. Not culturally expected
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19
Q

DEPRESSIVE DISORDERS: Part 1

A

Differ in terms of duration, timing, perceived aetiology
1. Major depressive disorder
• single episode or recurrent
2. Persistent depressive DO (dysthymia)
Vary according to frequency, severity, course.

Specifiers: psychotic, anxious distress, melancholic, catatonic, mixed, seasonal, peripartum

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20
Q

DEPRESSIVE DISORDERS: Part 2

A

Other:
3. Premenstrual Dysphoric Disorder,
4. Disruptive Mood Dysregulation Disorder
Also:
• Substance/Medication Depressive Disorder
• Depressive Disorder due to Another Medical Condition
• Other Specified Depressive Disorder
• (Prolonged Grief Disorder – but classified under Trauma and Stressor-related Disorders, new in DSM5-TR)

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21
Q

DSM-5-TR: MAJOR DEPRESSIVE DISORDER: Part 1

A

D. At least one major depressive episode is not better explained by schizoaffective disorder and is not superimposed on schizophrenia, schizophreniform disorder, delusional disorder, or other specified and unspecified schizophrenia spectrum and other psychotic disorders.

E. There has never been a manic or hypomanic episode.

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22
Q

DSM-5-TR: MAJOR DEPRESSIVE DISORDER: Part 2

A

Specify the clinical status and/or features of the current or most recent major depressive episode:

Single episode or recurrent episode; Mild, moderate, severe; With anxious distress; With mixed features; With melancholic features; With atypical features; With mood-congruent psychotic features; With mood-incongruent psychotic features; With catatonia; With peripartum onset; With seasonal pattern (recurrent episode only); In partial remission, in full remission

23
Q

PERSISTENT DEPRESSIVE DISORDER

A

• The disorder represents a consolidation of DSM-IV-defined major depressive disorder (which is chronic) and dysthymic disorder.
• Can be: Fewer symptoms/ not all the symptoms e.g. suicidal ideation?
– but depressed mood most of the day for more days than not
• 2+ years
• No more than 2 mths symptom free
• Chronic? Symptoms can persist unchanged over long periods
• Persistent, and considered more severe than MDD
• (Higher rates of co-morbidity, less responsive to treatment)
• May include periods of MDE symptoms i.e. MDD may precede PDD, and major depressive episodes can occur during PDD

24
Q

DSM-5-TR CRITERIA FOR PERSISTENT DEPRESSIVE

DISORDER: Part 1

A

A. Depressed mood most of the day, most days for at least 2 years (In children and adolescents the mood can be irritable and duration at least 1 year)
B. Presence, while depressed, of at least two of:
• poor appetite or over-eating
• insomnia or hypersomnia
• low energy or fatigue
• low self esteem
• poor concentration or difficulty making decisions
• feelings of hopelessness

25
Q

DSM-5-TR CRITERIA FOR PERSISTENT DEPRESSIVE

DISORDER: Part 2

A

C. Symptoms constant – not absent for more than 2 mths in 2 yrs
D. Criteria for MDD could be continuously present for 2 years
E. No manic or hypomanic episode
F. Not better explained by other mental health diagnoses
G. Not due to a substance or medical condition
H. Causes distress or impairment
Note: If major depressive episode diagnosis is warranted in the 2-year time period, then a separate diagnosis of MDD should be made in addition to PDD

26
Q

TYPES OF PDD

A

> . ‘Mild’ depressive symptoms without any major depressive episodes in 2 years (“with pure dysthymic syndrome”)

> . ‘Mild’ depressive symptoms with additional major depressive episode/s occurring intermittently (“with intermittent major depressive episode/s, with or without
current episode”, previously called “double depression”)

> . Major depressive episode lasting 2+ years (“with persistent major depressive episode”)

27
Q

ADDITIONAL DEFINING CRITERIA FOR DEPRESSIVE

DISORDERS: Part 1

A

Symptom Specifiers
• Mild, moderate, severe
• Psychotic features (Hallucinations/Delusions – mood congruent or incongruent)
• Anxious distress (not sufficient to meet criteria for anxiety DO)
• But comorbid disorders = common
• Mixed features - At least 3 symptoms of mania
• Melancholic - Severe somatic symptoms, inability to experience pleasure, early morning awakening, depression worse in morning, lethargy/agitation, loss of appetite, guilt

