Mood Disorders Flashcards
What is the cardinal criteria for MDD? And for how long do they have to be present
- 5 of the symptoms are either 1 or 2 (depressed mood most of the day, nearly every day or markedly diminished interest or pleasure in all or almost all activities)
- for a 2 week period
Is MDD episodic? What does that mean? for how long if untreated?
- Typically yes
- It means that there is an end
- 2-9 months
Recurrent vs relapse? About percentage of the population will experience 1+ recurrences?
- relapse is a return of symptoms of the same episode
- recurrent is a return of a whole new episode
- 40-50%
Is depression common? What percent of patients who are depressed will fail to be detected?
- Yes
- 50% so half!
What is the most common age of onset? Does it have high rates of comorbidity?
- late teens/early 20s
- anxiety disorders
What are some functional consequences of depression?
- leading cause of disability worldwide
- even those that don’t fill full DSM criteria are associated with significant impairment
- long term effects in teen years are often felt through young adulthood
What is the hallmark of bipolar disorder? Do you need MDD for bipolar 1 or 2?
- Severity and duration of mania
- need it for bipolar 2
Are mixed symptoms common? What does that mean? And what is it high risk for?
- Yes
- A bit of N pole and S pole (sad and happy) @ same time
- suicide
Is Manic episode more severe for bipolar 1 or 2?
What is the cardinal? Lasting for how long?
- Bipolar 1
- A distinct period of persistently elevated or irritable mood and increased goal directed activity
- lasting for 1 week
What is the average age of onset? Is there any gender differences like in MDD?
- In 20s
- There are no gender differences
Is there a high rate of misdiagnosis and how long is the diagnostic delay?
- Yes
- the diagnostic delay is long
What are some consequences of bipolar disorder?
- episodic and recurrent
- high rates of suicide
Are heritability estimates higher in MDD or in BPD? Are they polygenic?
- Higher in BPD
- Highly polygenic
Is depression just an imbalance of serotonin?
- No, it is not!
- There is now a growing focus on complex interactions between neurotransmitters
Depression & Social Factors: Life Stress
- Early adversity
- Major life events
- Chronic stress
- Interpersonal stress