Mood Disorders Flashcards

1
Q

State the ICD-11 Criteria essential for diagnosing a manic episode

A
  1. Both of the following for a period of at least 1 week most of the day nearly everyday
    - Extreme mood stare characterised by Euphoria, uplifted mood, fantastic…
    - Increased activity (cannot sit still)
  2. Several of the following
    - Increased talkativeness or pressured speech + Flight of ideas (illogical switching from one idea to the next)
    - Increased self-esteem/ delusion of grandiosity - brightly coloured flamboyant clothing (feels like they way be famous or accomplish tasks beyond skill level)
    - Increased reckless behaviour (financial/impulsiveness)
    - Increased sexual drive (libido)/sociability (sexual promiscuity)
    - Decreased need for sleep
    - Decreased concentration/distractibility (playing with an object during interview)
    +/- Psychotic symptoms (e.g persecutory delusions of being conspired against because of someone;s special identity or abilities)
    Symptoms are not due to another medical condition (brain tumour), effects of a substance (cocaine, amphetamines), or brain injury
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2
Q

Differentiate between a manic and hypomanic episode in terms of
Symptoms
Psychosis
Duration
Associated bipolar disorder
Impairment in day-to-day functioning

A

Symptoms in hypomania are less severe than in mania. Hypomania is just the persistent elevation of mood (may be represented as just irritability) compared to the manic state which is an extreme mood state. Hypomanic patients are easier to interrupt if they start jumping from one idea to the next and also can sit for the interview a lot more easily.
Psychotic symptoms, including delusions of grandiosity, are not present in hypomania (instead it is just higher self-esteem)
Duration required for diagnosis in hypomania is symptoms occurring most of the time nearly every day for several days instead of for at least a week.
Mania is associated with Bipolar type I, Hypomania is type II
Impairment: Not severe enough to cause impairment in functioning. Manic patients have evident and significant impairment in functioning.

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3
Q

Define and State the ICD-11 guidelines for a mixed episode

A

A mixed episode is characterised by:
- Several prominent manic AND depressive symptoms occurring simultaneously or alternating very rapidly from day-to-day or within the same day
- Symptoms must include an altered mood state consistent with a manic or depressive episode
- Symptoms must be present for at least two weeks (unless shortened by treatment)

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4
Q

If a patient is diagnosed with a mixed episode:
1. Assuming manic symptoms predominate, what are common contrapolar symptoms?
2. Assuming depressive symptoms predominate, what are common contrapolar symptoms?
3. Assuming they are alternating rapidly, what is a characteristic symptom? What would treatment would they require?

A
  1. Dysphoric mood, expressed beliefs of worthlessness, hopelessness, and suicidal ideation
  2. Irritability (present normally is depressed children and adolescents), racing and crowded thoughts, increased talkativeness, and increased activity.
  3. Extreme emotional reactivity (alternating periods of flat affect and intense/exaggerated reactiveness). DBT
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5
Q

A patient you have previously treated sees you again complaining of alternating moods over the past few days after prescribing an SSRI for 2 weeks. What is your plan?

A

Discontinue SSRI as this may be a antidepressant-induced mixed episode. If the symptoms persist after the discontinuing and meet the criteria of a mixed episode, patient becomes diagnosed with a mixed episode.

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6
Q

What are the different possible diagnoses for Depressive Disorders?

A

Single episode depressive disorder
Recurrent depressive disorder
Dysthymic Disorder
Mixed Depressive and Anxiety Disorder
Other specified depressive disorders

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7
Q

Single and Recurrent Episode Depressive Disorder:
How are these disorders classified?
Are there any differences between the disorder? If so what are they?

A

They are classified according to the severity of the episode (mild, moderate, and severe)/stage of remission (partial or full) where moderate and severe episodes are further classified according to the presence or absence of psychotic symptoms.

The only real difference is that recurrent episode needs 2 or more episodes (including current episode) for diagnosis.

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8
Q

T or F: Panic Attacks may occur in depression where recurrent panic attacks are an indication of severity

A

True

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9
Q

What is the average age of onset for depressive disorders

A

Mid-20s

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10
Q

Are depressive disorders more common in women or men?

A

Twice as common in women. Women are also more likely to experience co-occurring anxiety or fear-related disorders as well as appetite changes whereas men are more likely to have alcohol or other substance abuse during the episode. Men are also more impulsive in these states and hence undertake more risky behaviours.

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11
Q

Dysthymic Disorder:
Define and state the ICD-11 features of this disease
How would this disease appear in children and adolescents?
What are the gender differences for this disorder?

