mood disorders Flashcards
a mood disorder that causes a persistent feeling of sadness and loss of interest
depression
natural response to a loss
grief
painful feelings come in waves often intermixed with positive memories associated with loss (there is little relief)
grief
self esteem is maintained in this feeling
grief
what is the similarity between grief and depression
intense sadness and withdrawal from usual activities
this feeling causes decrease in interest or/and mood
depression
feelings of worthlessness and self loathing are common in this feeling
depression
what are other terms for major depressive disorder
clinical depression
major depression
unipolar depression
what is the dsm-v diagnostic criteria for major depressive disorder
at least 2 weeks of depressive episode
or
at least 4 of the following:
- anhedonia
- appetite disturbance
- sleep disturbance
- psychomotor agitation or retardation
- fatigue (throughout the day)
- feelings of worthlessness
- recurrent suicidal thoughts
what is the feeling of inability to experience pleasure
anhedonia
what are the two types of sleep disturbance
hypersomnia
insomnia
what do you call the type of sleep disturbance where th patient sleeps for long periods
hypersomnia
what is another term for persistent depressive disorder
dysthymia
how many weeks of depressive episode is it needed to diagnose major depressive disorder?
at least 2 weeks
what are the dsm-v diagnostic criteria for persistent depressive disorder
depressed mood for at least 2 years
or
at least two of the following
- appetite disturbance
- sleep disturbance
- fatigue
- feelings of worthlessness
- feelings of hopelessness
- poor concentration or difficulty making decision
what type of depression has
- anhedonia
major depressive disorder
what type of depression has appetite disturbance
major depressive disorder and persistent depressive disorder
what type of depression has sleep disturbance
major depressive disorder and persistent depressive disorder
what type of depression has psychomotor agitation or retardation
major depressive disorder
what type of depression has all day fatigue
major depressive disorder and persistent depressive disorder
what type of depression has feelings of worthlessness
major depressive disorder and persistent
what type of depression has feelings of worthlessness
major depressive disorder and persistent depressive disorder
what depression has recurrent suicidal thoughts
major depressive disorder
what depression has feelings of hopelessness
persistent depressive disorder
what depression has poor concentration or difficulty making decision
persistent depressive disorder
what is the exact cause of depression
unclear
what is the exact cause of depression
unclear
how many percentage of concordance rate do identical twins have when it comes to depressive disorder?
40-50%
what’s the probability of first degree relatives of depressed individuals developing depression
3x more likely
can adopted children develop mood disorders simply because their biological parents had mood disorders
yes
what are the monoamine neurotransmitters
- serotonin
- norepinephrine
- dopamine
what monoamine neurotransmitter controls food intake
serotonin
what monoamine neurotransmitter controls sleep
serotonin
what neurotransmitter regulates emotions
serotonin
what neurotransmitter controls motivation
dopamine
what neurotransmitter controls cognition
dopamine
what neurotransmitter regulates emotional responses
dopamine
what neurotransmitter causes changes in attention
norepinephrine
what neurotransmitter causes changes in learning and memory
norepinephrine
what neurotransmitter causes changes in mood
norepinephrine
what neurotransmitter controls motivation, cognition; regulates emotional responses
dopamine
what neurotransmitter causes changes in attention, learning and memory, sleep and wakefulness, mood
norepinephrine
what are causes of dysregulation of neurotransmitters
- too few are released
- linger too briefly in synapses
- releasing presynaptic neurons reabsorb them too quickly
- conditions in the synapses do not support linkage with post synaptic receptors (monoamine oxidation)
- number of postsynaptic receptors have decreased
what medications cause depression
CNS depressants
antihypertensives
ant-acne
what CNS disorders cause depression
- cerebrovascular disorders
- temporal lobe tumors
- alzheimer’s disease
- huntington’s disease
- multiple sclerosis
what hormonal imbalances cause depression
adrenal dysfunction
- addison’s and cushing’s
estrogen - progesterone imbalance
what nutritional deficiencies cause depression
vitamin B complex deficiency
vitamin C deficiency
what are the b vitamins
b1 (thiamine)
b6 (pyridoxine)
b12 (cyanocobalamin)
what are CNS depressants
anxiolytics
antipsychotics
sedative-hypnotics
what is an example of antihypertensive that cause depression
propanolol
what anti-acne causes depression
isotretinoin
what feeling causes ambivalence
melancholia
what causes the formation of a weak ego and a punitive superego
