Mood disorders Flashcards
What is the most appropriate antidepressant to prescribe following an MI
Setraline
antidepressant of choice if required in children/adolescents
fluoxetine
why are MAOIs not routinely used?
what are they reserved for?
they can cause hypertensive crisis if you dont stick to strict dietary requirements (no tyramine containing foods)
Reserved for atypical depression
tx of hypertensive crisis
alpha blockade
adverse effects of SSRIs
sexual dysfunction, short term anxiety..
which antidepressants can have adverse effects on cardiac function?
TCAs
BZD overdose, antagonist?
flumazenil
1st line drug tx for anxiety
BZD but recommended short term to avoid dependence
Endocrine changes in major depression
^ CRH in CSF
^ secretion of cortisol
»» hippocampus SHRINKS in response to cortisol, and the hippocampus is essential in short term memory function
enlarged adrenal glands
50-70% fail to suppress cortisol following dexamethasone
^TRH in CSF
atypical depression features
mood reactivity significant weight gain hypersomnia leaden paralysis interpersonal rejection sensitivity
waking > 2 hrs before usual, depression worse in morning, loss of appetite etc… is a feature of ?
somatic syndrome
Hypomanic episode - abnormally elevated/irritable mood for how long?
more than or equal to 4 days
manic episode - sustained for how long?
more than or equal to a week
True or False: 1/3 of sufferers of panic disorder develop agoraphobia
false, 2/3!!!!
What percentage of those with social phobia abuse alcohol
20%