Monoamine Oxidase Inhibitors (MAOI’s)

Question 1

Name the MAOI’s

Answer 1

Phenelzine (available through SAS)
Tranylcypromine (Pramine)

Question 2

MAOI MOA

Answer 2

Irreversibly inhibit monoamine oxidases A and B, increasing the synaptic concentrations of adrenaline, noradrenaline, dopamine and serotonin

Question 3

MAOI Indications

Answer 3

Major depression (third line) - reserved for use by psychiastrists

Question 4

MAOI Adverse Effects

Answer 4

Orthostatic hypotension
Sleep disturbances (take before 3pm)
Headache
Drowsiness
Fatigue

Question 5

MAOI Counselling

Answer 5

Take last dose before 3pm to avoid insomnia

Avoid foods containing tyramine while taking and for 2 weeks after stopping the medicine

Reduce caffeine intake if feeling jittery

May cause drowsiness and increase the effects of alcohol

Get up gradually from sitting or lying

Do not stop taking abruptly, unless you experience heart palpitations, or severe headaches