melancholia
who created the concept of melancholia
sigmund freud
this imposes feeling of lack of control over life situation
learned helplessness
who created the idea of learned helplessness
seligman
this theory proposes that melancholia results to the formation of a weak ego and punitive superego, thus the development of depression
psychoanalytical theory by sigmund freud
this theory proposes that depressive illness is a result of having been abandoned by or otherwise separated from a significant other during the first 6 months of life
object loss theory
this theory proposes that the underlying cause of depressive affect is seen as cognitive distortions that result in negative, defeated attitudes
cognitive theory
what are the screening tests for depression
DASS - 21 (Depression, Anxiety and Stress Scale)
Hamilton Depression Rating Scale
this assesses for depression symptoms which will be used to determine severity of disease
hamilton depression rating scale
this is administered by a clinician
hamilton depression rating scale
this is a self-rating tool
DASS - 21
what are mHGAP protocol for management of depression
- provide psychoeducation to the person and their carer
- reduce stress and strengthen social supports
- promote functioning in daily activities and community life
- consider antidepressants
- if available, consider referral for brief psychosocial treatments
- do not manage the symptoms with ineffective treatments (i.e., vitamin injections)
t/f:
provide psychoeducation to the person only
false
provide psychoeducation to the person and their carer
t/f:
reduce stress and strengthen social supports
true
t/f:
promote functioning in daily activities and community life
true
t/f:
consider antipsychotics
false
consider antidepressants
t/f:
give vitamin injections as supportive care
false
do not manage symptoms with ineffective treatments
t/f:
if available, consider referral for brief psychosocial treatments
true
t/f:
depression is a rare condition
false
depression is a very common condition that can happen to anybody
t/f:
fatigue and avolition in a depressed person could be because they are just being weak and lazy
false
the occurrence of depression does not mean that the person is weak or lazy
t/f:
you should tell a depressed person to be more cheerful to keep the sadness away
false
depression cannot be controlled by sheer willpower
t/f:
the negative attitude of others may be due to the intangible nature of depression
true
t/f:
people with depression would have negative but real opinions about themselves, their life and their future
false
people with depression tend to have unrealistic negative opinions about themselves, their life and their future
t/f:
thoughts of self-harm or suicide are not that common but if they notice these thoughts, they should NOT act on them but instead tell a trusted person and seek help immediately
false
thoughts of self-harm and suicide are common
what are the action-oriented stress reduction strategies
- practicing assertiveness
- time management
- delegating
- managing expectations, commitments, and setting boundaries
- flexible or relaxed standards
- changing habits
what are the emotion-oriented stress reduction strategies
- positive self talk
- cognitive behavioral therapy
what are the acceptance-oriented stress reduction strategies
- diet and exercise
- meditation and physical relaxation
- avoiding social media sites which may exacerbate negative feelings
this stress reduction strategy confronts the problem causing stress
action-oriented
this stress reduction strategy changes our perspective about a stressful event; changes our response to stress
emotion-oriented
this stress reduction strategy acknowledges that stress co-exists with us and focus on how we can feel better as individuals
acceptance-oriented
t/f
starting previous social activities that the patient participated in before might trigger them to further sink into depression
false
starting social activities may potentially provide direct or indirect psychosocial support
t/f:
you should advise the patient to let their changes in appetite dictate their eating habits
false
- patients should try to eat regularly despite changes in appetite
t/f:
decision to start antidepressants shall be made both by the psychiatrist and the person
true
t/f:
antidepressants could be addictive
false
antidepressants are not addictive
t/f:
antidepressant medication is only taken during depressive episodes
false
regular intake of medication is important
t/f:
side effects should be immediately reported to the physician
false
some side effects may be experienced within the first few days but they usually resolve
t/f:
it may take several weeks before improvements in mood, interest or energy is noticed
true
medication usually needs to be continued for at least how many moths after resolution of symptoms
9-12 months
what is the time that it takes for the antidepressant to work
lag period
why do u have too continue antidepressant medication 9-12 months after the resolution?
