Molecular Basis of Inheritance

Question 1

DNA as an acidic substance in nucleus was first discovered by

Answer 1

Friedrich Meischer

Question 2

Double helix model for the structure of DNA was proposed by

Answer 2

James Watson and Francis Crick

Question 3

X-ray diffraction data for structure of DNA was produced by

Answer 3

Maurice Wilkins and Rosalind Franklin

Question 4

The Central Dogma in molecular biology was proposed by

Answer 4

Francis Crick

Question 5

Transforming principle
Series of experiments with Streptococcus Pneumoniae was done by

Answer 5

Frederick Griffith

Question 6

Work on biochemical characterisation of transforming principle was done by

Answer 6

Oswald Avery, Colin MacLeod and Maclyn McCarty

Question 7

Unequivocal proof that DNA is the genetic material came from experiments with bacteriophage and E. coli done by

Answer 7

Alfred Hershey and Martha Chase

Question 8

Proof that DNA replicates semiconservatively was shown first in Escherichia coli by

Answer 8

Matthew Meselson and Franklin Stahl

Question 9

That the gentic code should be made up of three nucleotides was proposed by the physicist

Answer 9

George Gamow

Question 10

The chemical method for synthesising RNA molecules with defined combination of bases (homopolymers and copolymers) was developed by

Answer 10

Har Gobind Khorana

Question 11

Cell-free system for protein synthesis was developed by

Answer 11

Marshall Nirenberg

Question 12

The enzyme polynucleotide phosphorylase for polymerising RNA with defuned sequneces in a template independent manner was developed by

Answer 12

Severo Ochoa

Question 13

The lac operon was the first transcriptionally regulated system elucidated by

Answer 13

A genetics, Francois Jacob and a biochemist, Jacque Monod

Question 14

Automated DNA sequencers worked on the principle of a method developed by

Answer 14

Frederick Sanger

Question 15

The technique of DNA fingerprinting was initially developed by

Answer 15

Alec Jeffreys