28
Q

ADDITIONAL DEFINING CRITERIA FOR DEPRESSIVE

DISORDERS: Part 2

A
  • Atypical features - Oversleeping and overeating
  • Catatonic features – absence of movement/ stupor, muscles are waxy or semi rigid; or, excessive purposeless movement
  • Peripartum onset – 13-19% of women; not the same as ‘baby blues’**
  • Seasonal pattern – SAD Seasonal Affective Disorder, 2.7% of the population, higher rates in extreme latitudes with less winter sun – melatonin?
29
Q

DISRUPTIVE MOOD DYSREGULATION DISORDER

A
  • Children have increased diagnosis for bipolar - Bipolar (NOS) in recent years
  • But: often no mania – more irritability, difficulty controlling emotions, hyperarousal, temper tantrums or extreme behavioural dyscontrol, no family history?
  • ADHD? But in this condition = intense negative affect
  • Can precede depression in adulthood
  • Co-morbidity is high
  • Not diagnosed < 6 yrs or > 18 yrs
  • Possibly more in boys?
30
Q

EPIDEMIOLOGY: Disruptive Mood Disorder: Part 1

A

Gender: very common – up to ¼ women; 1/8 of men (NZ – 1 in 6?). Women 2x common
Age: Can occur across all age groups although less likely before teens and manifests differently
• In kids, similar presentation but may be misdiagnosed: ADHD, conduct DO
• Irritability, temper tantrums, fatigue, fussiness, eating and sleep issues
• In kids, 50:50 gender ratio but adolescence = more girls. Older adults: crabby, irritable, physical complaints
• But diagnostic difficulty, equal M:F ratio
• Dementia and depression
• Depression and physical illness and recovery
• (optimism promotes recovery!)

31
Q

EPIDEMIOLOGY: Disruptive Mood Disorder: Part 2

A

> . Increased risk for women of all mood disorders after giving birth
. Culture: Occurs across cultures but reported more among Europeans(different expression of depression e.g. physical/ somatic complaints amongst Asian and African
cultures)
. Social conditons: Greater risk if poverty, lack of education, unemployment. Chronicity may be higher in lower socio-economic groups (adversity, racism,
discrimination, lack of access to quality care)

32
Q

ONSET AND DURATION: Disruptive Mood Disorder.

A

• Risk for MDD low until teens
• Onset average 30 years old for depression
5-12 years 5% 13-17 years 19%
18-23 years 24% 24-30 years 16%
Lower in middle adulthood but again higher with older adults
• Duration 2 weeks to several years for depression, but note that most recover
• Early onset = poorer prognosis in dysthymic
• Dysthymic disorder may last 20 to 30 years
• 35-85% of single episode of depression have a 2nd episode; median episodes for lifetime = 4-7; with duration of 4-5mths
• Incidence increasing! Reasons???

33
Q

BIPOLAR 1 DISORDER: Part 1

A

Bipolar I Disorder
A. Criteria have been met for at least one manic
episode (Criteria A-D under “Manic episode” - list)
B. At least one manic episode is not better explained
by schizoaffective disorder and is not superimposed
on schizophrenia, schizophreniform disorders,
delusional disorder, or other specified or
unspecified schizophrenia spectrum and other
psychotic disorder.

34
Q

BIPOLAR 1 DISORDER: Part 2

A
  • Called ‘manic depression’ in past
  • One manic episode is sufficient to warrant a diagnosis of bipolar I disorder (but typically also meet criteria for MDE, and rends to be a course of recurring mood episodes)
  • Alternating major depressive and manic episodes (manic episode may have been preceded or followed by hypomanic or depressive episodes – list criteria)
  • ‘Bi’ = two; polar –north and south poles – but not really always extreme opposites?
35
Q

DSM-5-TR CRITERIA: BIPOLAR II DISORDER: Part 1

A

A. Criteria have been met for at least one hypomanic episode and at least one major
depressive episode.
>. Criteria for a hypomanic episode are identical to those for a manic episode (see DSM-5-TR), with the following distinctions: 1) Minimum duration is 4 days; 2) Although the episode represents a definite change in functioning, it is not severe enough to cause marked social or occupational impairment or hospitalization; 3) There are no psychotic features.
B. There has never been a manic episode.