A

Persistent depressed mood, lasting 2 years or more, for most of the day, for more days than not. The depressed mood is accompanied by the same yet milder symptoms seen in a depressive episode. There also must have never been a two-week (required for diagnosis of a depressive episode) period in the first two years which the number and duration of symptoms were sufficient to meet the diagnostic requirements for a depressive episode nor a prolonged (>2 months) symptom-free period

Children and adolescents depressed mood can manifest as pervasive irritability

There are no notable differences between genders except in early life where women are more susceptible.

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12
Q

When would you give a diagnosis of “Other specified depressive disorders”

A

When the presentation is characterised by mood symptoms that share primary clinical features with other depressive disorders but do not fulfil the diagnostic requirements for any other disorder in the normal grouping

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13
Q

Mixed Depressive and Anxiety Disorder:
Define and state the ICD-11 guidelines

A

It is characterised by the presence of both depressive and anxiety symptoms for most of the time for a duration of at least 2 weeks yet when considered separately do not meet the diagnostic requirements for another depressive or an anxiety disorder (as well as no history of manic or mixed episodes)

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14
Q

What are some symptoms of anxiety that you would look out for when taking a history from a patient presenting with low mood?

What part of the past medical history would be significant when discussing anxiety and depression?

A

Feeling “on-edge”, Inability to control worrying thoughts, fear that something awful will happen, trouble relaxing, muscle tension, or SYMPATHETIC AUTONOMIC SYMPTOMS (=symptoms of anxiety => sweating, palpitations, dry mouth, lightheadedness/orthostatic hypotension, upset stomach)

Hypothyroidism (more likely than hyper). If this is present, it cannot be diagnosed.

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15
Q

Bipolar Type I Disorder:
Define and State the ICD-11 Criteria for diagnosis

A

The typical course of this disease is characterised by the recurrent depressive and manic (or mixed) episodes. One episode of mania (not hypomania, although that exists in the disorder, it cannot be used in diagnosis) alone is enough to diagnose this.

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16
Q

In combination with a history of one or more depressive episodes, a mixed, manic, or hypomanic episode arising during anti-depressant treatment including medication or ECT, if the symptoms persist after treatment discontinues, how will you diagnose this patient?

A

Bipolar Disorder Type I

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17
Q

What is the most heritable mental disorder?

A

Bipolar Disorders

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18
Q

Individuals initially diagnosed with bipolar type II are at high risk of experiencing a manic or mixed episode during their lifetime. If this occurs, does the diagnosis change?

A

Yes, diagnosis changes to Bipolar Disorder Type I.

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19
Q

What are common medical conditions experienced with patients diagnosed with bipolar disorders? Why?

A

Due to the side effects of bipolar medications, medical conditions affecting the cardiovascular system such as hypertension are common. Glucose levels should be checked before prescribing these medications they also have metabolic effects such as hyperglycaemia.

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20
Q

T or F: More than half of manic episodes are followed by a depressive episode

A

True

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21
Q

T or F: The risk of recurrence increases with each cycle in bipolar disorders.

A

True

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22
Q

T or F: Manic episodes are more common and severe in men and have earlier onset whereas women are more likely to experience depressive episodes, mixed episodes, and rapid cycling.

A

True

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23
Q

Bipolar Disorder Type II:
Define and state the ICD-11 Criteria for diagnosis:

A

Characterised by at least one hypomanic and one depressive episode that are recurring AND with no history of manic or mixed episodes (If present, switch diagnosis to type I)

24
Q

In combination with a history of one or more depressive episodes, a hypomanic episode arising during antidepressant treatment including medication or ECT, if symptoms remain after discontinuing treatment, is this grounds for diagnosis of a bipolar episode? If so, what is the diagnosis?

A

Yes, Bipolar Type II. There must be no history of a manic or mixed episode as well.

25
Q

Why are hypomanic episodes usually assessed retrospectively in patients with bipolar disorder?

A

Patients will usually present during their depressive episodes as they perceive mania/hypomania as improvement in symptoms as there is increased productivity and self-esteem.

26
Q

When is there the greatest risk of a hypomanic episode in women? How would you classify this?

A

During early post-partum period following childbirth. “Current episode perinatal” should be assigned. Can be depression or hypomania in type II. Depression, mania, or hypomania in type I.

27
Q

What is the gender distribution differences between Bipolar Type I and II

A

Type 1 is equally distributed between males and females whereas Type II is skewed towards females.

28
Q

Cyclothymic Disorder:
Define and State the ICD-11 Criteria:
How could this disease be presented in children?

