Monoclonals/Protein Kinase Inhibitors

Question 1

Small molecule inhibitors of EGFR signaling

Answer 1

Erlotinib
Gefitinib
Afatinib
Osimertinib

Question 2

Small molecule inhibitors of EGFR signaling ADEs

Answer 2

diarrhea

acneform rash

Question 3

Small molecule inhibitors of EGFR signaling Mechanisms of resistance

Answer 3

alter the binding site
amplification of downstream signaling
increased efflux of drug

Question 4

Antibody inhibitors of EGFR signaling [MOA]

Answer 4

Keep EGF from binding to EGFR and keep them from dimerizing

Question 5

Antibody inhibitors of EGFR signaling

Answer 5

need +EGFR (amplified) and wild-type RAS

Question 6

Antibody inhibitors of EGFR signaling [Drugs]

Answer 6

Cetuximab
Necitumumab
Panitumumab

Question 7

HER2 Inhibitors

Answer 7

Herceptin
Lapatinib
Neratinib

Question 8

HER2 inhibitors MOA

Answer 8

antibodies: inhibit dimerization

small kinases: inhibit phosphorylation