36
Q

DSM-5-TR CRITERIA: BIPOLAR II DISORDER: Part 2

A

C. At least one hypomanic episode and at least one major depressive episode are not better explained by schizoaffective disorder and are not superimposed on schizophrenia, schizophreniform disorder, delusional disorder, or other specified or unspecified schizophrenia spectrum and other psychotic disorder.

D. The symptoms of depression or the unpredictability caused by frequent alternation between periods of depression and hypomania causes clinically significant distress or impairment in social, occupational, or other important areas of functioning.

37
Q

CLASSIFICATION ISSUES, AND DIFFERENCE BETWEEN

BIPOLAR 1 AND 2

A

> . A person with bipolar II experiences hypomanic
episodes but not manic episodes
. While bipolar II may not require hospitalisation, it is no
longer thought of as less severe than bipolar I -burden of
depression, instability of mood experienced is often
accompanied by serious impairment in work and social
functioning
. If there are psychotic symptoms, then not bipolar II
. Co-morbidity very common e.g. anxiety, substance use
disorders, personality disorder
. Bipolar II: illness may be more chronic and on average
spend more time in depressive phase of illness
. NB: same specifiers as for MD, but also rapid
cycling specifier

38
Q

CYCLOTHYMIC DISORDER

A

Less severe but constant mood swings?
- a chronic fluctuating mood disturbance
>. Over 2 years or more
– hypomanic highs and dysthymic lows that do not meet criteria for epsidoes
>. Individual has not been present without symptoms for more than 2 months at a time - Can worsen over time and develop into bipolar – Persistent/ chronic

39
Q

BIPOLAR 1 DISORDER EPIDEMIOLOGY: Part 1

A
  • 1.5% of population?
  • > 90% who have a manic episode go on to have recurrent mood episodes
  • Most go through 4 cycles within 10 years, but without treatment intensifies
  • Rapid cyclers (specifier) can have as many as 4 episodes per year
  • Others may be symptom free for years
  • Between episodes, return to normal functioning but 20-30% continue to experience mood disturbances
40
Q

BIPOLAR 1 DISORDER EPIDEMIOLOGY: Part 2

A
  • High risk of suicide attempts
  • Bipolar – even rates M:F (but women more likely to have rapid cycling or depressive symptoms)
  • Peak age of onset between 20-30 years but can occur throughout life cycle
  • Children – caution, and judge in terms of baseline for young person
  • Greater in high income countries? (Some research - exception: Japan)
  • Creative?
41
Q

FACTS AND FIGURES NZ:

A

• Research has indicated a possible contagion
effect where exposure to a peer, family or media suicide may increase the risk of suicide.
BUT caution…..
• More females than males attempt suicide
• More males than females die as a result of suicide
• The high rate of female attempts reflects high rates of depressive and anxiety disorders in young females
• The high completion rates in young males
reflect a tendency to choose more lethal methods

42
Q

PREDICTORS (?) AND WARNING SIGNS

A
  • Previous attempt of suicide
  • Unexpected reduction of performance
  • Ideas and themes of depression, death and suicide
  • Giving away prized possessions
  • Indirect or direct threats of suicide
  • Change in mood
  • Grief about a significant loss
  • Withdrawal from relationships
  • Physical symptoms with an emotional cause
  • High risk behaviours (e.g. dangerous driving, substance abuse, unsafe sex and playing with weapons)
  • Recent suicide of a friend or family member
43
Q

MANAGEMENT OF RISK:

A

> . Any threat should be taken seriously and investigated
further; Any person considered at risk should be assessed
. It is important to remove all lethal means from the person’s
possession and environment (e.g. firearms, ropes, pills and
poisons)
.Referral to help e.g mental health support services (crisis
line phone service (0800 800 717))
. When degree of risk is established, appropriate management plan should be put in place
If doubt exists, immediate consultation with mental health professionals should be sought
. Prompt and continued liaison with families of at risk
adolescents should be arranged by the school whenever
possible
. Any person considered at risk should be treated as being at risk until clearly that risk no longer exists