A

Think Dysthymia but alternating with hypomania
It is characterised by mood instability over an extended period of time (two years or more) with numerous hypomanic and depressive episodes. Mood symptoms should be present for more days than not (brief symptom-free periods are consistent but may not exceed 2 months). There cannot be any history of manic or mixed episodes and during the first 2 years of the disorder there has never been a two-week period (needed for diagnosis of a depressive episode) where symptoms meet diagnostic requirements for a depressive episode.

Note: Hypomanic episodes do not need to meet the diagnostic requirements for this diagnosis.

Pervasive irritability

29
Q

Biochemical Hypothesis of Depression:
Define it

A

Definition: The monoamine hypothesis of depression refers to decreased levels of monoamine (Serotonin -main- Dopamine, noradrenaline and neuropeptides/stress hormones) where in contrast, increased levels of monoamines play a role in mania

30
Q

Organic risk factors for depression:
Medications (Give 2)
Endocrine disorders (Give 4)
Neurological disorders (Give 8)
Nutritional disorders (Give 1)
Substance-induced (Give 3)
Infection
Collagen Vascular disorders (SLE, scleroderma, dermatomyositis)
Metabolic: Fe-deficiency anaemia, hypercalcaemia, hyponatraemia, hypomagnesaemia

A

Medications: Steroids (incl. oestrogen) and Beta Blockers, alpha methyldopa
Endocrine: Hypo/hyperthyroidism, Hyperparathyroidism, Cushing’s Syndrome, Diabetes, Addison’s disease
Neurological: Stroke, subdural haematoma, brain tumours, Huntington’s disease, Parkinson’s disease, multiple sclerosis, uncontrolled epilepsy, syphilis, dementia.
Nutritional: Vitamin B12 deficiency, pellagra
Substance-induced: Alcohol, Cocaine, Amphetamines

31
Q

Organic Risk Factors for Mania:
Medications (Give 4)
Substances (Give 3)

A

Medications: Steroids, antidepressants, Levodopa, Thyroxine
Substances: Cocaine, Ecstasy, Amphetamines, Excessive Caffeine.

32
Q

What brain changes are associated with depression?

A

Atrophy of the hippocampus

33
Q

What are the investigations to undertake when dealing with suspected mood disorders? Use the Biopsychosocial approach

A

Biological:
Bloods: FBC, RFTs (lithium), LFT (Alcohol, First-pass metabolism for drugs), TFTs (Hypo/hyperthyroidism), B12 and Folate (alcohol and Korsakoff’s Encephalopathy), Vitamin D, Prolactin (Hyperprolactinemia) HbA1c (Below 5.7%, >6.5% for diabetes), cholesterol and lipids (More for antipsychotics)
Scans: ECG, EEG (can aid in detecting emotion-related psychopathology), CT/MRI (brain scan, for tumours or subdural haemorrhage)
Random supervised urine drug screen

Psychological:
Risk Assessment
Rating Scale: For depression: BDI (Beck’s Depression Inventory) and HAM-D (Hamilton Rating Scale for Depression)
For Mania: Young Mania Rating Scale

Social: Collateral History, Occupational therapy referral, social worker referral

34
Q

After the first Episode there is a 60% chance of having a second, which becomes 70% for the third, and 90% for the 4th. It is also more likely in females.

A

True

35
Q

The frequency and length of a depressive episode increases in frequency and duration as we age

A

True

36
Q

People with depression have a 5x risk of developing an MI

A

True. Think of increased stress => increase BP => Hypertension => increased risk of plaque dislodgement.

37
Q

What are some poor prognostic factors for depression: Think logically

A

Male gender (males have it worse, females more likely to have it)
Insidious onset (slow onset)
Early age onset
Lower socioeconomic group
Poor pre-morbid self-esteem
Comorbid misuse of drugs
Poor support structure
Poor response to tx

38
Q

What is Seasonal Affective Disorder?
What are the unique features of it?
How is it managed?

A

SAD is depression that commences in autumn/winter and ends in spring or summer when the hours of daylight increase

Atypical depressive features: Hypersomnia (not insomnia), Hyperphasia (always hungry) + Carb craving => weight gain.

Management: Light treatment on waking to restore melatonin metabolism, maintenance therapy all winter, avoid bright lights during the night.

39
Q

Rapid Cycling Bipolar Disorder:
What is it?
How is it treated?

A

4 or more depressive, manic, or mixed episodes within 12 months

They are treated the same way you would treat bipolar

40
Q

What is Depressive Stupor:

A

Unresponsive, Akinetic, mute, and fully conscious (following an episode, they can recall everything)

41
Q

What is Grief-Bereavement Reaction?
What is the normal duration?
What are the 4 types of pathological grief reaction?

