Monitoring Drug Therapy Flashcards
Steven-Johnson syndrome and Toxic Epidermal Necrolysis can be caused by?
Seizure meds Allupurinol Sulfonamides Nevirapine Oxicams
What is therapeutic drug monitoring?
Phenytoin Carbamazepine Gentamicin Vancomycin Teicoplanin Lithium Digoxin Aminophylline / Theophylline
Amiodarone is associated with which three side effects? Therefore what must be monitored and how frequently?
Drug induced hyper and hypothyroidism
Measure TFTs every six months
Also pulmonary toxicity
Name a drug that can induced HTN
COCP
What should be monitored when a patient is on digoxin?
Plasma concentration
What increases the risk of digoxin toxicity?
Hyponatremia
Serum lithium concentration should be taken how many hours after dose?
12 hrs post dose
dose should be taken at night
Long term trimethoprim can cause
Bleeding disorders, so advise pt to look out for sore throat
Which tablets shouldn’t be crushed?
Modified-release (MR) tablets or capsules, or any medicine that may cause irritation to the stomach lining if the outer coating is broken
Bisphoshonates
Name some parenteral routes
IM
IV
Intrathecal
SC
Which excipient should be avoided in patients with Phenylketonuria
Aspartame
MR and EC drugs shouldn’t be given to which patients?
Those with ileostomy/bowel resection
What formulations can modified release drugs take?
Suspensions of drug (e.g. steroids for intra-articular use).
Drug dissolved in an oily base (e.g. depot antipsychotics).
Solid drug (e.g. hormonal implants).
Topical skin patches are designed to release the drug over several days (e.g. fentanyl patches).
Slow release eye drops which use a gel formulation (e.g. Timoptol® LA).
Meds prescribed by brand name include
Diltiazem preparations Some antiepileptics Lithium salts Theophylline preparations Some immunosuppressant therapies (e.g. tacrolimus)
Ciprofloxacilin should not be taken with
Indigestion tablets
Milk
