Molecular Basis of Cancer

Question 1

What is cell division and proliferation regulated by?

Answer 1

Protonocogenes and tumour suppressor genes.

Question 2

What do protonocogenes do?

Answer 2

Growth promoting genes

Question 3

What do TSG do?

Answer 3

Negative regulators of the cell cycle

Question 4

What is Phosphorylation?

Answer 4

A protein passing a phosphate group to another protein.

Question 5

What is the purpose of phosphorylation

Answer 5

It helps pass signals through a chain of proteins

Question 6

What do Prot-oncogens code for to regulate growth/

Answer 6

onco-proteins

Question 7

Name the 6 types of oncogenes?

Answer 7

Nuclear binding protein
Tyrosine kinase protein
Growth factors
Receptors for growth factors
GTP binding protein

Question 8

Name 2 TSG genes

Answer 8

Rb1 and p53

Question 9

where is apc located and what does it supress

Answer 9

c5q, colerectal tumours

Question 10

what does nf1 supress and where is it

Answer 10

neurogibtosacrocoma 17q

Question 11

where is brac1 and what does it supress

Answer 11

17q and breast and overian caners

Question 12

where is p53 and what does it supress

Answer 12

lots of tumors

Question 13

where is rb1 and what does it supress

Answer 13

13q and retinoblastoma.

Question 14

Name two types of tumour supressor genes

Answer 14

gatekeeper and caretaker

Question 15

what does p53 do and what type is it

Answer 15

It is functional in the check points of the cell cycle at g,s,g2 , is a transcription factor , cell cycle arrest and dna repair and apoptosis

Question 16

how can tcg lose it functions

Answer 16

mutation and binding to proteins coded by viral genes.