44
Q

CAUSES: BIOLOGICAL

A
  • Genetic (dep and anxiety?) – evidence for familial link and underlying vulnerability (Higher for bipolar)
  • Neurotransmitters? (serotonin? Especially in relation to other NT’s?)
  • Hormonal (e.g postnatal?) Cortisol? (stress hormone)- elevated in depression; decreases neurogenesis in hippocampus (some suggestion that bipolar exacerbated during premenstrual period, perimenopause and after birth)
  • Sleep rhythms – quicker and more intense REM
  • Structural
  • Gut health/ micronutrients
45
Q

CAUSES: SOCIAL/PSYCHOLOGICAL

A
  • Family history
  • Trauma, especially childhood adversity (bipolar)
  • Stressful events – relationship, grief, stressors such as work, financial stressors, accidents
  • Context + meaning, stressful life events are strongly related to the onset of mood disorders, reciprocal model (stress vulnerability)
  • Humiliation, loss and social rejection
  • BUT individuals may also be placing themselves in high-risk/stressful situations
  • More positive set of stressors for mania; then develop ‘life of their own’, sleep deprivation etc
  • Lifestyle factors – diet, exercise, drugs, alcohol, sleep
46
Q

CAUSES: COGNITIVE

A

> . Irrationally negative thoughts re self, world and future.
. Negative self schemas (e.g. unlikable, unlucky,
incompetent) reflected in negative thinking underlying
which are certain types of distortions.
. Seligman and “learned helplessness” –- pessimistic
explanatory style

47
Q

Seligman

A

> . Learned Helplessness: • Lack of perceived control
. Depressive Attributional Style:• i.e. I have no control because I am a failure, things won’t change
• Internal, stable, global.
. Sense of hopelessness: • Lack of perceived control, and inability to regain, leads to decreased attempts to
improve own situation
• Pessimism
• Before or after?/ Cause or effect of depression?

48
Q

BECK’S ‘NEGATIVE COGNITIVE TRIAD’

A

Treatment:
• CBT – change the thinking patterns
1. Identify and monitor dysfunctional automatic thoughts
2. Recognise connections among thoughts, emotions and behaviours
3. Evaluate the reasonableness of these negative thoughts
4. Substitute more reasonable interpretations for the distorted attribution
5. Identify and alter dysfunctional assumptions

49
Q

CAUSES: BEHAVIOURAL

A

> . Interruption of reinforcers
. Increased frequency of punishments
. Decreased effectiveness of reinforcement

Treatment:• Increase reinforcement and reduce punishments – thus, select
realistic goals and rewards for achieving
• Correct deficits in social skills or assertiveness

50
Q

CAUSES: PSYCHODYNAMIC

A
  • Roots in experiences of loss or disappointment that generate anger at the lost person/person that disappointed – anger cannot be acknowledged and is turned inward
  • In adulthood, actual or symbolic losses can reactivate the process.

Treatment:
• Talk therapy
• Interpersonal therapy

51
Q

CAUSES: SOCIO-CULTURAL AND FAMILY PERSPECTIVES

A

Self-esteem issues related to gender, poverty, employment (see NZ study)
• Family issues /Marriage and Interpersonal Relationships
• Relationship disruption precedes depression, but also v.v;
Strongest effects for males after marriage split
• Marital conflict vs. marital support
• Societal issues – expectations, pressure

52
Q

Mood Disorders in Women

A
• Prevalence: Females > males
- True for all mood disorders 
• Except bipolar
• Gender roles 
• Perceptions of 
uncontrollability/helplessness
• Socialization (parenting styles)
• Women ‘ruminate’ more; self-blame – men engage in activity
• Access to resources
53
Q

SOCIAL AND CULTURAL DIMENSIONS

A

> . Social Support
• Related to depression
• Lack of support - predicts late onset depression
• Substantial support - predicts recovery for depression (not mania)

(think also Pat Deegan – recovery as a journey of the heart)

54
Q

MULTIPLE CAUSALITY

A
An integrative theory:
• Shared biological vulnerability 
• Psychological vulnerability
• Exposure to Stress
• Social and interpersonal relationships
• Interaction of biology and psychosocial factors
Combination treatments often work best! CBT and IPT Outcomes:
• Comparable to medications
• More effective than placebo
55
Q

STAYING WELL

A
Preventative approaches – staying well
• Maintenance treatment
Health promotion/ positive psychology
• Regulating/ accepting emotions
• Mindfulness
• Managing/accepting thoughts or reducing their effect
• Lifestyle factors
• Social support
• “Psychological immunisation”