Molecular targets

Question 1

Which tumour cell is far from the blood vessels hence lacks energy source

Answer 1

Oxidative tumour cells

Question 2

Which tumour cell is close from the blood vessels hence has an energy source

Answer 2

Glycolytic tumour cell

Question 3

How does lactate pass from cell into tumour?

Answer 3

Using MCT1

Question 4

Describe THREE key metabolic changes in cancer cells

Answer 4

• Production of NADPH
• Faster ATP production
• Increased lactate production
• Increased production of glycolytic intermediates
• Higher expression of GLUT transporters on
  membranes

Question 5

Which transription factor plays a key role in cancer metoabolic reprogramming?

Answer 5

HIF-1 alpha

Question 6

Which metabolic process has drug available for therapy already?

Answer 6

Asparagine metbaolism

Question 7

Problems with mAb in cancer?

Answer 7

• Poor penetration into tumour mass

- Ineffecicient killing of cancer cell

Question 8

Solutions to mAb in cancer

Answer 8

1. Link Ab to a toxin
2. Coupling mAb to radiation or to a drug
3. Use of small Ab fragments - penetrate better into mass

Question 9

What is the role of HIF-1 alpha?

Answer 9

Driving glycolysis

Question 10

What is HIF-1 alpha driven by?

Answer 10

Hypoxia

High level of Oncogenes (PI3K, Ras)

Low level of oncosuppressors (p53)

Question 11

Vaccination for prostate canceR?

Answer 11

PROSTVAC-VF and/or Sipuleucel T