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PSYCHOLOGY > Mood Disorders > Flashcards

Mood Disorders Flashcards

1
Q

Depression Dx

A

5/9 symptoms (1 must be anhedonia) for 2+ weeks :
Sleep changes, Interest↓ (anhedonia), Guild, Energy↓, Concentration problems, Appetite changes, Psychomotor retardation or agitation, Suicide

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2
Q

Dysthymia Dx

A

3/9 symptoms for 2+ years (cannot have gone more than 2mo w/o symptoms)

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3
Q

Physiologic cause of depression

A

↓NE, ↓serotonin, ↓DA d/t post-synaptic receptor problem

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4
Q

Mania Dx

A

euphoric mood for 1+ week + 3 DIGFAST symptoms (distractibility, irresponsibility, grandiosity, flight of ideas, activity↑/agitation, sleep↓, thoughtlessness/talkativeness)

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5
Q

Hypomania Dx

A

euphoric mood for 4days - less severe, no psychosis

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6
Q

Bipolar Type I Dx

A

1 manic episode (+/- MDD)

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7
Q

Bipolar Type II Dx

A

Hypomania + MDD

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8
Q

Cyclothymic Disorder

A

mild depression + mild hypomania that lasts 2+ years

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9
Q

NT associated w/ mania, psychosis, euphoria, etc

A

high DA & NE & low Serotonin

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10
Q

Atypical depression

A

mood reactivity + hypersomnia + over-eating/weight gain

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11
Q

Peripartum depression

A

onset w/in 4 weeks of delivery , lasts >10d (postpartum blues <10d)

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12
Q

Recurrent Depression

A

period of 2mo rest with NO depressive symptoms

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13
Q

Seasonal affective disorder

A

2+ years with 2 major depressive episodes showing temporal association & no non-seasonal depression

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14
Q

MDD Neuroanatomy

A

Left prefrontal cortex w/ decreased BF

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15
Q

Bipolar Neuroanatomy

A

Right prefrontal cortex w/ decreased BF

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16
Q

Neuroanatomy of MDD & Bipolar

A

high amygdala activity, low cingulate gyrus & hippocampus activity (high cortisol)

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17
Q

Cognitive distortions

A

all or nothing thinking, over-generalization, magnification, jumping to conclusions

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18
Q

Diathesis-Stress Model

A

Biological component (predisposition) + Stressor (environment shapes it)

19
Q

Depression Tx

A
  1. SSRI (MDD w/ atypical)
  2. SNRI (MDD w/ melancholy, diabetic peripheral neuropathy)
  3. TCA (MDD w/ melancholy)
  4. MAO-I
20
Q

Tri-C Syndrome

A

TCA S/E (convulsion, coma, cardiac arrhythmias)

21
Q

TCA S/E

A

Tri-C Syndrome, Orthostatic hypotension, anticholinergic effects

22
Q

Which TCA is very sedating

A

Amitriptyline

23
Q

Which TCA is less sedative, but higher risk for seizures?

A

Desipramine

24
Q

Which TCA is preferred by elderly?

A

Nortriptyline

25
Q

Hypertensive crisis (w/ ingestion of tyramine)?

A

MAO-I - risk of stroke/MI/arrhythmia

26
Q

tranylcypromine, phenelzine, isocarboxazid, slegiline

A

MAO-I

27
Q

What drug can not be mixed with SSRIs & TCAs d/t excessive Serotonin risk?

A

MAO-I (2wk break b/w)

28
Q

Non-responders for MDD Tx

A

SSRIs: + SSRI + lithium + thyroid + bupropion

29
Q

MDD Tx length

A

6 months and then taper gradually over 1-2 weeks

30
Q

Options for non-seponders

A

vagal n. stimulation, transcranial magnetic stimulation, ECT (last line)

31
Q

Bipolar

A
  1. Lithium (acute & long-term)
  2. Anticonvulsants (rapid cyclers)
  3. Atypical antipsychotics (acute)
32
Q

Lithium S/E

A

hypothyroidism, renal dysfunction, seizures, tremors, nephrogenic diabetes insipidus, teratogenic

33
Q

Anticonvulsant Valproate S/E

A

hepatic failure, pancreatitis

34
Q

Anticonvulsant Carbamazepine S/E

A

rash

35
Q

Clozapine S/E

A

Agranulocytosis

36
Q

Bipolar: Acute Manic Phase Tx

A

Lithium +

Oxcarbazepine or valproate +/- benzo

37
Q

Bipolar: Acute Depressive Phase Tx

A

Lamotrigine +

Antidepressant + atypical antipsychotic

38
Q

Bipolar Maintenance:

A

Lithium, Carbamazepine, Valproate, Lamotrigine

39
Q

Suicide risk is most related to

A

degree of hopelessness

40
Q

A depressive episode is not required in which of the following?

A

Bipolar Type I

41
Q

Which antidepressant has a mechanism of action as an α2-receptor antagonist?

A

Mirtazapine

42
Q

Which agent is best known to have SE of decreasing thyroid function?

A

Lithium

43
Q

Drug with significant α1 receptor antagonism, causing orthostatic hypotension?

A

Imipramine

PSYCHOLOGY (6 decks)

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