monitor during sedation Flashcards
advantages of oral sedation
universal acceptability easy to administer low cost involved reduced adverse reactions decreased severity of adverse reactions no special equipment needed
disadvantages of oral sedation
1!! – reliance on patient compliance
prolonged latent period (first pass effect)
erratic absorption from the GIT
inability to titrate
inability to readily lighten or deepen the level of sedation
often prolonged duration of action
prescribe oonly
the dose for the patient to take prior to proceudre
bioavailability
most orally administered drugs have a latent period of approx. 30 minutes – at this time the blood (plasma) level of the drug in at the minium (therapeutic) level
factors acting to influence absorption of the drug from the GI tract
1. lipid solubility ph of gastric tissues mucosal surface area gastric emptying time dosage form of the drug drug inactivatin presence of food in the stomach bioavaliability hepatic first pass effect
anxiety implication
can delay gastric empting – by as much as 2x – which will DELAY THE ONSET of action of antianxiety drugs
administer in oil or aqueous solution
more readily absorbed if given with aqueous solution over oily or capsule form
primary use of oral / rational
managment of anxiety before the dental procedure
strongly suggested that only minimal to moderate sedation be sought via oral route
contrainidaction for oral sedative
dentist must be cpaable of prompt recognition and managment of any adverse reaction that might develop
titration by appointment means
dentist will assess the efficacy of sedation achieved t the first appointment with a given dosage and if necessary, increase or decrease the dosage of drugs administered at subsequent appointments
- over a period of 2-3 appointments 0 the appropriate dosage for that patient can be achieved / titrated
antianiety drugs produce sedation?
no - but level of control over the anxiety of the patient
- antianxiety drugs
- edative -hypnotics
- benxo’s
- nonbenzo’s - histamine blockes
- opiod analgesics
benzo important fact
effective dose and lethal dose is a smaller margin than compared to benzo
LOWER MARGIN OF SAFETY
lower doses of these drugs produce
calming effect (sedation) usually associated with a degree of drwosniness and motor incoordination (ataxia) whereas higher dosages produce hypnosis – state resembling physiologic sleep
examples of benzos used
fluraxepam temazepam triazolam lorazepam midazolam
non benzos are
zoldiem
zaleplon
eszopiclone
chloral derivatives
- chloral hydrate
most popular and common class and effective drug for managemnt of dental fear and anxiety
benzo’s antianxiety agents
benzos act where
subcortical levels of the CNS – actions on limbic system + thalamus
doses smaller than those depressing the reicular activating system - and the cerebral cortex –
- barbs and other s do NOT exhibit selective depression, producing a more generalized CNS depression
benzo in dentistry for
MINIMAL TO MODERATE SEDATINO – DRUG OF CHOICE VIA THE ORAL ROUTE
give ___ the night before
flurazepam and triazolam
give ___ pre treatmetn
oxazepam (acitve metaboite or valium / diazepam) and diazepam
valium aka
diazepam
high safety index
anticonvulsant
skeletal muscle relaant
respiratory nd cardiac depression
has an active metabolite – oxazepam
peak 1 hour
dose 5-10 mg 1 hour before tx
contraindications to valium / diazepam
allergy, psychoses, acute narrow angle glaucoma, pregnancy age under 6
versed aka
midazolam
more potent than valium . diazepam
oral dose = ,5 mg / kg
expensive
water soluble
triazolam aka
halicion
no active metabolites
dose is .125 - 5 mg (.25mg)
anxiolysis
sleep
rapid onset - peak 1 hr
antergrade amnesia
alprazolam aka
xanax
dosage .25 - 1.0 mg
onset 1 hour
duration 1-2 hours
contraindications
- allergy
acute angle glaucoma
glaucoma