A

6-12 months

Prolonged grief reaction —> lasting more than 12 months
Delayed grief —> First stage of normal grief (stunned stage) starts at least 2 weeks later
Absent grief —> No reaction
Intense grief: Symptoms are outside normal range and include suicidal ideation, complex hallucinations, excessive guilt, and decreased ability to function normally with daily life

42
Q

Severity of a depressive episode is based on… (give 3)

A

Number and severity of symptoms
Impact on individual’s functioning
With/without psychotic symptoms

43
Q

Depression MSE:
Appearance/behaviour
Speech
Mood/affect
Thought contect
Thought Form
Cognition

A

A&B: Psychomotor retardation/agitation and Disheveled appearance, withdrawn
Speech: Quiet, slow, poverty of content, Brief, undetailed answers
M&A: Low/pervasive mood with blunted/flat affect.
Thought content: Negative attribution bias, Black or white thinking, catastrophisation, personalisation
Thought form: No formal thought disorder but may have poverty of content
Cognition: Reduced concentration=> reduced memory and proper decision-making

44
Q

Mania/Hypomania MSE:
Appearance and Behaviour
Speech
Mood/Affect
Thought Content
Thought Form
Cognition
Insight

A

A&B: Dishevelled, Overfamiliar, Disinhibited, Energetic/Hyperactive/Restless, Agitated
Speech: Rapid, pressures, Nonsensical, loud, inappropriate (Clang associations -Rhyming words, Neologisms, Metonyms - Close words)
Mood: Elated, labile Affect: Reactive, labile
Thought content: Delusions of grandeur/grandiosity
Thought form: Racing thoughts/flight of ideas
Cognition: Enhanced in hypomania but with distractibility comes reduced concentration and memory
Insight: Often very poor as they feel fantastic and may be resistant to tratment.

45
Q

What should be discussed with the patient before prescribing any medication? (Give 3)
What should be discussed in addition to that when prescribing psychotropics (meds in psych)

A

Rationale for prescribing
Main side effects of medicatin
Importance of good compliance

Concerns of over-sedation especially when starting new medication or changing treatment => driving must cease.

46
Q

A patient you have interviewed has met the diagnostic criterial for a manic episode. They are on an antidepressant. What is your biological management?

A

Stop antidepressants
Consider an antipsychotic or mood stabiliser

47
Q

A patient you have interviewed has met the diagnostic criterial for Mania. They are currently on a mood stabiliser. What is your biological management?

A

Check plasma levels of mood stabiliser and increase dosage. If that still doesnt work then consider adding an antipsychotic

48
Q

A patient you have interviewed has met the diagnostic criterial for Mania. They are currently on an antipsychotic. What is your biological management?

A

Check compliance. If compliance is adequate, then add a mood stabiliser

49
Q

A patient you have interviewed has met the diagnostic criterial for Mania. They are on an antipsychotic but report the side effects are too intrusive and bothersome. What is your biological management?

A

Change antipsychotic with preferable side effects and if tx is still insufficient then add a mood stabiliser as well

50
Q

A patient you have interviewed has met the diagnostic criterial for Mania. They are acutely psychotic. What is your immediate biological management? Give specific medications

A

Benzodiazepine specifically a short-term one like Lorazepam or Clonazepam

51
Q

A patient you have interviewed has met the diagnostic criterial for Mania. You prescribe antipsychotics. The consultant asks you when you will see the patient again for review. How about the review after that?

A

4 weeks then review and discuss then another 3-6 months before another review

52
Q

A patient you have interviewed has met the diagnostic criterial for Bipolar depression. They are not on any medications. What is your biological management of this patient?

A

Fluoxetine + Olanzapine or Quetiapine alone. If that doesnt work then Lamotrigine alone

53
Q

A patient you have interviewed has met the diagnostic criterial for Bipolar depression. Theyre currently on Lithium or Sodium valproate. What is your biological management for this patient?

A

Check plasma levels to ensure correct therapeutic dosage and increase if necessary to maximum dosage. If that doesnt work then remove the lithium/valproate and add fluoxetine + Olanzapine or Quetiapine alone. If that doesnt work either then Add Lamotrigine + Lithium/valproate

54
Q

A patient you have interviewed has met the diagnostic criterial for Bipolar depression. You prescribe Quetiapine. The consultant asks you when you will see the patient again for review. How about the review after that?

A

4 weeks then review and discuss then another 3-6 months before another review.

55
Q
A