to prevent relapse
what drugs are used for antidepressant therapy
SSRIs
TCAs
MAOIs
what is the mechanism of action of selective serotonin reuptake inhibitor
it blocks the reuptake of serotonin
why are selective serotonin reuptake inhibitors the first line of antidepressants
lower sedating, anticholinergic and cardiovascular side effects
what is the timeline of psychopharmacologic effect of antidepressant
reduced insomnia = 3-4 days
appetite normalize = 5-7 days
energy returns = 4-7 days
mood improves = 7-10 days
what SSRI is recommended for depression
fluoxetin (prozac)
what program recommends fluoxetine (prozac) as first line drug
MHGAP
what are side effects of SSRIs
- sedation
- insomnia
- headache
- dizziness
- GI disturbances
- changes in appetite
- sexual dysfunction
when do u give SSRIs at AM
when patient develops insomnia
why do u give SSRIs at pm
because of its sedative effect
what are the nursing interventions for people taking SSRIs
give in am if there is insomnia and pm if patient feels sedation
encourage drink adequate fluid report sexual difficulties
what are the most common ssris in the philippines
escitalopram
what are the side effects of escitalopram
- drowsiness
dizziness
wight gain
sexual dysfunction
restlessness
dry mouth
headache nausea
orthostatic hypotention
diarrhea
what are nursing responsibilities for escitalopram
check for orthostatic bp
assist client to rise slowly from sitting position
encourage use of sugar free beverages /hard candy
administer with food
this occurs when there is inadequate washout period between taking MAOIs & SSRIs/ when MAOIs are combined with meperidine
serotonin syndrome
what is a symptom of serotonin syndrome
changes in mental state
this primarily blocks reuptake of norepinephrine and to some degree serotonin too
tricyclic antidepressants
what is an example of tricyclic antidepressant
amitriptyline (elavil)
what are the side effects of amitriptyline (elavil)
- sedation
- orthostatic hypotension
- blurred vision
- dry mouth and sore throat
- difficulty urinating
- nausea
- weight gain
- sexual dysfunction
when do u administer amitriptyline (elavil)
hours of sleep
what drug interferes with enzyme metabolism (monoamine oxidase)
Monoamine oxidase inhibitor
how many weeks are the lag period of MAOIs
2-14 weeks
how many weeks is the washout period of MAOIs
5-6 weeks
what are the three monoamine oxidase inhibitors
tranylcypromine
phenelzine
isocarboxazid
what ar ethe brand names of the three monoamine oxidase inhibitors
parnate
nardil
marplan
what are the side effects of monoamine oxidase inhibitors
- drowsiness
- dry mouth
- overactivity
- insomnia
- nausea
- anorexia
- constipation
- orthostatic hypotension
what are the nursing interventions for MAOIs
- assist the client to rise from sitting
- administer at AM
- administer with food
- ensure adequate liquids
- educate importance of adhering to low tyramine diet
what is the adverse reaction caused by MAOIs
hypertensive crisis (cheese reaction)
this is a life threatening condition that can result when a client taking MAOIs ingests tyramine-containing foods
hypertensive crisi
this is a trace monoamine
tyramine
what are the clinical manifestations of hypertensive crisis
severe hypertension (BP> 180 mmHg systolic)
hyperpyrexia
tachycardia
diaphoresis
tremors
cardia dysrhythmias
when is the onset of hypertensive crisis
20-60 minutes after ingestion of tyramine containing foods
what is the drug of choice for hypertensive crisis caused by tyramine and MAOI ingestion
phentolamine
what drug class is phentolamine
adrenergic blocker
how do you prevent hypertensive crisis
adhere to low tyramine diet
what is a low tyramine diet
no processed foods
no canned goods
no aged cheese
this involves delivery of an electrical impulse to the brain to cause a seizure
electro convulsant therapy
what are the indications for ect
- unresponsive to antidepression
- patients who experience intolerable side effects at therapeutic levels
- pregnant women
- actively suicidal patients
