Mood & Anxiety Disorders

Question 1

Monoamine Oxidase Inhibitors (MAOIs) Contraindications

Answer 1

• Phenelzine
• Isocarboxazid
• Avoid tyramine-rich foods bc MAOIs prevent tyramines from being broken down ⇒ HTN crisis risk ⇒ monitor BP !!!
• Don’t use w/ other meds that ↑ serotonin lvls bc you’ll have higher risk for serotonin syndrome: excessive serotonin lvls ⇒ causing HYPOthermia, muscle rigidity, etc.
• Monitor for suicidal thoughts and behaviors
• Monitor LFTs bc they impact liver
• Don’t abruptly stop

Question 2

Tricyclic Antidepressants (TCAs) Side-Effects

Answer 2

• – triptyline
• – ipramine
• QT-prolongation ⇒ cardiac dysrhythmia
• Anticholinergic effects: “I’m dry and blind”
  
  • Blurred vision
  • Dry mouth
  • Dry eyes
  • Constipation
  • Urinary retention
• Orthostatic hypotension, dizziness from ↓ BP ⇒ fall risk and impaired coordination
• Sedation
• Suicidal ideation