Molecular biology of the cell nucleus acronyms

Question 1

SMCs

Answer 1

structural maintenance of chromosomes

- Class of proteins involved in chromatin condensation e.g condensins

Question 2

CAPs

Answer 2

kleisin proteins

- form complex with SMCs to clamp chromatin fibres

Question 3

MAR or SAR

Answer 3

matrix- or scaffold-associated regions

- DNA is attached to these regions

Question 4

SAF-A

Answer 4

scaffold-attachment factor A

- Can directly bind to SAR elements

Question 5

RNP

Answer 5

ribonucleoprotein

- complex of ribonucleic acid and RNA-binding protein

Question 6

HP1

Answer 6

Heterochromatin protein 1

Question 7

H3K9

Answer 7

histone acetylation -> activating modification

Question 8

H3K9me

Answer 8

histone h3 that is methylated at lysine residue 9 > silencing

Question 9

Hi-C

Answer 9

High-resolution Chromosome conformation
capture
- techniques that enables the mapping of 3D DNA-DNA interactions

Question 10

ARS element

Answer 10

autonomously replicating sequence

- specific DNA fragment required for DNA replication in yeast

Question 11

ORC

Answer 11

Origin recognition complex

Question 12

MCM

Answer 12

minichromosome maintenance proteins

- DNA helicase essential for genomic DNA replication

Question 13

CEN

Answer 13

centromere

sequence

Question 14

TEL

Answer 14

Telomere

Question 15

YAC

Answer 15

yeast artificial chromosomes