Monoamine Oxidase Inhibitors

Question 1

Phenelzine: class, halflife, side effects, limitations

Answer 1

MAOI, 4-5h, orthostatic hypotension, somnolence, weight gain; All cheese; tyramine-free diet: all cheese, fermented or aged foods, wine, and liver should be avoided; Should not be coadministered with SSRIs; Should never be coadministered with drugs that increase intrasynaptic levels of amine neurotransmitters

Question 2

Tranylcypromine: class, halflife, side effects, limitations

Answer 2

MAOI, 2-3h, orthostatic hypotension, somnolence, weight gain; All cheese; tyramine-free diet: all cheese, fermented or aged foods, wine, and liver should be avoided; Should not be coadministered with SSRIs; Should never be coadministered with drugs that increase intrasynaptic levels of amine neurotransmitters