what are the ect pre-procedure care
- facilitate signing of Informed consent
- NPO post midnight
- remove nail polish
- instruct to void before procedure
- start IV line
what are the ect preprocedure meds:
- atropine
- metohexital (brevital) IV
- succinylcholine (anectine) IV
what is atropine used for in ect
anticholinergic to reduce secretions
what is metohexital (brevital) IV used for in ect
for immediate anesthesia
what is succinylcholine (anectine) IV used for in ect
for neuromuscular blocking effect
why are muscle relaxants taken during ect
to prevent fractures caused by seizures
what are the criteria of a good, induced seizure in ECT
- monitor convulsions for at least 20 seconds
- increased HR for 30-50 seconds
- brain seizure as monitored by eeg for 30-50 secs
what are the side effects of ect
mild confusion/brief disorientation
fatigue
headache
short term memory loss
what are the post care for ect
- mechanically ventilate with 100% oxygen until patient can become unassisted
- monitor for respiratory problems
- reorient patient
- administer benzodiazepine IV when patient is agitated
this focuses on how a person thinks about self, others and future and interprets their experiences
cognitive therapy
this is the tendency to view everything in polar categories
absolute, dichotomous thinking
this is when the patient arrives at specific conclusion without sufficient evidence
arbitrary inference
this is when the patient focuses on a single detail while ignoring other bigger details
specific abstraction
this comes coming to a conclusion despite too little experience
overgeneralization
overestimating or underestimating the significance of something
magnification and minimalization
self references blame for external factors
personalization
what are the signs of manic bipolar disorder
- brightly colored clothing
- flamboyant
- sexually suggestive
- attention getting
- pressured speech: unrelentingly rapid
these are extreme mood swings from episodes of mania to episodes of depression
bipolar disorders
what are the phases of bipolar disorder
mania/hypomania
depression
euthymia
this is the bipolar disorder state of being in a natural mood
euthymia
this is characterized by hyper, expressive, irritable mood
mania
how many weeks does mania episode persists
1 week
what are the signs and symptoms of bipolar disorder manic phase
hyperactivity
elevated mood
distractibility
insomnia, irritability, increased interest in sex
grandiosity
flight of ideas
anger, anorexia
speech is loud and rapid; suicidal
talkative
this is the abnormal period where there is persistent elevated, expressive, irritable mood
hypomania
how many days is hypomania present
4 days
what are the signs and symptoms of hypomania
grandiosity
decreased need for sleep
subjective sense that thoughts are racing
distractibility
increase in goal-directed activity
excessive involvement in high risk fun activities
what are the types of bipolar disorder
bipolar type I
bipolar type II
cyclothymia
the patient experienced mood swings between manic and major depression
bipolar type 1
swings between major depression and hypomania
bipolar type II
patient experiences mood swings between hypomania and dysthymia but never at the extreme of the spectrum
cyclothymia
what is the criteria for cyclothymia
2 years no remission for 2 weeks
what is the probability of developing bipolar disorder in first degree relatives
2x
what is the probability of developing bipolar for patient offspring
50% chance
how much probability do identical twins have to develop bipolar
33% to 90%
what is a biochemical cause of bipolar disorder
catecholamine or increase in epinephrine and norepinephrine
what is the criteria of bipolar
at least 1 episode of mania
this etiology means that mania serves ad defense against the feelings of depression
psychodynamic
what is the defense mechanism of bipolar disorder
reaction formation
what are the environmental etiology for bipolar
external stressors
nature of work
increased exposure to sunlight